Results 11 to 20 of about 431 (97)

Early prognostic markers to predict unsuccessful pregnancy in dairy cattle

Reproduction in Domestic Animals, Volume 59, Issue 5, May 2024.
This study aimed to investigate maternal serum levels of some angiogenic factors and certain proteins in dairy cattle for (1) early prediction of unsuccessful fertilization and (2) early detection of possible pregnancy failures (early EM) after positive ...
Takci, Abdurrahman, Uysal, Ersin, Em, Bernan, Ercan, Nazli, Yokus, Beran   +4 more
core   +2 more sources

The Type of Fat in the Diet Influences Regulatory Aminopeptidases of the Renin-Angiotensin System and Stress in the Hypothalamic-Pituitary-Adrenal Axis in Adult Wistar Rats. [PDF]

Nutrients, 2021
(1) Background: Prolonged feeding with a high-fat diet (HFD) acts as a stressor by activating the functions of the hypothalamic-pituitary-adrenal gland (HPA) stress axis, accompanied of hypertension by inducing the renin-angiotensin-aldosterone system ...
Domínguez-Vías G, Segarra AB, Ramírez-Sánchez M, Prieto I.   +3 more
europepmc   +3 more sources

A Common Genetic Background for Psoriasis and Cardiovascular Diseases: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Psoriasis is an immune‐mediated disease affecting primarily the skin and joints, but which also has systemic implications. There are assumptions about a common genetic background between psoriasis and cardiovascular diseases.
Lazar AL, Romana Vulturar C, Sitar-Tăut AV, Suharoschi R, Orășan OH, Chiș AA, Fodor A, Tiperciuc B, Login C, Cozma A.   +9 more
europepmc   +2 more sources

Editorial: Physiological, Pathological Roles and Pharmacology of Insulin Regulated Aminopeptidase [PDF]

Frontiers in Molecular Biosciences, 2021
Siew Yeen Chai, Hugo Gutiérrez-De-Terán, Efstratios Stratikos   +2 more
exaly   +2 more sources

A Pregnant Woman with Excess Vasopressinase-Induced Diabetes Insipidus Complicated by Central Diabetes Insipidus like Lymphocytic Infundibulo-Neurohypophysitis. [PDF]

Case Rep Endocrinol
Background. Gestational diabetes insipidus (DI) is a very rare complication of pregnancy. We present a case of gestational DI combining two different types of DI. Case Presentation. A 39‐year‐old pregnant woman suddenly presented with thirst, polydipsia, and polyuria after 31 gestation weeks (GWs).
Yanagisawa S, Oikawa Y, Endo M, Inoue K, Nakajima R, Yasuda S, Sato M, Iwata N, Fujisawa H, Suzuki A, Sugimura Y, Isshiki M, Shimada A.   +12 more
europepmc   +2 more sources

Urinary aminopeptidase activities as early and predictive biomarkers of renal dysfunction in cisplatin-treated rats. [PDF]

PLoS ONE, 2012
This study analyzes the fluorimetric determination of alanyl- (Ala), glutamyl- (Glu), leucyl-cystinyl- (Cys) and aspartyl-aminopeptidase (AspAp) urinary enzymatic activities as early and predictive biomarkers of renal dysfunction in cisplatin-treated ...
Andrés Quesada, Félix Vargas, Sebastián Montoro-Molina, Francisco O'Valle, María Dolores Rodríguez-Martínez, Antonio Osuna, Isabel Prieto, Manuel Ramírez, Rosemary Wangensteen   +8 more
doaj   +1 more source

From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase

Frontiers in Pharmacology, 2020
It was reported three decades ago that intracerebroventricular injection of angiotensin IV (Ang IV, Val-Tyr-Ile-His-Pro-Phe) improved memory and learning in the rat. There are several explanations for these positive effects of the hexapeptide and related
Mathias Hallberg, Mats Larhed
doaj   +1 more source

Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia

Journal of Extracellular Vesicles, Volume 12, Issue 12, December 2023., 2023
Abstract Periodontitis is a chronic inflammatory disease caused by periodontal pathogens in subgingival plaque and is associated with systemic inflammatory diseases. Extracellular vesicles (EVs) released from host cells and pathogens carry a variety of biological molecules and are of interest for their role in disease progression and as diagnostic ...
Younggap Lim, Hyun Young Kim, Dohyun Han, Bong‐Kyu Choi   +3 more
wiley   +1 more source

Exploring the role of ex vivo metabolism on blood and plasma measurements of oxytocin among women in the third stage of labour: A post hoc study

British Journal of Clinical Pharmacology, Volume 89, Issue 12, Page 3669-3680, December 2023., 2023
Aims To examine the role of ex vivo oxytocin metabolism in post‐dose peptide measurements. Methods The stability of oxytocin (Study 1) and oxytocinase activity (Study 2) in late‐stage pregnancy blood was quantified using liquid‐chromatography tandem mass‐spectrometry (LC–MS/MS) and a fluorogenic assay, respectively.
Victoria L. Oliver, Sarah Siederer, Anthony Cahn, Katarzyna Gajewska‐Knapik, Rachel A. Gibson, Cleo Goodall, Carl Kirkpatrick, Jack Murray, Tri‐Hung Nguyen, Ian Schneider, Pete Lambert, Michelle P. McIntosh, Simon Parry   +12 more
wiley   +1 more source

The aminopeptidase LAP3 suppression accelerates myogenic differentiation via the AKT‐TFE3 pathway in C2C12 myoblasts

Journal of Cellular Physiology, Volume 238, Issue 9, Page 2103-2119, September 2023., 2023
We identified APP1, DNPEP, LAP3, LNPEP, METAP1, METAP2, PSA, and RNPEPL1 as the aminopeptidases that are required for the myogenic differentiation of C2C12 myoblasts. Especially, the suppression of LAP3 inhibited proteasomal proteolysis and promotes the myogenic differentiation of C2C12 myoblasts through AKT/TFE3/Myogenin pathways.
Shion Osana, Yasuo Kitajima, Suzuki Naoki, Kazutaka Murayama, Hiroaki Takada, Ayaka Tabuchi, Yutaka Kano, Ryoichi Nagatomi   +7 more
wiley   +1 more source