Results 121 to 130 of about 112,393 (379)

Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets

Nature Communications, 2017
Protein:protein interactions are among the most difficult to treat molecular mechanisms of disease pathology. Cystine-dense peptides have the potential to disrupt such interactions, and are used in drug-like roles by every clade of life, but their study ...
Zachary R. Crook, Gregory P. Sevilla, D. Friend, M. Brusniak, A. Bandaranayake, Midori Clarke, M. Gewe, A. Mhyre, D. Baker, R. Strong, P. Bradley, J. Olson   +11 more
semanticscholar   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, EarlyView.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review

Clinical Ophthalmology, 2018
Cystinosis is a rare, autosomal recessive disorder leading to defective transport of cystine out of lysosomes. Subsequent cystine crystal accumulation can occur in various tissues, including the ocular surface.
Achini Makuloluwa, F. Shams
semanticscholar   +1 more source

Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy

Annals of Neurology, EarlyView.
Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal, Sabine E. Olie, Michel van Weeghel, Bauke V. Schomakers, Frédéric M. Vaz, I‐PACE Study Group, Diederik van de Beek, Matthijs C. Brouwer   +7 more
wiley   +1 more source

Selective, Simple and Economical Method for the Voltammetric Determination of Bi(III) in the presence Cystine in Non – Complexing Solution

E3S Web of Conferences, 2013
The simple and fast method for the determination of Bi(III) in non-complexing solution was proposed. The catalytic activity of cystine on Bi(III) ions electroreduction process were utilized.
Nosal –Wiercińska A., Grochowski M., Tyszczuk–Rotko K., Skrzypek S., Guziejewski D.   +4 more
doaj   +1 more source

Cystine addiction of triple negative breast cancer associated with EMT augmented death signaling

Oncogene, 2016
Despite the advances in the diagnosis and treatment of breast cancer, breast cancers still cause significant mortality. For some patients, especially those with triple-negative breast cancer, current treatments continue to be limited and ineffective ...
Xiaohu Tang, C. Ding, Jianli Wu, J. Sjol, S. Wardell, D. George, D. McDonnell, D. Hsu, Jeffrey T. Chang, J. Chi   +9 more
semanticscholar   +1 more source

Approaches to Enhance Photodynamic Therapy of Lung Cancer: Potential Application of Nanoparticles

Advanced NanoBiomed Research, EarlyView.
Bioactive ligand‐targeted nanocarriers can accommodate functionalization with numerous targeting ligands for effective delivery of photosensitizers (PSs) within targeted photodynamic therapy. Various targeting moieties including peptides, antibodies, carbohydrates, aptamers, proteins, and PS anticancer molecules can be attached to nanomaterials.
Nokuphila Winifred Nompumelelo Simelane, Heidi Abrahamse   +1 more
wiley   +1 more source

\u3cem\u3eN\u3c/em\u3e-acetylcysteine Decreases Binge Eating in a Rodent Model [PDF]

, 2016
Binge-eating behavior involves rapid consumption of highly palatable foods leading to increased weight gain. Feeding in binge disorders resembles other compulsive behaviors, many of which are responsive to N-acetylcysteine (NAC), which is a cysteine ...
Baker, David A., Choi, Sujean, Frenkel, M. M., Hurley, M. M., Maunze, Brian, Resch, Jon M.   +5 more
core   +1 more source

Ungesättigte Phosphinoxide für modulares Antikörper‐Rebridging und Einkomponenten Peptid‐Zyklisierung‐Biokonjugation

Angewandte Chemie, EarlyView.
Wir berichten über die modulare Synthese ungesättigter PV‐Reagenzien ausgehend von Triethinyl‐Phosphinoxid mittels CuAAC. Diethinyl‐Triazolyl‐Phosphinoxide ermöglichen das schnelle, selektive und stabile Rebridging von Antikörper‐Disulfidbrücken, wie am Beispiel eines selektiv wirksamen Antikörper‐Wirkstoff‐Konjugats gezeigt wird.
Christian E. Stieger, Alastair J. McMillan, Mark A. R. de Geus, Jan Vincent V. Arafiles, Luise Franz, Christian P. R. Hackenberger   +5 more
wiley   +1 more source

The effect of amino acid enantiomers on activity of selected enzymes in soil

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2011
This work was aimed to test the effect of selected amino acid enantiomers on activity of casein-protease and acid phosphomonoesterase in soil. Casein-protease was selected due to its key role in nitrogen mineralization and acid phosphomonoesterase due to
Peter Dundek, Ladislav Holík, Valerie Vranová, Klement Rejšek, Pavel Formánek   +4 more
doaj   +1 more source