Results 211 to 220 of about 27,857 (278)
Smart Medicine, Volume 4, Issue 2, June 2025.Molecular target engagements and metabolic changes reveal that NSC48160 inhibits the progression of HCC through ferroptosis. NSC48160 elucidates the ferroptosis mechanism whereby it impedes KRAS and instigates the downregulation of Nrf2/SLC7A11/GPX4.
Jiaxin Zhang +5 more
wiley +1 more source
The Effect of Cystine on the Endogenous Metabolism of Molting Hens [PDF]
, 1926 C. W. Ackerson, M. J. Blish
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GGCT Inhibits Ferroptosis in PTC Cells by Upregulating p53 Through RPS15A
Cancer Science, Volume 116, Issue 6, Page 1592-1603, June 2025.Our results showed that γ‐glutamine cyclotransferase (GGCT) knockdown in PTC cells inhibited GSH synthesis, promoted the malignant accumulation of malondialdehyde (MDA) and reactive oxygen species (ROS), and finally promoted cell ferroptosis. In vivo experiments showed that Pro‐GA, a specific inhibitor of GGCT, inhibited the subcutaneous tumorigenesis ...
Hui‐min Zhang +9 more
wiley +1 more source
THE UTILIZATION OF CYSTEINE AND CYSTINE BY RAT LIVER WITH THE PRODUCTION OF HYDROGEN SULFIDE
, 1942 C.V. Smythe
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VCP Promotes Cholangiocarcinoma Development by Mediating BAP1 Ubiquitination‐Dependent Degradation
Cancer Science, Volume 116, Issue 6, Page 1579-1591, June 2025.It demonstrates the tumor‐suppressive roles of BAP1 in CCA: BAP1 significantly inhibits CCA cell proliferation and tumor progression. It identifies VCP as a key upstream regulator mediating BAP1 homeostasis: VCP binds to BAP1 and promotes the latter's ubiquitination degradation via the ubiquitin‐proteasome pathway.
Peiying Zhang +10 more
wiley +1 more source
Neural Metabolic Networks: Key Elements of Healthy Brain Function
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.This review originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School (2022). Here, we describe how the specific bioenergetic profiles and metabolic exchanges between brain cells enable and gate synaptic function and behavior. Then, based on this analysis, we discuss the potential role
Nimrod Madrer +20 more
wiley +1 more source
CYSTINE REDUCTASE OF PEA SEEDS AND YEASTS
, 1954 Antonio H. Romano, Walter J. Nickerson
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