Results 41 to 50 of about 100,040 (330)
Increasing fidelity and efficiency by modifying cytidine base-editing systems in rice
Crop Journal, 2020 The efficiency of plant cytidine base-editing systems is limited, and unwanted mutations frequently occur in transgenic plants. We increased the cytidine editing frequency and fidelity of the plant base editor 3 (BE3) and targeted activation-induced ...
Ruiying Qin +6 more
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Aquaculture Reports, 2022 Economic crustaceans play important roles in aquaculture and create great benefits for the world agricultural economy. Studies have found that there are many single nucleotide polymorphism (SNP) sites in the crustacean genomes, which closely related to a
Yujie Liu +5 more
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A concise route to MK-4482 (EIDD-2801) from cytidine.
Chemical Communications, 2020 A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine. The selective acylation and direct amination eliminate the need for protecting and activating groups and proceed in overall yield of
Vasudevan Natarajan +10 more
semanticscholar +1 more source
The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2. [PDF]
PLoS ONE, 2016 Fluorocyclopentenylcytosine (RX-3117) is an orally available cytidine analog, currently in Phase I clinical trial. RX-3117 has promising antitumor activity in various human tumor xenografts including gemcitabine resistant tumors.
Dzjemma Sarkisjan +8 more
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Observation of coherent delocalized phonon-like modes in DNA under physiological conditions [PDF]
, 2016 Underdamped terahertz-frequency delocalized phonon-like modes have long been suggested to play a role in the biological function of DNA. Such phonon modes involve the collective motion of many atoms and are prerequisite to understanding the molecular ...
Ellis, Elizabeth M. +6 more
core +1 more source
Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers
Cell Reports, 2022 Summary: Mutational signatures defined by single base substitution (SBS) patterns in cancer have elucidated potential mutagenic processes that contribute to malignancy.
Rachel A. DeWeerd +7 more
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Chemical investigation of light induced DNA bipyrimidine damage and repair [PDF]
, 2011 In all organisms, genetic information is stored in DNA and RNA. Both of these macromolecules are damaged by many exogenous and endogenous events, with UV irradiation being one of the major sources of damage.
Carell, Thomas +2 more
core +1 more source
PharmaceuticalsCytarabine (Ara-C) is a synthetic isomer of cytidine that differs from cytidine and deoxycytidine only in the sugar. The use of arabinose instead of deoxyribose hinders the formation of phosphodiester linkages between pentoses, preventing the DNA chain ...
Jolanta Natalia Latosińska +4 more
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Genes & Development, 2019 In this study, Vitali et al. demonstrate that 2′-O-methylation of the C34 wobble cytidine of human elongator tRNAMet(CAT) is achieved by collaboration of a nucleolar and a CB-specific box C/D RNP carrying the SNORD97 and SCARNA97 box C/D 2′-O-methylation
Patrice Vitali, T. Kiss
semanticscholar +1 more source
Journal of Pain Research, 2020 Marco Antonio Naslausky Mibielli,1 Carlos Pereira Nunes,1,2 Henrique Goldberg,3 Luiz Buchman,2 Lisa Oliveira,4 Spyros GE Mezitis,5 Fernanda Wajnzstajn,6 Renato Kaufman,3 Rafael Nigri,7 Natasha Cytrynbaum,3 Karin Soares Cunha,8 Alessandra Santos,4 ...
Mibielli MAN +17 more
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