Results 11 to 20 of about 19,108 (270)

Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus Xylaria curta E10 and Their Cytotoxicity [PDF]

Pharmaceuticals, 2023
Six previously undescribed cytochalasins, Curtachalasins X1–X6 (1–6), together with six known compounds (7–12) were isolated from the endophytic fungus Xylaria curta E10 harbored in the plant Solanum tuberosum.
Xian Zhang, Yinzhong Fan, Ke Ye, Xiaoyan Pan, Xujun Ma, Honglian Ai, Baobao Shi, Jikai Liu   +7 more
doaj   +2 more sources

Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, Isolated from a Diseased Torreya taxifolia Leaf

Molecules, 2019
Bioassay-guided fractionation of an EtOAc extract of the broth of the endophytic fungus Nemania sp. UM10M (Xylariaceae) isolated from a diseased Torreya taxifolia leaf afforded three known cytochalasins, 19,20-epoxycytochalasins C (1) and D (2), and 18 ...
Mallika Kumarihamy, Daneel Ferreira, Edward M. Croom, Rajnish Sahu, Babu L. Tekwani, Stephen O. Duke, Shabana Khan, Natascha Techen, N. P. Dhammika Nanayakkara   +8 more
doaj   +2 more sources

Antiproliferative and Cytotoxic Cytochalasins from Sparticola triseptata Inhibit Actin Polymerization and Aggregation [PDF]

Journal of Fungi, 2022
Laying the groundwork on preliminary structure–activity relationship study relating to the disruptive activity of cytochalasan derivatives on mammalian cell actin cytoskeleton, we furthered our study on the cytochalasans of the Dothideomycetes fungus ...
Katherine Yasmin M. Garcia, Mark Tristan J. Quimque, Christopher Lambert, Katharina Schmidt, Gian Primahana, Theresia E. B. Stradal, Andreas Ratzenböck, Hans-Martin Dahse, Chayanard Phukhamsakda, Marc Stadler, Frank Surup, Allan Patrick G. Macabeo   +11 more
doaj   +2 more sources

Discovery of Secondary Metabolites from the Sponge-Derived Fungus Aspergillus templicola [PDF]

Marine Drugs
Combining biosynthetic gene cluster analysis with the OSMAC strategy, fractionation of the fermentation extract of Aspergillus templicola from the sponge Agelas sp. led to the isolation of four novel cytochalasins, colachalasins J–M (1–4), a novel cyclic
Kai Li, Yue Zhang, Lei Li, Sen Wang, Cili Wang, Pinglin Li   +5 more
doaj   +2 more sources

Unconventional semi-solid cultivation enhances cytochalasins production by the Colombian fungus Xylaria sp. CM-UDEA-H199 [PDF]

BMC Biotechnology
Fungal species of the order Xylariales, particularly those from tropical and untapped areas like the Amazon region, denote an intriguing reservoir of biodiversity and chemically varied metabolites.
Daniela Valencia-Revelo, Esteban Charria-Girón, Katharina Schmidt, Silke Reinecke, Aida M. Vasco-Palacios, Theresia Stradal, Yasmina Marin-Felix, Nelson H. Caicedo-Ortega, Sherif S. Ebada   +8 more
doaj   +2 more sources

Cytochalasins from the Ash Endophytic Fungus Nemania diffusa DSM 116299 [PDF]

Molecules
The secondary metabolome of Nemania diffusa, isolated as an ash endophytic fungus, was analyzed in detail. From its cultures, a previously undescribed cytochalasin 1 was isolated using preparative HPLC, together with six known congeners: 18-dehydroxy ...
Özge Demir, Katharina Schmidt, Barbara Schulz, Theresia E. B. Stradal, Frank Surup   +4 more
doaj   +2 more sources

Novel inducible nitric oxide synthase-inhibiting cytochalasins from an oyster-derived fungus Westerdykella dispersa Ca4-13: structural insights and molecular docking analysis [PDF]

Botanical Studies
Background Marine-derived microorganisms are renowned for producing structurally diverse secondary metabolites with notable biological activities, serving as a promising reservoir for pharmaceutical development.
Shu-Jung Huang, Su-Jung Hsu, Shih-Wei Wang, Yi-Chien Liu, Cheng-Yan Jiang, George Hsiao, Tzong-Huei Lee   +6 more
doaj   +2 more sources

Metabolic Blockade-Based Genome Mining of Malbranchea circinata SDU050: Discovery of Diverse Secondary Metabolites [PDF]

Marine Drugs
Malbranchea circinata SDU050, a fungus derived from deep-sea sediment, is a prolific producer of diverse secondary metabolites. Genome sequencing revealed the presence of at least 69 biosynthetic gene clusters (BGCs), including 30 encoding type I ...
Hu Yang, Xiaowei Luo, Zhuo Shang, Kunlong Li, Jian Cai, Yingying Chen, Longchao Xin, Jianhua Ju   +7 more
doaj   +2 more sources

Harziachalasins A–G, polycyclic-fused cytochalasins from the endophytic fungus Trichoderma harzianum MLJ-4 with HIV latency reversal activity [PDF]

Natural Products and Bioprospecting
Seven new polycyclic-fused cytochalasins (CYTs), harziachalasins A–G (1–7), together with three known analogues (8–10) were isolated from the solid culture of the endophytic fungus Trichoderma harzianum MLJ-4, which was originally isolated from the ...
Yan-Jiang Zhang, Xian-Yuan Yang, Yi-Fan Fu, Qiong Liao, Jia-Qian Chen, Xian-An Chen, Dong Huang, Tao Yuan, Xin Chen, Sheng Yin, Gui-Hua Tang   +10 more
doaj   +2 more sources

Chemical structures, biological activities, and biosynthetic analysis of secondary metabolites of the Diatrypaceae family: A comprehensive review [PDF]

Mycology
The family Diatrypaceae is a less well-known group within the order Xylariales (Ascomycota). Initially, the focus on its metabolites was related to the pathogenicity of one of its members, Eutypa lata.
Shi-Jie Kang, Ling Zhao, Haiqiang Wang, Jin-Ming Gao, Jianzhao Qi   +4 more
doaj   +2 more sources