Results 61 to 70 of about 753,077 (248)

A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis

Arthritis Research & Therapy, 2023
Background Systemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis in the skin and internal organs, such as the lungs.
Hiroshi Kasamatsu, Takenao Chino, Takumi Hasegawa, Natsuko Utsunomiya, Akira Utsunomiya, Masami Yamada, Noritaka Oyama, Minoru Hasegawa   +7 more
doaj   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Digestive enzymes of vine weevil (Otiorhynchus sulcatus) as potential targets for insect control strategies. [PDF]

, 2002
Over the previous quarter century the vine weevil (Otiorhynchus sulcatus) has become a pest of horticultural and agricultural plants. The vine weevil is a polyphagous coleopteran insect and is able to attack over one hundred different plant species.
Edwards, M.G., Edwards, Martin Gethin
core  

Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe

, 2022
Covalent inhibitors of enzymes are increasingly appreciated as pharmaceutical seeds, yet discovering non-cysteine-targeting inhibitors remains challenging.
Naotaka Noda, Ken Tajiri, Lu Zhou, Naotaka Noda (6558761), Junichiro Takaya (1453048), Shin-ichi Sato, Junichiro Takaya, Masahiro Abo (716769), Motonari Uesugi (509631), Yejin Jung, Changyi Cui, Shin-ichi Sato (1452955), Masahiro Abo, Kohei Toh, Ken Tajiri (11998309), Yejin Jung (11998306), Lu Zhou (230418), Kohei Toh (9748288), Motonari Uesugi, Changyi Cui (287752)   +19 more
core   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Preliminary analysis of the proteolytic enzymes in the excretory-secretory products of the adult stages of the dog hookworm Uncinaria stenocephala

Parasite, 2001
The paper describes an introductory characterisation of proteinases present in the excretory-secretory products (ESP) of adult Uncinaria stenocephala.
Kotomski G., Wedrychowicz H.
doaj   +1 more source

Ethylene Signaling Mediates a Maize Defense Response to Insect Herbivory

Molecular Plant-Microbe Interactions, 2006
The signaling pathways that enable plants to mount defenses against insect herbivores are known to be complex. It was previously demonstrated that the insect-resistant maize (Zea mays L.) genotype Mp708 accumulates a unique defense cysteine proteinase ...
Antoine L. Harfouche, Renuka Shivaji, Russell Stocker, Paul W. Williams, Dawn S. Luthe   +4 more
doaj   +1 more source

Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability. [PDF]

PLoS Pathogens, 2016
Dengue is the most prevalent arboviral disease in humans and a major public health problem worldwide. Systemic plasma leakage, leading to hypovolemic shock and potentially fatal complications, is a critical determinant of dengue severity.
Henry Puerta-Guardo, Dustin R Glasner, Eva Harris   +2 more
doaj   +1 more source

Polyphenol‐Inspired Materials for Agricultural Applications

Advanced Materials, EarlyView.
This review outlines the use of polyphenol‐inspired materials for sustainable agriculture, highlighting their molecular design, interfacial assembly, structure–property relationships, and prospects toward precision agriculture, climate resilience, ecosystem protection, and circular bioeconomy strategies.
Haofu Liu, Omid Mazaheri, Zhixing Lin, Tianzheng Wang, Jingqu Chen, Yuang Gu, Xia Liang, Deli Chen, Frank Caruso   +8 more
wiley   +1 more source

Cystatin C: Its role in pathogenesis of OSMF

Journal of Oral Biology and Craniofacial Research, 2014
Oral Submucous Fibrosis (OSF) is a chronic disorder characterized by fibrosis of the mucosa lining the upper digestive tract involving the oral cavity, oro- and hypopharynx and the upper third of the oesophagus.
P.C. Anila Namboodiripad
doaj   +1 more source