Results 191 to 200 of about 753,077 (248)

Proteinase Inhibitors from Dog Submandibular Glands [PDF]

, 1971
Meister, Renate, Jaumann, Eugen, Fritz, Hans, Hochstrasser, Karl, Pasquay, Peter, Fink, Edwin   +5 more
core   +1 more source

Machine learning-driven docking of diverse DDAs as promising cysteine protease inhibitors targeting Mpox virus. [PDF]

In Silico Pharmacol
Alotaibi BS, Ahmad I, Almutairy B, Alkhammash A, Alsaiari AA, Khan K, Burki S.   +6 more
europepmc   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Multi-omics prediction of key proteases regulating scar formation and neural repair after spinal cord injury. [PDF]

Neural Regen Res
Jian H, Ren J, Du J, Wu K, Liu S, Zhao Y, Zhou H, Feng S.   +7 more
europepmc   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Cathepsin Z/X: Breaking Down the Known and Unknown. [PDF]

Int J Mol Sci
Zdravkova K, Pavicević M, Mijanović O, Branković A, Ilicheva PM, Stankovski A, Karanović J, Pualić D, Rubel AA, Rodionov IV, Savvateeva LV, Parodi A, Zamyatnin AA.   +12 more
europepmc   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Stefin B and Cystatin C Deficiency Suppresses Tumor Growth and Alters Tumor Microenvironment in a Breast Cancer Model. [PDF]

Cells
Matjan Štefin P, Završnik J, Butinar M, Mikhaylov G, Turk B, Vasiljeva O.   +5 more
europepmc   +1 more source

Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology

European Journal of Organic Chemistry, EarlyView.
Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau, Maxime Riberaud, Frédéric Taran, Antoine Sallustrau   +3 more
wiley   +1 more source

The Differential Redox Resilience of Alvelestat and Sivelestat: A Mechanistic Hypothesis for Inhibitor Performance Under Oxidative Stress. [PDF]

Molecules
D'Amato M, Linciano P, Chiarelli LR, Pietrocola G, Iadarola P, Collina S, Grignano MA, Gregorini M, Rampino T, Viglio S.   +9 more
europepmc   +1 more source