Results 201 to 210 of about 49,829 (291)

Tailoring PHA copolymer types via amino acid supplementation in dairy byproduct media. [PDF]

open access: yesSci Rep
Patil T   +7 more
europepmc   +1 more source

From Gene to Enzyme: Multidimensional Decoding of the GGT Molecular Family and Its Clinical Tumor Diagnosis

open access: yesCancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Gamma‐glutamyltransferase (GGT) is a membrane‐bound enzyme involved in glutathione metabolism and oxidative stress regulation. Although it is traditionally viewed as a liver function marker, emerging evidence suggests that its aberrant expression is closely associated with tumorigenesis, progression, and therapeutic resistance ...
Fei Wang   +11 more
wiley   +1 more source

Interaction between nuclear‐translocated cellular communication network factor 2 and purine‐rich box 1 regulates the expression of fibrosis‐related genes

open access: yesJournal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Although cellular communication network factor 2 (CCN2) is secreted out to the extracellular environment, intracellular CCN2 rather than re‐incorporated CCN2 from the outside may be involved in its translocation into the nuclei, because translocation of CCN2 into the nucleus was not disturbed by soluble heparin.
Xuan Thi Nguyen   +3 more
wiley   +1 more source

The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches

open access: yesESC Heart Failure, Volume 12, Issue 6, Page 4000-4020, December 2025.
Nrf2 signalling is impaired in heart failure, contributing to oxidative stress, mitochondrial dysfunction, and ferroptosis, which drive neurohormonal activation, inflammation, and ischaemia‐reperfusion injury. This loss of Nrf2 activity exacerbates hypertension, diabetic cardiomyopathy, and cardiotoxicity, accelerating progression to overt heart ...
Emiliano Fiori   +9 more
wiley   +1 more source

Metabolic Functions and Mechanisms of Selenium, Selenocysteine, and GPX4 Mediated Immune Regulation Through Autophagy in Solid Tumors

open access: yesFood Science &Nutrition, Volume 13, Issue 12, December 2025.
This paper focuses on selenium, selenocysteine, and GPX4, elaborating on their metabolic functions and mechanisms in mediating immune regulation through autophagy in solid tumors. It explores the characteristics of selenium metabolism in tumors and the roles of related enzymes, providing new directions for cancer treatment.
Liang Yang   +7 more
wiley   +1 more source

Hydrogen sulfide-dependent activation of human sulfide quinone oxidoreductase. [PDF]

open access: yesJ Biol Chem
Roman JV   +6 more
europepmc   +1 more source

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