Results 101 to 110 of about 46,080 (279)

Role of [Ca2+]i and F-actin on mesothelial barrier function

Frontiers in Physiology, 2014
The mesothelial layer acts as a biological barrier between the organ and the enveloping serous cavity and may have functions of transport, equilibrium maintenance, and protection.
Masayoshi eKuwahara
doaj   +1 more source

Exploring the Substitution of the C21-OAc Moiety in [11]Cytochalasans: Synthesis and Evaluation of Fluorophore Conjugates. [PDF]

Chembiochem
Via in silico docking of pyrichalasin H on G‐ and F‐actin, the C21‐OAc moiety is identified as a modifiable site tolerated for actin binding. Fluorescent [11]cytochalasan probes from pyrichalasin H and epoxycytochalasin C are obtained by selective C21‐OAc hydrolysis and acylation.
Kagho MD, Schmidt K, Chakrabarti A, Karger M, Lambert C, Hauser M, Cox RJ, Rottner K, Stadler M, Stradal TE, Klahn P.   +10 more
europepmc   +2 more sources

Reversal of MPPa‐PDT Resistance in Osteosarcoma by Targeting ROCK2‐Mediated Autophagy

Cell Proliferation, EarlyView.
ROCK2 competes with MST1 to bind to the aa 28‐198 region of SAV1 and then regulates the Hippo pathway to affect autophagy, resulting in the resistance of OS to MPPa‐PDT. Targeted inhibition of ROCK2 by screening for J059‐0149 increases the sensitivity of osteosarcoma to MPPa‐PDT. ABSTRACT Osteosarcoma (OS) is a primary bone tumour that occurs mostly in
Xuan Yi, Xueqiang Deng, Jianyong Deng, Chen Li, Hong Peng, Yunyan Du, Qing Li, Xiaohua Yan, Xin Hu, Yan Zheng, Shenliang Chen, Ting Xiong, Debin Xu, Leifeng Chen, Liang Hao   +14 more
wiley   +1 more source

Global Analysis of Predicted G Protein-Coupled Receptor Genes in the Filamentous Fungus, Neurospora crassa. [PDF]

, 2015
G protein-coupled receptors (GPCRs) regulate facets of growth, development, and environmental sensing in eukaryotes, including filamentous fungi. The largest predicted GPCR class in these organisms is the Pth11-related, with members similar to a protein ...
Ahrendt, Steven R, Barsoum, Andrew H, Borkovich, Katherine A, Cabrera, Ilva E, Cao, Jackie, Carrillo, Alexander J, Castillo, Ronald, Chen, Wan-Ching, Davidson, Liza M, Dinkchian, Alex, Guerrero, Nayeli, Kim, Stephanie, Kitada, Sho M, Krystofova, Svetlana, Lai, Taffani H, Li, Liande, Lim, Andrew, Mach, Ashley, Malekyan, Cristin, Michkov, Alexander V, Moua, Toua R, Pacentine, Itallia V, Servin, Jacqueline A, Torres, Carlos Rojas, Yamamoto, Alaina   +24 more
core  

Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation

Cell Proliferation, EarlyView.
Mechanical tension activates Drp1‐mediated mitochondrial fission in macrophages, facilitating the release of Mito‐EVs that are subsequently transferred to BMSCs. Additionally, the CD200R‐CD200 interaction enhances the uptake of these mechanically stimulated macrophage‐derived Mito‐EVs by BMSCs, ultimately promoting osteogenic differentiation.
Yingyi Li, Ziwei Yan, Yueming Dai, Hanjia Cai, Yue Chen, Yuyi Chen, Ruofan Jin, Wen Sun, Hua Wang   +8 more
wiley   +1 more source

A mouse model for improving cell survival of bisected cattle embryos

Agricultural and Food Science, 2008
Morula and blastocyst stage embryos recovered from B6D2F 1 mice were bisected with a metal microlabde in M2 medium with or without sucrose and/or cytochalasin B supplementation.
P. BREDBACKA
doaj  

Moving toward a higher efficiency of microcell-mediated chromosome transfer

Molecular Therapy: Methods & Clinical Development, 2016
Microcell-mediated chromosome transfer (MMCT) technology enables individual mammalian chromosomes, megabase-sized chromosome fragments, or mammalian artificial chromosomes that include human artificial chromosomes (HACs) and mouse artificial chromosomes (
Mikhail Liskovykh, Nicholas CO Lee, Vladimir Larionov, Natalay Kouprina   +3 more
doaj   +1 more source

In vitro markers for virulence in Yersinia ruckeri [PDF]

, 2010
In this study, different traits that have been associated with bacterial virulence were studied in Yersinia ruckeri. Two isolates that had been shown to cause disease and mortality in experimentally infected rainbow trout were compared with five ...
Chiers, Koen, Decostere, Annemie, Haesebrouck, Freddy, Hermans, Katleen, Tobback, Els, Van Den Broeck, Wim   +5 more
core   +2 more sources

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

A mouse model for improving cell survival of bisected cattle embryos

Agricultural and Food Science, 1996
Morula and blastocyst stage embryos recovered from B6D2F_1 mice were bisected with a metal microblade in M2 medium with or without sucrose and/or cytochalasin B supplementation.
Peter Bredbacka
doaj