Results 1 to 10 of about 100,040 (330)

The Effect of E. coli Uridine-Cytidine Kinase Gene Deletion on Cytidine Synthesis and Transcriptome Analysis [PDF]

Fermentation, 2022
Cytidine is an antiviral and anticancer drug intermediate, its primary method of manufacture being fermentation. Uridine-cytidine kinase (UCK) catalyzes the reverse process of phosphorylation of cytidine to produce cytidylic acid, which influences ...
Fengmin Liu, Tong Ye, Xiangjun Zhang, Cong Ma, Huiyan Liu, Haitian Fang   +5 more
doaj   +2 more sources

Potential SARS-CoV-2 RdRp inhibitors of cytidine derivatives: Molecular docking, molecular dynamic simulations, ADMET, and POM analyses for the identification of pharmacophore sites.

PLoS ONE, 2022
The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 is one of the optimum targets for antiviral drug design and development. The hydroxyl groups of cytidine structures were modified with different aliphatic and aromatic groups to obtain 5´-O-acyl and 2´
Sarkar M A Kawsar, Mohammed A Hosen, Sajjad Ahmad, Youness El Bakri, Hamid Laaroussi, Taibi Ben Hadda, Faisal A Almalki, Yasuhiro Ozeki, Souraya Goumri-Said   +8 more
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APOBEC3A is a prominent cytidine deaminase in breast cancer.

PLoS Genetics, 2019
APOBEC cytidine deaminases are the second-most prominent source of mutagenesis in sequenced tumors. Previous studies have proposed that APOBEC3B (A3B) is the major source of mutagenesis in breast cancer (BRCA).
Luis M Cortez, Amber L Brown, Madeline A Dennis, Christopher D Collins, Alexander J Brown, Debra Mitchell, Tony M Mertz, Steven A Roberts   +7 more
doaj   +2 more sources

Crystal Structure of Cytidine [PDF]

Nature, 1949
A STUDY of the crystal structure of cytidine is being carried out by X-ray analysis. The crystal specimens were kindly supplied by Dr. D. O. Jordan, University of Nottingham, and were found to be orthorhombic with {110} dominating. An optical investigation shows that the sign is positive, with α∥c, β∥b and γ∥a Cell dimensions are : a = 13·93 A., b = 14·
Sven Furberg
openaire   +3 more sources

Cytidine Deaminase [PDF]

Definitions, 2020
Cytidine deaminase (146 aa, ~16 kDa) is encoded by the human CDA gene. This protein is involved in the deamination of cytidine and deoxycytidine to uridine and deoxyuridine ...
Cytidine Deaminase
openaire   +2 more sources

Promoting cytidine biosynthesis by modulating pyrimidine metabolism and carbon metabolic regulatory networks in Bacillus subtilis [PDF]

Microbial Cell Factories
Background The modification of single or multiple genes via metabolic engineering can lead to the dysregulation of central metabolism and affect bacterial growth and metabolite accumulation.
Xiangjun Zhang, Lu Liu, Pilian Niu, Tong Ye, Wei Ding, Xiaobo Wei, Junnan Xu, Haitian Fang, Huiyan Liu   +8 more
doaj   +2 more sources

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

Nature Communications, 2017
Cytidine deaminases are evolutionarily conserved enzymes that edit genomes by deaminating cytidine to uridine. Here the authors present the crystal structure of APOBEC3A with a single-stranded DNA substrate bound in the active site to shed light on the ...
Takahide Kouno, Tania V. Silvas, Brendan J. Hilbert, Shivender M. D. Shandilya, Markus F. Bohn, Brian A. Kelch, William E. Royer, Mohan Somasundaran, Nese Kurt Yilmaz, Hiroshi Matsuo, Celia A. Schiffer   +10 more
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Double-strand break-free and transgene-free genome editing in the microalga Nannochloropsis oceanica using removable vectors containing the CRISPR base editing system [PDF]

Scientific Reports
The accumulation of lipids by algae makes them attractive for carbon-neutral fuel production; however, the industrial-scale production of algal lipids has yet to be achieved.
Keishi Moroi, Takashi Yamamoto, Tomokazu Kurita   +2 more
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Integrated amplification of NADPH-regenerating modules enhances cytidine biosynthesis in Escherichia coli [PDF]

Synthetic and Systems Biotechnology
In Escherichia coli, cofactor imbalance serves as a crucial limiting factor in cytidine biosynthesis, with nicotinamide adenine dinucleotide phosphate (NADPH) insufficiency representing the principal metabolic barrier.
Lu Liu, Xiangjun Zhang, Tengteng Zhu, Tong Ye, Zongqian Li, Wei Ding, Huiyan Liu, Haitian Fang   +7 more
doaj   +2 more sources

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

Nature Biotechnology, 2017
Base editing induces single-nucleotide changes in the DNA of living cells using a fusion protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine deaminase, and an inhibitor of base excision repair.
Y. Bill Kim, Alexis C. Komor, Jonathan M. Levy, Michael S. Packer, Kevin T. Zhao, David R. Liu   +5 more
openalex   +3 more sources