Results 21 to 30 of about 448,030 (290)

Radiothermometric Study of the Effect of Amino Acid Mutation on the Characteristics of the Enzymatic System

open access: yesDiagnostics, 2022
The radiothermometry (RTM) study of a cytochrome-containing system (CYP102 A1) has been conducted in order to demonstrate the applicability of RTM for monitoring changes in the functional activity of an enzyme in case of its point mutation. The study has
Yuri D. Ivanov   +9 more
doaj   +1 more source

The role of biotransformation processes in mediating interactions between psychotropic drugs and natural products

open access: yesJournal of Mind and Medical Sciences, 2020
Many patients are not aware that natural products such as fruit juices or plant infusions can cause significant interactions with several drugs, some of which can be dangerous, especially when the medical treatment is for neurological or psychiatric ...
Nicolae Bacinschi   +6 more
doaj   +1 more source

Redox-Regulation of α-Globin in Vascular Physiology

open access: yesAntioxidants, 2022
Interest in the structure, function, and evolutionary relations of circulating and intracellular globins dates back more than 60 years to the first determination of the three-dimensional structure of these proteins.
Laurent Kiger   +7 more
doaj   +1 more source

Electrostatic interaction of cytochrome c with cytochrome c1 and cytochrome oxidase.

open access: yesJournal of Biological Chemistry, 1981
The reactions of horse heart cytochrome c with succinate-cytochrome c reductase and cytochrome oxidase were studied as a function of ionic strength using both spectrophotometric and oxygen electrode assay techniques. The kinetic parameter Vmax/Km for both reactions decreased very rapidly as the ionic strength was increased, indicating that ...
Francis Millett, A J Ahmed, H T Smith
openaire   +3 more sources

Analysis of the Molecular Interactions between Cytochromes P450 3A4 and 1A2 and Aflatoxins: A Docking Study

open access: yesApplied Sciences, 2019
Mycotoxins known as aflatoxins (AF) are produced as a secondary metabolite by some species of Aspergillus fungi. They are considered carcinogenic, hepatotoxic, teratogenic, and mutagenic.
Isui Abril García-Montoya   +7 more
doaj   +1 more source

Bespoke Biomolecular Wires for Transmembrane Electron Transfer: Spontaneous Assembly of a Functionalized Multiheme Electron Conduit

open access: yesFrontiers in Microbiology, 2021
Shewanella oneidensis exchanges electrons between cellular metabolism and external redox partners in a process that attracts much attention for production of green electricity (microbial fuel cells) and chemicals (microbial electrosynthesis).
Samuel E. H. Piper   +8 more
doaj   +1 more source

Mitochondrial cytochrome-b, cytochrome-c and d-loop region based phylogenetic and diversity analysis in blackbuck (antilope cervicapra) [PDF]

open access: yesKafkas Universitesi Veteriner Fakültesi Dergisi, 2019
The present study was designed to find diversity analysis of Antilope cervicapra family in Pakistan. Fecal samples of Antilope cervicapra were collected from their different habitats of Pakistan. Fecal DNA was extracted and Polymerase Chain Reaction (PCR)
Ghulam ABBAS   +8 more
doaj   +1 more source

Effect of Salts on the Conformational Dynamics of the Cytochrome P450 OleP

open access: yesMolecules, 2023
Cytochrome P450 OleP catalytic activity is strongly influenced by its structural dynamic conformational behavior. Here, we combine equilibrium-binding experiments with all-atom molecular dynamics simulations to clarify how different environments affect ...
Maria Laura De Sciscio   +11 more
doaj   +1 more source

Genome-Wide Comparative Profiles of Triterpenoid Biosynthesis Genes in Ginseng and Pseudo Ginseng Medicinal Plants

open access: yesLife, 2023
Saponin-rich medicinal plants, particularly ginseng and Pseudo ginseng, are valuable in traditional medical practice due to the presence of different saponins.
Jing Lu
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

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