The Type of Fat in the Diet Influences the Behavior and the Relationship Between Cystinyl and Alanyl Aminopeptidase Activities in Frontal Cortex, Liver, and Plasma [PDF]
Frontiers in Molecular Biosciences, 2020 Insulin-regulated aminopeptidase (IRAP, cystinyl aminopeptidase, CysAP) and aminopeptidase M (alanyl aminopeptidase, AlaAP) are closely related enzymes involved in cognitive, metabolic, and cardiovascular functions.
Ana BELÉN Segarra +2 more
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Leucyl and Cystinyl Aminopeptidase as a Prognostic-Related Biomarker in OV Correlating with Immune Infiltrates [PDF]
Pharmacogenomics and Personalized Medicine, 2023 Qian Ma,1,* Lei Chang,2,* Wenwen Wang,2,* Lingyi Che,1 Xiaoqin Song,3 Gailing Li,2 Ying Zhang,2 Yibing Chen,1 Zhuoyu Gu,4 Xin Ge5 1Genetics and Prenatal Diagnosis Center, First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052 ...
Ma Q +9 more
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Expression of Oxytocin/Neurophysin I and Oxytocinase in the Equine Conceptus from Day 8 to Day 21 Post-Ovulation [PDF]
Animals, 2022 Leucyl and cystinyl aminopeptidase (LNPEP/oxytocinase) is an enzyme that metabolizes oxytocin in serum and tissues. The presence of oxytocin/neurophysin I (OXT), oxytocin and LNPEP and their relationship to other genes is unknown in the equine conceptus.
Mariana Diel de Amorim +5 more
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Metal ion modulation of cystinyl aminopeptidase [PDF]
Biochemical Journal, 2005 Cystinyl aminopeptidase has one Zn2+-binding motif and is a member of the M1 aminopeptidase family. Ion modulation of its catalytic activity was studied in membranes of CHO-K1 cells (Chinese-hamster ovary K1 cells) using L-leucine-p-nitroanilide as substrate.
Heidi Demaegdt +2 more
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The Role of Aminopeptidase ERAP1 in Human Pathology—A Review [PDF]
Current Issues in Molecular BiologyAminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for endoplasmic
Laura Țiburcă +5 more
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Genome-wide mapping of the binding sites of myocyte enhancer factor 2A in chicken primary myoblasts [PDF]
Poultry Science: Myocyte enhancer factor 2A (MEF2A) is a transcription factor that plays a critical role in cell proliferation, differentiation and apoptosis. In contrast to the wide characterization of its regulation mechanism in mammalian skeletal muscle, its role in
Xinglong Wang +8 more
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Characterization of serum and tissue oxytocinase and tissue oxytocin in the pregnant and non-pregnant mare [PDF]
Scientific Reports, 2023 Oxytocin is a hormone with functions in: reproduction, maternal bonding, milk ejection, and feeding/social behavior, and is reported to be present in a variety of tissues. Our goal is to characterize oxytocin and leucyl and cystinyl aminopeptidase (LNPEP/
Mariana Diel de Amorim +7 more
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Development of an Assay to Distinguish Between Genotypes of the Leucyl-Cystinyl Aminopeptidase Gene
Re:GEN Open, 2022 Introduction: The leucyl-cystinyl aminopeptidase gene rs4869317 single nucleotide polymorphism (SNP) is associated with multiple conditions; for example, patients with the rs4869317 TT genotype experiencing septic shock have increased plasma clearance of vasopressin versus AA or AT genotypes.
Saji Vijayan
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Purification and characterization of the cystinyl bond cleaving yeast aminopeptidase yscXVI [PDF]
FEBS Letters, 1993 Aminopeptidase yscXVI was purified from the yeast Saccharomyces cerevisiae. By SDS‐PAGE the enzyme has a molecular weight of 45,000 Da, and in chromatofocusing, elution was observed at pH 6.2. The synthetic substrate cystinyl‐4‐nitroanilide (K m 22.5μM, V max 12.9 mU/mg) is cleaved most efficiently in the pH range 7–8.
U Tišljar, Dieter H Wolf
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Thyroid Disorders Change the Pattern of Response of Angiotensinase Activities in the Hypothalamus-Pituitary-Adrenal Axis of Male Rats [PDF]
Frontiers in Endocrinology, 2018 Thyroid disorders affect the hypothalamic-pituitary-adrenal axis with important consequences on the cardiovascular function in which the renin-angiotensin system plays a major role.
Ana B. Segarra +5 more
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