Results 31 to 40 of about 112,393 (379)

Reduction in Phencyclidine Induced Sensorimotor Gating Deficits in the Rat Following Increased System Xc − Activity in the Medial Prefrontal Cortex [PDF]

, 2013
Rationale: Aspects of schizophrenia, including deficits in sensorimotor gating, have been linked to glutamate dysfunction and/or oxidative stress in the prefrontal cortex. System xc −, a cystine–glutamate antiporter, is a poorly understood mechanism that
A Araque, A Kulak, A Wilmsmeier, B Moghaddam, B Moghaddam, B Oranje, BJ Morris, D Braff, D Lobner, D Matsuzawa, D Piani, DA Baker, DA Baker, David A. Baker, DH Ingvar, DL Braff, DV Pow, FK Graham, G Battaglia, G Franzen, G Paxinos, G Paxinos, G Rajkowska, HH Chen, J Cilia, JA Lieberman, JH Cabungcal, JI Sagara, Jon Resch, JT Coyle, K Japha, K Moussawi, K Moussawi, K Ogita, K Schwabe, K Shimosato, KE Poskanzer, KF Berman, KQ Do, Krista Qualmann, KS Kau, L Deserno, L Pasti, LA Glantz, Linghai Kong, LJ Garey, M Berk, M Berk, M Koch, M Li, M Raffa, MA Geyer, MC Angulo, ME Jackson, MJ Marino, MM Moran, NA Oberheim, NM Veelen van, NR Swerdlow, NR Swerdlow, NR Swerdlow, NR Swerdlow, O Kranich, P Bezzi, P Steullet, R Bridges, R Gysin, R Janaky, S Bannai, S Bannai, S Bannai, SG Potkin, SuJean Choi, T Majic, V Kumari, V Parpura, Victoria Lutgen, VM Goghari, VP Bakshi, WE Bunney, Y Cho, ZC Ye   +81 more
core   +2 more sources

Cataracte d´arbre de Noël

PAMJ Clinical Medicine, 2020
Nous rapportons le cas d'un patient de 55 ans, sans antécédents pathologiques notables, qui consulte pour baisse d`acuité visuelle d'installation progressive.
Narjisse Taouri, Wafae Cherkaoui
doaj   +1 more source

Antioxidant and Anti-Urolithiatic Activity of Aqueous and Ethanolic Extracts from Saussurea costus (Falc) Lispich Using Scanning Electron Microscopy

Life, 2022
The plant Saussurea costus (Falc) Lipsch has many biological activities and a strong curative and preventive power against a variety of diseases including cancer, diabetes, and hemorrhoids. In the current study, phytochemical screening was carried out as
Naima Mammate, Fatima Ezzahra El oumari, Hamada Imtara, Salim Belchkar, Anissa Lahrichi, Ali S. Alqahtani, Omar M. Noman, Mahmoud Tarayrah, Tarik Sqalli Houssaini   +8 more
doaj   +1 more source

Influence of Sulfur-Containing Diamino Acid Structure on Covalently Crosslinked Copolypeptide Hydrogels. [PDF]

, 2018
Biologically occurring non-canonical di-α-amino acids were converted into new di-N-carboxyanhydride (di-NCA) monomers in reasonable yields with high purity.
Deming, Timothy J, Gharkhanian, Eric G, McNamara, J, Raftery, Eric D, Ricapito, Nicole G   +4 more
core   +1 more source

The content of non-essential amino acids in the grains of winter and spring varieties of oats (Avena sativa L.) under the conditions of Central Southern Bulgaria [PDF]

Agroznanje, 2013
The purpose of this survey is to study the content of non-essential amino acids in four winter (Dunav 1, Ruse 8, Resor 1, Line M-K) and five spring (Obraztsov chiflik 4, Mina, HiFi, Novosadski golozarnest and Prista 2) cultivars of oats grown in Central ...
Georgieva T., Zorovski P.
doaj   +1 more source

Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc− for Glutathione Synthesis in Lung Cancer

Cancer Research, 2020
Cellular GSH in cancer cells is not only determined by upregulated Xc− but also by dysregulated glutamate transporters, which provide additional targets for therapeutic intervention.
Wenzheng Guo, Kaimi Li, Beibei Sun, Dongliang Xu, Lingfeng Tong, Huijing Yin, Yueling Liao, Hongyong Song, Tong Wang, Bo Jing, Min Hu, Shuli Liu, Yanbin Kuang, Jing Ling, Qi Li, Yadi Wu, Qi Wang, F. Yao, Binhua P. Zhou, Shu-hai Lin, Jiong Deng   +20 more
semanticscholar   +1 more source

Cystine import is a valuable but risky process whose hazards Escherichia coli minimizes by inducing a cysteine exporter

Molecular Microbiology, 2020
The structure of free cysteine makes it vulnerable to oxidation by molecular oxygen; consequently, organisms that live in oxic habitats have acquired the ability to import cystine as a sulfur source.
S. Korshunov, K. Imlay, J. Imlay
semanticscholar   +1 more source

Quantitative determination of D4-cystine in mice using LC-MS/MS and its application to the assessment of pharmacokinetics and bioavailability

Journal of Pharmaceutical Analysis, 2021
Cystine is the primary source material for the synthesis of glutathione. However, the pharmacokinetics and tissue distribution of cystine are largely unknown.
Shuning Li, Zhenyao Lu, Li Jiao, Ran Zhang, Yu Hong, Jiye Aa, Guangji Wang   +6 more
doaj   +1 more source

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance RAS genes are among the most mutated proto-oncogenes in human cancer. The mechanisms supporting RAS transformation are not fully understood, particularly regarding the relative contributions of oxidant versus antioxidant pathways.
Jonathan K. M. Lim, A. Delaidelli, Sean W. Minaker, Hai-Feng Zhang, M. Čolović, Hua Yang, G. Negri, S. von Karstedt, W. Lockwood, P. Schaffer, G. Leprivier, P. Sorensen   +11 more
semanticscholar   +1 more source

Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [PDF]

, 2005
MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the ...
Avrutina, Olga, Diederichsen, Ulf, Gabrijelcic-Geiger, Dusica, Kolmar, Harald, Le Nguyen, Dung, Schmoldt, Hans-Ulrich, Sommerhoff, Christian P.   +6 more
core   +1 more source