A new technique for the analysis of metabolic pathways of cytidine analogues and cytidine deaminase activities in cells [PDF]
Scientific Reports, 2023 Deoxycytidine analogues (dCas) are widely used for the treatment of malignant diseases. They are commonly inactivated by cytidine deaminase (CDD), or by deoxycytidine monophosphate deaminase (dCMP deaminase).
Anna Ligasová +3 more
doaj +2 more sources
Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report [PDF]
BMC Cancer, 2020 Background Pancreatic adenosquamous carcinoma has a poor prognosis, with limited prospective trial data to guide optimal treatment. The potential impact of drug metabolism on the treatment response of patients with pancreatic adenosquamous carcinoma is ...
Claire M. Connell +8 more
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Cytidine deaminase-dependent mitochondrial biogenesis as a potential vulnerability in pancreatic cancer cells [PDF]
Communications BiologyCytidine deaminase (CDA) converts cytidine and deoxycytidine into uridine and deoxyuridine as part of the pyrimidine salvage pathway. Elevated levels of CDA are found in pancreatic tumors and associated with chemoresistance. Recent evidence suggests that
Audrey Frances +15 more
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APOBEC3A is a prominent cytidine deaminase in breast cancer. [PDF]
PLoS Genetics, 2019 APOBEC cytidine deaminases are the second-most prominent source of mutagenesis in sequenced tumors. Previous studies have proposed that APOBEC3B (A3B) is the major source of mutagenesis in breast cancer (BRCA).
Luis M Cortez +7 more
doaj +2 more sources
Lack of activation-induced cytidine deaminase expression in in situ follicular neoplasia. [PDF]
Haematologica, 2021 Goyal T +4 more
europepmc +3 more sources
Programmable Base Editing in Mycobacterium tuberculosis Using an Engineered CRISPR RNA-Guided Cytidine Deaminase. [PDF]
Front Genome Ed, 2021 Ding XY +6 more
europepmc +2 more sources
Sustained activation induced cytidine deaminase (AID) expression in B cells following Plasmodium falciparum malaria infection in Kenyan children. [PDF]
J ImmunolAriera B +9 more
europepmc +3 more sources
Highly Efficient CRISPR-Mediated Base Editing in Sinorhizobium meliloti
Frontiers in Microbiology, 2021 Rhizobia are widespread gram-negative soil bacteria and indispensable symbiotic partners of leguminous plants that facilitate the most highly efficient biological nitrogen fixation in nature.
Longxiang Wang +6 more
doaj +1 more source
Partial purification of cytidine deaminase from protoscoleces of Echinococcus granulosus [PDF]
Kirkuk Journal of Science, 2015 Cytidine deaminase (EC 3.5.4.5) has been partially purified from protoscoleces of Echinococcus granulosus by gel filteration chromatography using Sephadex G200 .The molecular weight of the enzyme determined by gel filteration was about 82000 dalton with ...
Husain F. Hassan, Jenan A.Saber
doaj +1 more source
CCCTC-binding factor locks premature IgH germline transcription and restrains class switch recombination [PDF]
, 2017 In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA.
Marina-Zárate, Ester +2 more
core +12 more sources