Results 31 to 40 of about 100,040 (330)
Cell Death Discovery, 2022 Highly specific and potent inhibitors of dihydroorotate dehydrogenase (DHODH), an essential enzyme of the de novo pyrimidine ribonucleotide synthesis pathway, are in clinical trials for autoimmune diseases, viral infections and cancer.
Twana Alkasalias +9 more
doaj +1 more source
The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer [PDF]
, 2012 Carboplatin remains a first-line agent in the management of epithelial ovarian cancer (EOC). Unfortunately, platinum-resistant disease ultimately occurs in most patients.
A Bali +27 more
core +1 more source
Phosphorylation of purine and pyrimidine nucleosides by isolated rat liver mitochondria [PDF]
, 1975 Formation of 5'-AMP, 5'-GMP, 5'-CMP and 5'UMP was confirmed in isolated rat liver mitochondria incubated with alpha-ketoglutarate, inorganic phosphate, purine nucleoside and pyrimidine nucleoside. Increased incorporation of 32Pi into ATP, GTP and UTP was
Inaba, Kozo, Oda, Takuzo
core +1 more source
International Journal of Molecular Sciences, 2019 Genome editing tools have rapidly been adopted by plant scientists for gene function discovery and crop improvement. The current technical challenge is to efficiently induce precise and predictable targeted point mutations valuable for crop breeding ...
F. Veillet +7 more
semanticscholar +1 more source
Indispensable residue for uridine binding in the uridine-cytidine kinase family
Biochemistry and Biophysics Reports, 2017 Uridine-cytidine kinase (UCK), including human UCK2, are a family of enzymes that generally phosphorylate both uridine and cytidine. However, UCK of Thermus thermophilus HB8 (ttCK) phosphorylates only cytidine.
Fumiaki Tomoike +5 more
doaj +1 more source
iScience, 2022 Summary: APOBEC3 family members are cytidine deaminases catalyzing conversion of cytidine to uracil. Many studies have established a link between APOBEC3 expression and cancer development and progression, especially APOBEC3A (A3A) and APOBEC3B (A3B ...
Christina Papini +12 more
doaj +1 more source
15N NMR study of a mixture of uniformly labeled tRNAs [PDF]
, 1982 15N NMR spectra were taken of 15N-enriched tRNA extracted from bakers yeast; ammonium sulfate was used as a nitrogen source. The increase in the degree of denaturation of tRNA, which occurs with increase in temperature from 30 degrees C to 70 degrees C ...
Birdseye, Theresa R. +3 more
core +1 more source
Gastroprotective effects of oral nucleotide administration [PDF]
, 2006 BACKGROUND AND AIMS: Nucleotides form the building blocks of DNA and are marketed as dietary supplements, alone or in combination with other ingredients, to promote general health.
Belo, A +4 more
core +2 more sources
An enzymatic assay for high-throughput screening of cytidine-producing microbial strains.
PLoS ONE, 2015 Cytidine is an industrially useful precursor for the production of antiviral compounds and a variety of industrial compounds. Interest in the microbial production of cytidine has grown recently and high-throughput screening of cytidine over-producers is ...
Huina Dong +5 more
doaj +1 more source
Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution [PDF]
, 2015 Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of immunoglobulin variable (IgV) and switch region (IgS) DNA ...
Bertram, JG +7 more
core +1 more source