Results 211 to 220 of about 47,323 (291)
Molecular Alterations in Ferroptosis and the Effects of Resveratrol: A Systematic Review
Ferroptosis is a cell death mechanism characterized by iron overload, accumulation of reactive oxygen species, deficits in glutathione metabolism, lipid peroxidation, and mitochondrial impairments. Resveratrol can prevent or reverse these alterations by chelating iron and upregulating antioxidant defenses. ABSTRACT Ferroptosis is an iron‐dependent cell
Ana Beatriz Dos Santos+4 more
wiley +1 more source
Ferroptosis as a therapeutic vulnerability in MDM2 inhibition in dedifferentiated liposarcoma. [PDF]
Yen CC+11 more
europepmc +1 more source
THE COLORIMETRIC ESTIMATION OF CYSTINE AND GLUTATHIONE
George Hunter, Blythe Alfred Eagles
openalex +1 more source
Gene Dosage Sensitivity and Human Genetic Diseases
ABSTRACT Here we review the historical background and contemporary insights into genetic dominance, focusing on haploinsufficiency (HI), that is, when the function of only one allele of a gene is not enough to ensure a normal phenotype in a diploid organism.
Reiner A. Veitia+2 more
wiley +1 more source
Theranostic Contact Lens for Ocular Cystinosis Utilizing Gold Nanoparticles. [PDF]
Ha E, Kang H, Noh H.
europepmc +1 more source
THE CONVERSION OF S35-HOMOLANTHIONINE TO S35-CYSTINE IN THE RAT
Jakob A. Stekol, Kathryn. Weiss
openalex +1 more source
Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar+10 more
wiley +1 more source
Oxidative Stress: Signaling Pathways, Biological Functions, and Disease
Oxidative stress causes cellular damage across multiple systems, contributing to neurodegeneration (Alzheimer's, Parkinson's, Huntington's), cancer progression and resistance, cardiovascular diseases (atherosclerosis, heart failure), liver and kidney injury, metabolic disorders (diabetes, obesity), autoimmune diseases, musculoskeletal decline, retinal ...
Sixuan Liu+4 more
wiley +1 more source