Results 11 to 20 of about 100,040 (330)

Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model [PDF]

Future Science OA
Aims To evaluate the analgesic and neuroprotective effects of cytidine, uridine, and gabapentin—administered alone and in combination—in models of diabetic neuropathy and formalin-induced acute and inflammatory pain.Materials & Methods Oral doses of ...
Esam Y. Qnais, Muna Barakat, Rabaa Y. Athamneh, Mohammad A. A. Al-Najjar, Lujain F. Alzaghari, Dinesh Kumar Chellappan, Abdelrahim Alqudah   +6 more
doaj   +2 more sources

AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates

Nature Communications, 2018
The AID/APOBEC cytidine deaminase family are nucleic acid editors, important for antigen receptor expression and thought to have evolved along with vertebrate adaptive immunity.
Mei-Chen Liu, Wen-Yun Liao, Katherine M. Buckley, Shu Yuan Yang, Jonathan P. Rast, Sebastian D. Fugmann   +5 more
doaj   +2 more sources

Increased distribution of carbon metabolic flux during de novo cytidine biosynthesis via attenuation of the acetic acid metabolism pathway in Escherichia coli [PDF]

Microbial Cell Factories
Acetic acid, a by-product of cytidine synthesis, competes for carbon flux from central metabolism, which may be directed either to the tricarboxylic acid (TCA) cycle for cytidine synthesis or to overflow metabolites, such as acetic acid.
Tong Ye, Wei Ding, Zhengxu An, Haojie Zhang, Xiaobo Wei, Junnan Xu, Huiyan Liu, Haitian Fang   +7 more
doaj   +2 more sources

Transdifferentiation of α-1,3-galactosyltransferase knockout pig bone marrow derived mesenchymal stem cells into pancreatic -like cells by microenvironment modulation [PDF]

Asian-Australasian Journal of Animal Sciences, 2020
Objective To evaluate the pancreatic differentiation potential of α-1,3-galactosyltransferase knockout (GalTKO) pig-derived bone marrow-derived mesenchymal stem cells (BM-MSCs) using epigenetic modifiers with different pancreatic induction media. Methods
Imran Ullah, Ran Lee, Keon Bong Oh, Seongsoo Hwang, Youngim Kim, Tai-Young Hur, Sun A Ock   +6 more
doaj   +1 more source

Microwave-Assisted Synthesis of 5′-O-methacryloylcytidine Using the Immobilized Lipase Novozym 435

Molecules, 2022
Nucleobase building blocks have been demonstrated to be strong candidates when it comes to DNA/RNA-like materials by benefiting from hydrogen bond interactions as physical properties. Modifying at the 5′ position is the simplest way to develop nucleobase-
Sany Chea, Khac Toan Nguyen, Ruben R. Rosencrantz   +2 more
doaj   +1 more source

N4-acetylation of cytidine in (m)RNA plays essential roles in plants.

The Plant Cell, 2023
The biological function of RNA can be modulated by base modifications. Here, we unveiled the occurrence of N4-acetylation of cytidine in plant RNA, including mRNA, by employing LC-MS/MS and acRIP-seq.
Wenlei Wang, Huijie Liu, Feifei Wang, Xiaoye Liu, Yu Sun, Jie Zhao, Changhua Zhu, L. Gan, Jinping Yu, C. Witte, Mingjia Chen   +10 more
semanticscholar   +1 more source

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

Nature Biomedical Engineering, 2021
Base editors are RNA-programmable deaminases that enable precise single-base conversions in genomic DNA. However, off-target activity is a concern in the potential use of base editors to treat genetic diseases.
L. Villiger, Tanja Rothgangl, D. Witzigmann, Rurika Oka, Paulo J. C. Lin, W. Qi, Sharan Janjuha, Christian Berk, F. Ringnalda, Mitchell Beattie, M. Stoffel, B. Thöny, Jonathan Hall, H. Rehrauer, R. van Boxtel, Ying K. Tam, Gerald Schwank   +16 more
semanticscholar   +1 more source

A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

Nature, 2020
Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found ...
Beverly Mok, Beverly Mok, B. Mok, Marcos H. de Moraes, J. Zeng, D. Bosch, Anna V. Kotrys, Anna V. Kotrys, Anna V. Kotrys, Aditya Raguram, Aditya Raguram, Aditya Raguram, F. Hsu, M. Radey, S. B. Peterson, V. Mootha, V. Mootha, J. D. Mougous, David R. Liu, David R. Liu, David R. Liu   +20 more
semanticscholar   +1 more source

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir

Journal of the American Chemical Society, 2022
The Covid-19 pandemic highlights the urgent need for cost-effective processes to rapidly manufacture antiviral drugs at scale. Here we report a concise biocatalytic process for Molnupiravir, a nucleoside analogue recently approved as an orally available ...
A. Burke, W. Birmingham, Y. Zhuo, T. Thorpe, Bruna Zucoloto da Costa, R. Crawshaw, I. Rowles, J. Finnigan, C. Young, Gregory M Holgate, M. P. Muldowney, S. Charnock, S. Lovelock, N. Turner, A. Green   +14 more
semanticscholar   +1 more source

Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase. [PDF]

PLoS ONE, 2013
Deamination of 5-methylcytidine (5MeC) in DNA results in a G:T mismatch unlike cytidine (C) deamination which gives rise to a G:U pair. Deamination of C was generally considered to arise spontaneously.
Rodolphe Suspène, Marie-Ming Aynaud, Jean-Pierre Vartanian, Simon Wain-Hobson   +3 more
doaj   +1 more source