Results 71 to 80 of about 1,917 (174)

Immunobiological barriers to xenotransplantation [PDF]

, 2015
Binding of natural anti-pig antibodies in humans and nonhuman primates to carbohydrate antigens expressed on the transplanted pig organ, the most important of which is galactose-α1,3-galactose (Gal), activate the complement cascade, which results in ...
Cooper, David K. C., Ekser, Burcin, Tector, A. Joseph   +2 more
core   +1 more source

Characterizing coagulation responses in humans and nonhuman primates following kidney xenotransplantation—A narrative review

American Journal of Hematology, Volume 100, Issue 2, Page 285-295, February 2025.
Abstract The recent report of the first pig kidney transplant in a living human brings hope to thousands of people with end‐stage kidney failure. The scientific community views this early success with caution as kidney xenotransplantation exhibits many challenges and barriers. One of these is coagulation dysregulation.
Ali Zidan, Adham H. El‐Sherbini, Abdelrahman Noureldin, David K. C. Cooper, Maha Othman   +4 more
wiley   +1 more source

A Novel Missense Variant in Ultrarare SLC35A1‐CDG Alters Cellular Glycosylation, Lipid, and Energy Metabolism Without Affecting CDG Serum Markers

Human Mutation, Volume 2025, Issue 1, 2025.
SLC35A1‐CDG is a very rare type of congenital disorders of glycosylation (CDG) with only five cases known to date. Here, we review the literature and present new data from a sixth patient carrying the uncharacterized variant c.133A>G; p.Thr45Ala in the SLC35A1 gene.
Kristina Falkenstein, Lukas Hoeren, Frauke Kikul, Gernot Poschet, Christian Lüchtenborg, Ines B. Brecht, Ruth Falb, Darja Gauck, Tobias Haack, Andreas Hecker, Nastassja Himmelreich, Jürgen G. Okun, Britta Brügger, Christian Thiel, Aziz ur Rehman. Aziz   +14 more
wiley   +1 more source

Exploring the multifaceted role of GNE in GNE myopathy [PDF]

101080249) and the Canada Research Coordinating Committee New Frontiers in Research Fund (NFRFG-2022-00033) for SIMPATHIC, and from the Government of Canada First Research Excellence Fund (CFREF) for the Brain-Heart Interconnectome (CFREF-2022-00007 ...
Barbosa, Mariana, Granjo, Pedro, Lochmüller, Hanns, Pereira, Beatriz L., Videira, Paula A.   +4 more
core   +1 more source

Detection Strategies for Sialic Acid and Sialoglycoconjugates

ChemBioChem, Volume 25, Issue 23, December 2, 2024.
Sialic acid is a glycan residue found at the termini of many glycoconjugates. This residue, and the underlying residues it covers, form critical recognition epitopes in glycobiology. In this review we discuss methods to detect sialoglycoconjugates and sialic acids which are either substrates or products of the enzymes that form these conjugates ...
Carmanah D. Hunter, Christopher W. Cairo
wiley   +1 more source

Xenotransplantation in the Age of Genome Editing: Results From the Expert Report for the Federal Ethics Committee on Nonhuman Biotechnology With a Special Focus on Animal Ethics

Xenotransplantation, Volume 31, Issue 6, November/December 2024.
ABSTRACT Background The Federal Ethics Committee on Non‐Human Biotechnology (ECNH) of Switzerland is an independent expert committee appointed by the Federal Council and mandated to advise the federal authorities from an ethical perspective in the field of nonhuman biotechnology and gene technology.
Samuel Camenzind
wiley   +1 more source

N-Glycan structures and N-glycosylation sites of mouse soluble intercellular adhesion molecule-1 revealed by MALDI-TOF and FTICR mass spectrometry [PDF]

, 2017
Intercellular adhesion molecule-1 (ICAM-1) is a heavily N‐glycosylated transmembrane protein comprising five extracellular Ig-like domains. The soluble isoform of ICAM-1 (sICAM-1), consisting of its extracellular part, is elevated in the cerebrospinal ...
Ali, Sarah, Callewaert, Nico, Cueni, Leah N., Damoc, Eugen, Folkers, Gerd, Frei, Renate, Leary, Julie A., Moise, Adrian, Otto, Vivianne I., Przybylski, Michael, Schürpf, Thomas   +10 more
core  

Purification, cloning, and expression of a cytidine 5'-monophosphate N-acetylneuraminic acid synthetase from Haemophilus ducreyi.

The Journal of biological chemistry, 1996
An N-acetylneuraminic acid cytidylyltransferase (EC 2.7.7.43) (CMP-NeuAc synthetase) was isolated from a Haemophilus ducreyi strain 35000 cell lysate and partially characterized. The enzyme catalyzes the reaction of CTP and NeuAc to form CMP-NeuAc, which is the nucleotide sugar donor used by sialyltransferases.
M V, Tullius, R S, Munson, J, Wang, B W, Gibson   +3 more
openaire   +1 more source

Synthesis of sialoglycopolypeptide for potentially blocking influenza virus infection using a rat α2,6-sialyltransferase expressed in BmNPV bacmid-injected silkworm larvae [PDF]

, 2009
publishe
00397366, 1525, 1525, 2907, 2907, 2910, 2910, 2921, 2922, 2923, 2924, 2925, 2bfa7e53-ee2d-4af4-b215-37e9ff303ca8, 4d68973e-f6ff-4d7d-9439-c121d8831040, 50111802, 90238246, bd6a76a9-51e0-42ce-9e57-130004af2bc5, Kato, Koichi, Kato, Tatsuya, Nakajima, Makoto, Obara, Takakiyo, Ogata, Nakoto, Park, Enoch Y., Usui, Taichi, Yagi, Hirokazu   +24 more
core   +1 more source

A Correlation between Protein Function and Ligand Binding Profiles [PDF]

, 2011
We report that proteins with the same function bind the same set of small molecules from a standardized chemical library. This observation led to a quantifiable and rapidly adaptable method for protein functional analysis using experimentally-derived ...
Bokemper, Michael, Copeland, Jennifer C., Powers, Robert, Shortridge, Matthew D, Stark, Jaime L.   +4 more
core   +1 more source