Results 21 to 30 of about 2,416 (164)

Expression of Human Thrombomodulin Prevents Early Thrombocytopenia and Thrombotic Microangiopathy in Pig-to-Nonhuman Primate Orthotopic Liver Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Background Severe thrombocytopenia and coagulation dysregulation remain major barriers to survival in pig‐to‐primate liver xenotransplantation models. Methods Porcine livers with five genetic modifications (GTKO, CMAHKO, β4GalNT2KO, hCD55, and hTBM) were orthotopically transplanted into four Tibetan macaques under two conventional ...
Zhang Z, Li T, Li Q, Xie B, Zhao X, Wang J, Huang Y, Luo J, Wen S, Zhou Y, Deng Y, Lu Y, Jiang Y, Li J, Cooper DKC, Pan D, Si Z, Qi H.   +17 more
europepmc   +2 more sources

Metabolomic Insights Into the Impact of a Maternal Western-Style Diet and Leptin Supplementation During Suckling on Adult Rat Offspring. [PDF]

FASEB J
Plasma metabolites in adult offspring reflecting metabolic programming during critical developmental windows. ABSTRACT Perinatal nutrition influences offspring metabolic phenotype and obesity risk. This study examines how a maternal obesogenic diet and offspring's leptin supplementation during suckling affect the metabolome in offspring adulthood ...
Pomar CA, Martin-Chamorro RA, Zouhar P, Castillo P, Cajka T, Kopecky J, Palou A, Palou M, Picó C.   +8 more
europepmc   +2 more sources

Tumor desialylation surpasses anti-PD-L1 checkpoint therapy in restoring anti-tumor immunity in a murine model for colorectal cancer. [PDF]

Int J Cancer
What's new? Our research highlights how tumor sialylation affects tumor growth and reshapes the immune tumor microenvironment in colorectal cancer. We demonstrate for the first time that complete removal of sialic acids from colorectal tumor cells elicits a robust anti‐tumor immune response, but does not enhance anti‐PD‐L1 blockade efficacy.
van der Haar Àvila I, Zhang T, Lorrain V, Keuning E, Ali LA, Chadick C, García-García S, Boon L, de Haan N, García-Vallejo JJ, van Kooyk Y, van Vliet SJ.   +11 more
europepmc   +2 more sources

CRISPR editing of candidate host factors that impact influenza A virus infection [PDF]

Microbiology Spectrum
Influenza A virus (IAV) is a respiratory pathogen with a segmented negative-sense RNA genome that can cause epidemics and pandemics. The host factors required for the complete IAV infectious cycle have not been fully identified.
Pyae Phyo Kyawe, Ping Liu, Zhaozhao Jiang, Evan S. Bradley, Thomas Cicuto, Melanie I. Trombly, Neal Silverman, Katherine A. Fitzgerald, William M. McDougall, Jennifer P. Wang   +9 more
doaj   +2 more sources

Prevalence of a Novel Immunogenic Feline Erythrocyte Antigen (FEA 6) and Expression Patterns Between FEAs. [PDF]

J Vet Intern Med
ABSTRACT Background After the identification of five novel feline erythrocyte antigens (FEAs) and evidence establishing FEA 1's immunogenicity, attempts to sensitize a cat to FEA 4 unexpectedly resulted in the production of alloantibodies directed against an unknown antigen, named FEA 6.
Bajon F, Arsenault J, Blais MC.
europepmc   +2 more sources

Short communications. Enzymic degradation of cytidine 5'-monophosphate N-acetylneuraminic acid.

The Biochemical journal, 1967
M, Shoyab, B K, Bachhawat
openaire   +3 more sources

Multiple gene editing in porcine embryos using a combination of microinjection, electroporation, and transfection methods [PDF]

Veterinary World, 2022
Background and Aim: Mosaicism – the presence of both wild-type and mutant alleles – is a serious problem for zygotic gene modification through gene editing using the Clustered regularly interspaced short palindromic repeats-Cas9 (CRISPR/ Cas9) system ...
Quynh Anh Le, Manita Wittayarat, Zhao Namula, Qingyi Lin, Koki Takebayashi, Maki Hirata, Fuminori Tanihara, Lanh Thi Kim Do, Takeshige Otoi   +8 more
doaj   +1 more source

N-Glycolylneuraminic Acid in Animal Models for Human Influenza A Virus

Viruses, 2021
The first step in influenza virus infection is the binding of hemagglutinin to sialic acid-containing glycans present on the cell surface. Over 50 different sialic acid modifications are known, of which N-acetylneuraminic acid (Neu5Ac) and N ...
Cindy M. Spruit, Nikoloz Nemanichvili, Masatoshi Okamatsu, Hiromu Takematsu, Geert-Jan Boons, Robert P. de Vries   +5 more
doaj   +1 more source

N-glycolylneuraminic acid as a carbohydrate cancer biomarker

Translational Oncology, 2023
One of the forms of aberrant glycosylation in human tumors is the expression of N-glycolylneuraminic acid (Neu5Gc). The only known enzyme to biosynthesize Neu5Gc in mammals, cytidine-5′-monophosphate-N-acetylneuraminic acid (CMAH), appears to be ...
Jing Wang, Lucy K. Shewell, Christopher J. Day, Michael P. Jennings   +3 more
doaj   +1 more source

Protein engineering of CMP kinases to improve thermal stability and resultant production of 3′-sialyllactose

Biotechnology & Biotechnological Equipment, 2022
Protein engineering is an effective method to improve the thermal stability of biological macromolecules. Cytidine monophosphate kinase (CMK) is a key enzyme involved in nucleotide metabolism and participates in the production of cytidine triphosphate ...
Jingjing Wang, Jinyong Wu, Zhongkui Li, Xiangsong Chen, Weiwei Liu, Jianming Yao   +5 more
doaj   +1 more source