Results 111 to 120 of about 27,857 (278)

Inducing disulfidptosis in tumors:potential pathways and significance

MedComm
Regulated cell death (RCD) is crucial for the elimination of abnormal cells. In recent years, strategies aimed at inducing RCD, particularly apoptosis, have become increasingly important in cancer therapy.
Tao Mi, Xiangpan Kong, Meiling Chen, Peng Guo, Dawei He   +4 more
doaj   +1 more source

Nanomaterials for enhanced X‐ray‐triggered cancer therapy: Progress and prospects

BMEMat, EarlyView.
This review summarizes the latest progress in nanomaterials for X‐ray‐triggered cancer therapy, highlighting their various advantages such as targeted delivery, reduced side effects, and enhanced therapeutic efficacy. Abstract X‐rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical ...
Yuanchun Chen, Shijie Shangguan, Zhongyu Lin, Xuemei Zeng, Siew Yin Chan, Xian Qin, Shuangqian Yan   +6 more
wiley   +1 more source

α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

Nature Network Boston, 2017
Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones.
Tiffany Zee, Neelanjan Bose, J. Zee, Jennifer N Beck, See Yang, J. Parihar, Min Yang, S. Damodar, David Hall, Monique N. O’Leary, A. Ramanathan, R. Gerona, D. Killilea, T. Chi, J. Tischfield, A. Sahota, A. Kahn, M. Stoller, P. Kapahi   +18 more
semanticscholar   +1 more source

Advances in the Release of Amide‐Containing Molecules

Chemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
The ability to release a molecule from a larger construct in a controlled manner is of great importance to produce effective prodrugs, antibody‐drug conjugates, and chemical probes. Amides are ubiquitous functional groups, yet methods to utilise them as molecular release handles are seldom reported.
Thomas Wharton, David R. Spring
wiley   +1 more source

Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia

Leukemia, 2022
Bryann Pardieu, Justine Pasanisi, Frank Ling, Reinaldo Dal Bello, Justine Penneroux, Angela H Su, Romane Joudinaud, Laureen Chat, Hsin-Chieh Wu, M. Duchmann, Gaetano Sodaro, Clémentine Chauvel, F. Castelli, Loic Vasseur, Kim Pacchiardi, Yannis Belloucif, Marie-Charlotte Laiguillon, Eshwar Meduri, Camille Vaganay, G. Alexe, J. Berrou, Chaima Benaksas, Antoine Forget, T. Braun, C. Gardin, E. Raffoux, E. Clappier, L. Adès, H. de Thé, F. Fenaille, B. Huntly, K. Stegmaier, H. Dombret, Nina Fenouille, Camille Lobry, A. Puissant, R. Itzykson   +36 more
semanticscholar   +1 more source

Plant cystine-knot peptides: pharmacological perspectives.

British Journal of Clinical Pharmacology, 2017
Cystine-knot miniproteins are a class of 30-50 amino acid long peptides widespread in eukaryotic organisms. Due to their very peculiar three-dimensional structure, they exhibit high resistance to heat and peptidase attack.
B. Molesini, D. Treggiari, A. Dalbeni, P. Minuz, T. Pandolfini   +4 more
semanticscholar   +1 more source

Size‐Dependent Ultrafast UV Photochemistry of Aliphatic Disulfides in Solution

Chemistry – A European Journal, EarlyView.
Aliphatic disulfides exclusively split homolytically along the S−S bond when directly exciting the disulfide chromophore at about 250 nm. Ultrafast (<1 ps) geminate recombination at high yield is observed in solution for fragment sizes as small as L‐cysteine. The smallest disulfide recombines ten‐fold more slowly.
Jessica Harich, Rory Ma, Miguel Ochmann, Antonia Freibert, Yujin Kim, Minseok Kim, Eunhyo Kim, Madhusudana Gopannagari, Junho Lee, Tae Gyun Woo, Haneol Oh, Ru‐Pan Wang, Jae Hyuk Lee, Tae Kyu Kim, Nils Huse   +14 more
wiley   +1 more source

Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas.

Cancer Research, 2016
Oncogenic transformation may reprogram tumor metabolism and render cancer cells addicted to extracellular nutrients. Deprivation of these nutrients may therefore represent a therapeutic opportunity, but predicting which nutrients cancer cells become ...
Xiaohu Tang, Jianli Wu, C. Ding, Min Lu, M. Keenan, Chao-Chieh Lin, Chih-An Lin, Charles C Wang, D. George, D. Hsu, J. Chi   +10 more
semanticscholar   +1 more source

Kinetically arrested SERS‐Active aggregates for biosensing

Chemistry – A European Journal, Accepted Article.
There is a demand for biosensors capable of long‐term, non‐invasive monitoring of low analyte concentrations in various biofluids for diagnostics, personalized healthcare, and disease monitoring. Biofluids present challenges to biosensor sensing and stability on account of their complex composition and dynamic nature.
Natalie S. Potter, Kamil Sokołowski, Renata Lang Sala, Jade A. McCune, Oren A. Scherman   +4 more
wiley   +1 more source

Tiny cystine stones in the gallbladder of a patient with cholecystolithiasis complicating acute cholecystitis: a case report

European Journal of Medical Research, 2012
Cystine stones, the main component of which is cystine, are very common urinary calculi, but are rare in the gall bladder. In animals, there has been only one report of cystine gallstones in tree shrews, and to our knowledge, this is the first report of ...
Qiao Tie, Ma Rui-hong, Luo Xiao-bing, Feng Yu-yang, Wang Xing-qiang, Zheng Pei-ming, Luo Zhen-liang   +6 more
doaj   +1 more source