Results 141 to 150 of about 95,243 (337)

Drug Repurposing Screen Identifies Pimozide as a ROS‐Inducing Therapy With Anti‐Tumor Efficacy in HNSCC PDX Models

Cancer Science, EarlyView.
A drug repurposing screen for reactive oxygen species (ROS)‐inducing compounds identified Pimozide as a potent anti‐tumor agent in head and neck squamous cell carcinoma (HNSCC) patient‐derived xenograft (PDX) models. Combined treatment with paclitaxel markedly reduced undifferentiated tumor cells.
Shogo Okazaki, Shintaro Nakamura, Tomoya Soma, Momoko Yoshikawa, Seiji Asoda, Yurika Nakajima, Kenji Tsuchihashi, Mitsuyo Ohmura, Ryo Goitsuka, Kenichi Imai, Hideyuki Saya, Osamu Nagano, Hiroyuki Ozawa   +12 more
wiley   +1 more source

The Progress of Ferroptosis of Immune Cells in the Tumor Microenvironment and Its Impact on Tumorigenesis and Development. [PDF]

Immun Inflamm Dis
The interplay between ferroptosis and the tumor immune microenvironment significantly influences the outcome of cancer immunotherapy. Inducing ferroptosis in tumor cells and immunosuppressive cells, while preventing ferroptosis in effector immune cells, emerges as a promising strategy to enhance the efficacy of immunotherapy. This review highlights the
Zhan F, Hu Y, Jiang X, Fang Z.
europepmc   +2 more sources

Specific Cleavage of Cystine Peptides by Cyanide

, 1966
Nicholas Catsimpoolas, John L. Wood
openalex   +1 more source

Hippo Pathway Drives Durable Non‐Cell‐Autonomous Ferroptosis Resistance in Lung Cancer

Cancer Science, EarlyView.
YAP/TAZ, key effectors in lung cancer progression, paradoxically sensitize tumor cells to ferroptosis. This study reveals that YAP/TAZ‐low cells confer non‐cell‐autonomous, GCH1‐mediated durable ferroptosis resistance to neighboring YAP/TAZ‐high cells via a soluble factor, highlighting a Hippo pathway‐linked mechanism of tumor adaptation and survival ...
Mohamed Fathi Saleh, Akihiro Nita, Yudai Ohta, Aya Kobayashi, Hao Li, Yasuhisa Sakamoto, Toshiro Moroishi   +6 more
wiley   +1 more source

An Open-Label, Phase III Study to Assess the Efficacy and Safety of Cysteamine Ophthalmic Solution 0.55% in Japanese Cystinosis Patients

Clinical Ophthalmology
Nobuhiro Goi,1 Fumino Iwata,2 Yoko Sugihara,3 Shingo Higa,1 Taiichiro Chikama4 1Medical Affairs, Viatris Pharmaceuticals Japan G.K., Tokyo, Japan; 2Iwata Eye Clinic, 2-15-21 Nishinakanobu, Shinagawa-ku, Tokyo, 142-0054, Japan; 3Global Clinical Operations,
Goi N, Iwata F, Sugihara Y, Higa S, Chikama T   +4 more
doaj  

THE DETERMINATION OF THIOL AND DISULFIDE COMPOUNDS, WITH SPECIAL REFERENCE TO CYSTEINE AND CYSTINE

, 1937
Kamenosuke Shinohara
openalex   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, EarlyView.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

LCN2‐ACOD1 Signalling Affects the Post‐Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis

Cell Proliferation, EarlyView.
LCN2 mediates the suppression of C2C12 myoblast proliferation and myotube formation via erastin‐induced ferroptosis. Mechanistically, the LCN2‐ACOD1 axis regulates skeletal muscle growth via mitochondria‐associated ferroptosis, providing a theoretical basis for the prevention and therapy of muscle‐related diseases.
Xiaojing Hao, Hongwei Shi, Di Wu, Rui Liang, Tong Zhao, Wen Sun, Yue Wang, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Haidong Wang, Juan Wang   +12 more
wiley   +1 more source

THE INFLUENCE OF SUPPLEMENTARY CASEIN, CYSTINE, AND METHIONINE ON LIVER LIPID CONTENT

, 1942
C. R. Treadwell, Marjorie Janice Groothuis, H.C. Eckstein   +2 more
openalex   +1 more source

Intracellular Cystine Loading Causes Proximal Tubule Respiratory Dysfunction: Effect of Glycine [PDF]

, 1992
Abdullah Şakarcan, Rebecca Aricheta, Michel Baum   +2 more
openalex   +1 more source