Results 161 to 170 of about 47,323 (291)

Salvianolic Acid B Attenuates Ferroptosis in Acute Kidney Injury by Targeting PRDX5

open access: yesThe FASEB Journal, Volume 39, Issue 14, 31 July 2025.
Mechanistic diagram of SAB‐mediated alleviation of AKI through the regulation of PRDX5‐mediated ferroptosis in renal tubular epithelial cells. SAB alleviates cisplatin‐ and FA‐induced AKI by inhibiting ferroptosis via PRDX5‐mediated upregulation of SLC7A11, GPX4, and FSP1.
Yan Tao   +5 more
wiley   +1 more source

RasGRP4 Exacerbates Diabetic Kidney Fibrosis via Aloxe3‐Mediated Oxidative Stress and Scar‐Associated Macrophage Activation

open access: yesThe FASEB Journal, Volume 39, Issue 14, 31 July 2025.
In the article “RasGRP4 Exacerbates Diabetic Kidney Fibrosis via Aloxe3‐Mediated Oxidative Stress and Scar‐Associated Macrophage Activation”, Peiyu et al. describe RasGRP4 in macrophages exacerbates diabetic kidney fibrosis by inducing Aloxe3‐mediated oxidative stress to activate scar‐associated macrophages (SAM).
Binshan Zhang   +10 more
wiley   +1 more source

Homocysteine: Canary in the Coal Mine or Hidden Threat? A Biochemical Study on the Role of Plasma Thiols

open access: yesThe FASEB Journal, Volume 39, Issue 13, 15 July 2025.
The figure illustrates how high plasma glutathione levels can promote the dethiolation of homocysteinylated proteins, leading to the release of homocysteine. The freed homocysteine is then either excreted through the kidneys or further processed via cellular metabolism, supporting homocysteine clearance and metabolic balance.
Daniela Giustarini   +3 more
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

open access: yesAngewandte Chemie, Volume 137, Issue 27, July 1, 2025.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka   +5 more
wiley   +2 more sources

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