Results 51 to 60 of about 19,108 (270)

Forces and Structures of the Herpes Simplex Virus (HSV) Entry Mechanism. [PDF]

, 2015
This paper discusses physical and structural aspects of the mechanisms herpes simplex virus (HSV) uses for membrane fusion. Calculations show that herpes simplex virus glycoprotein D has such avidity for its receptors that it can hold the virion against ...
Clarke, Richard W
core   +3 more sources

Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae) Cytochalasins produced by Xylaria sp., an endophytic fungus from Piper aduncum

Química Nova, 2010
A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6).
Geraldo H. Silva, Camila M. de Oliveira, Helder L. Teles, Vanderlan da S. Bolzani, Angela R. Araujo, Ludwig H. Pfenning, Maria Claudia M. Young, Claudio M. Costa-Neto, Renato Haddad, Marcos N. Eberlin   +9 more
doaj   +1 more source

Actin-dependent cell elongation in teleost retinal rods: requirement for actin filament assembly. [PDF]

, 1981
Teleost retinal rods elongate when exposed to light. Elongation is mediated by a narrow necklike region called the myoid. In the cichlid Sarotherodon mossambicus, the rod inner segment (composed of the myoid with adjacent ellipsoid) increases in length ...
BURNSIDE, Beth, OConnor, P
core   +1 more source

Rho GTPases in mammalian spinal neural tube closure [PDF]

, 2018
Neural tube closure is an important morphogenetic event that involves dramatic reshaping of both neural and non-neural tissues. Rho GTPases are key cytoskeletal regulators involved in cell motility and in several developmental processes, and are thus ...
Copp, AJ, Escuin, S, Greene, ND, Rolo, A
core   +1 more source

Diagnostic fragmentation filtering for the discovery of new chaetoglobosins and cytochalasins.

Rapid Communications in Mass Spectrometry, 2018
RATIONALE Microbial natural products are often biosynthesized as classes of structurally related compounds that have similar tandem mass spectrometry (MS/MS) fragmentation patterns. Mining MS/MS datasets for precursor ions that share diagnostic or common
J. P. Walsh, J. Renaud, Shawn J. Hoogstra, D. R. McMullin, A. Ibrahim, C. Visagie, J. Tanney, K. Yeung, M. Sumarah   +8 more
semanticscholar   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Endothelial actin depolymerization mediates NADPH oxidase-superoxide production during flow reversal [PDF]

, 2014
Slow moving blood flow and changes in flow direction, e.g., negative wall shear stress, can cause increased superoxide (O2·−) production in vascular endothelial cells.
Choy, Jenny S., Kassab, Ghassan S., Lu, Xiao, Yang, Junrong, Zhang, Zhen-Du   +4 more
core   +1 more source

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, EarlyView.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, EarlyView.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut

BMC Complementary and Alternative Medicine, 2016
BackgroundThe continuous emergence of multidrug-resistant (MDR) bacteria drastically reduced the efficacy of our antibiotic armory and consequently, increased the frequency of therapeutic failure.
Jean-Bosco Jouda, Jean-De-Dieu Tamokou, C. Mbazoa, Clovis Douala-Meli, Prodipta Sarkar, P. Bag, J. Wandji   +6 more
semanticscholar   +1 more source