Results 41 to 50 of about 2,416 (164)
Frontiers in Immunology, 2022 Kidney xenotransplantation is expected to contribute to resolving the shortage of kidneys from deceased human donors. Although progress in experimental life-supporting pig renal xenotransplantation has been encouraging, there are still issues to be ...
Tao Li +13 more
doaj +1 more source
Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides. [PDF]
, 2019 Sialic acids constitute a family of negatively charged structurally diverse monosaccharides that are commonly presented on the termini of glycans in higher animals and some microorganisms.
Chen, Xi +2 more
core +2 more sources
Scalable multi-enzyme platforms for the in vitro glycoengineering of therapeutic proteins & synthesis of human milk oligosaccharides [PDF]
, 2022 Sugars in their free form or conjugated to biomolecules like proteins, lipids, and small molecules have significant functional roles in different biological processes.
Mahour, R.
core +2 more sources
Erythrocytes from GGTA1/CMAH knockout pigs: implications for xenotransfusion and testing in non-human primates [PDF]
, 2014 Background Pig erythrocytes are potentially useful to solve the worldwide shortage of human blood for transfusion. Domestic pig erythrocytes, however, express antigens that are bound by human preformed antibodies.
Burlak, Christopher +6 more
core +1 more source
Metabolic engineering of microbes for oligosaccharide and polysaccharide synthesis [PDF]
, 2006 Metabolic engineering has recently been embraced as an effective tool for developing whole-cell biocatalysts for oligosaccharide and polysaccharide synthesis.
Anne Ruffing, Rachel Chen
core +1 more source
B4GALNT2 and xenotransplantation: A newly appreciated xenogeneic antigen [PDF]
, 2018 Analysis of non-Gal antibody induced after pig-to-baboon cardiac xenotransplantation identified the glycan produced by porcine beta-1,4-N-acetyl-galactosaminyltransferase 2 (B4GALNT2) as an immunogenic xenotransplantation antigen.
Ahmad-Villiers, S +3 more
core +1 more source
Scientific Reports, 2018 Sialylation of recombinant therapeutic glycoproteins modulates their pharmacokinetic properties by affecting their in vivo half-life. N-glycan branching on glycoproteins increases the number of potential attachment sites for sialic acid.
Chung-Geun Lee +4 more
doaj +1 more source
Characterization of antibody binding to swine leukocyte antigen class II [PDF]
, 2016 Indiana University-Purdue University Indianapolis (IUPUI)Though the elimination of carbohydrate xenoantigens has reduced the antibody barrier to clinical xenotransplantation, identification of additional targets of rejection could further increase the ...
Ladowski, Joseph Matthew
core +1 more source
Xenotransplantation: past, present, and future [PDF]
, 2017 PURPOSE OF REVIEW: To review the progress in the field of xenotransplantation with special attention to most recent encouraging findings which will eventually bring xenotransplantation to the clinic in the near future.
Cooper, David K.C. +2 more
core +1 more source
Expression of active human sialyltransferase ST6GalNAcI in Escherichia coli [PDF]
, 2009 Georgios Skretas, Sean Carroll, and George Georgiou are with the Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA -- George Georgiou is with the Department of Biomedical Engineering, University of Texas at Austin ...
George Georgiou +5 more
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