Gender effects on cytidine analogue metabolism and myelodysplastic syndrome treatment outcomes [PDF]
, 2012 In vivo, half-lives of cytidine analogues such as 5-azacytidine and decitabine, used to treat myelodysplastic syndromes (MDS), are determined largely by cytidine deaminase (CDA), an enzyme that rapidly metabolizes these drugs into inactive uridine ...
Ania Jankowska +13 more
core +1 more source
A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium, and hydroxocobalamin, versus isolated treatment with hydroxocobalamin, in patients presenting with compressive neuralgias [PDF]
, 2017 CONTEXT: This paper reports on the results of treatment of compressive neuralgia using a combination of nucleotides (uridine triphosphate trisodium [UTP] and cytidine monophosphate disodium [CMP]) and vitamin B(12).
Buchman, Luiz +9 more
core +2 more sources
Nature Communications, 2017 Cytidine deaminases are evolutionarily conserved enzymes that edit genomes by deaminating cytidine to uridine. Here the authors present the crystal structure of APOBEC3A with a single-stranded DNA substrate bound in the active site to shed light on the ...
Takahide Kouno +10 more
doaj +1 more source
Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID
Nature Communications, 2018 CRISPR-guided cytidine deaminases, including BE3 (Base Editor 3) and Target-AID (activation-induced cytidine deaminase), can covert C:G base pairs to T:A at target site.
Hiroki Sasaguri +9 more
doaj +1 more source
The antilymphocytic activity of brequinar sodium and its potentiation by cytidine: Effects on lymphocyte proliferation and cytokine production [PDF]
, 1993 Based on its capacity to inhibit de novo pyrimidine biosynthesis by blocking dihydroorotate dehydrogenase activity, the antitumor agent brequinar sodium (BQR) has emerged as a new immunosuppressive agent.
Lemster, B +4 more
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DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]
, 2017 Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A +2 more
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eLife, 2014 The activation induced cytidine deaminase (AID) protein is known to initiate somatic hypermutation, gene conversion or switch recombination by cytidine deamination within the immunoglobulin loci.
Jean-Marie Buerstedde +2 more
doaj +1 more source
Cytidine does not affect acute toxicity of intravenously administered choline
Folia NeuropathologicaCytidine-5’-diphosphocholine (CDP-choline) is a key precursor for the intracellular synthesis of phosphatidylcholine and other phospholipids. Following either intravenous or oral application citicoline (CDP-choline of exogenous origin) undergoes quick ...
Kamil Synoradzki +2 more
doaj +1 more source
Observation of coherent delocalized phonon-like modes in DNA under physiological conditions [PDF]
, 2016 Underdamped terahertz-frequency delocalized phonon-like modes have long been suggested to play a role in the biological function of DNA. Such phonon modes involve the collective motion of many atoms and are prerequisite to understanding the molecular ...
Ellis, Elizabeth M. +6 more
core +1 more source
AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates
Nature Communications, 2018 The AID/APOBEC cytidine deaminase family are nucleic acid editors, important for antigen receptor expression and thought to have evolved along with vertebrate adaptive immunity.
Mei-Chen Liu +5 more
doaj +1 more source