Results 121 to 130 of about 49,829 (291)

Specific Cleavage of Cystine Peptides by Cyanide

open access: hybrid, 1966
Nicholas Catsimpoolas, John L. Wood
openalex   +1 more source

Fluorescence‐Guided Laser Lithotripsy: First Experience From a Clinical Study With Automatic Blocking of the Treatment Laser Beam

open access: yesTranslational Biophotonics, EarlyView.
The autofluorescence of urinary stones can be used for stone detection during laser lithotripsy. A system that automatically blocks the treatment laser in the event of incorrect fiber placement was tested in a clinical setting. ABSTRACT For several years, research has been conducted into fluorescence‐controlled laser lithotripsy, with the aim of ...
B. Lange   +5 more
wiley   +1 more source

Selection, counterselection, and conditional gene expression for genetic biocontrol of insects

open access: yesInsect Science, EarlyView.
Selection, counterselection, and conditional expression can be used for sex separation. Selection (S) and counterselection (CS) genes are linked to the sex chromosomes (e.g., the X and Y chromosomes) to confer sex‐specific selection or counterselection based on the presence or absence of the S or CS genes.
Melanie Hempel, Zhijian Tu
wiley   +1 more source

Early‐Life Climbing Stratifies the Metabolome and Mortality Risk in Genetically Identical Flies

open access: yesAging Cell, EarlyView.
Isogenic Drosophila melanogaster vary greatly in longevity. Fractionation of an isogenic cohort based on climbing behavior early in life stratifies variation in the metabolome, longevity and mortality risk offering a tractable system to study intrinsic sources of variation in aging.
Benjamin R. Harrison   +6 more
wiley   +1 more source

Drug Repurposing Screen Identifies Pimozide as a ROS‐Inducing Therapy With Anti‐Tumor Efficacy in HNSCC PDX Models

open access: yesCancer Science, EarlyView.
A drug repurposing screen for reactive oxygen species (ROS)‐inducing compounds identified Pimozide as a potent anti‐tumor agent in head and neck squamous cell carcinoma (HNSCC) patient‐derived xenograft (PDX) models. Combined treatment with paclitaxel markedly reduced undifferentiated tumor cells.
Shogo Okazaki   +12 more
wiley   +1 more source

Hippo Pathway Drives Durable Non‐Cell‐Autonomous Ferroptosis Resistance in Lung Cancer

open access: yesCancer Science, EarlyView.
YAP/TAZ, key effectors in lung cancer progression, paradoxically sensitize tumor cells to ferroptosis. This study reveals that YAP/TAZ‐low cells confer non‐cell‐autonomous, GCH1‐mediated durable ferroptosis resistance to neighboring YAP/TAZ‐high cells via a soluble factor, highlighting a Hippo pathway‐linked mechanism of tumor adaptation and survival ...
Mohamed Fathi Saleh   +6 more
wiley   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

open access: yesCell Proliferation, EarlyView.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao   +8 more
wiley   +1 more source

Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids.

open access: green, 1992
Joan Bertran   +9 more
openalex   +2 more sources

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