Results 31 to 40 of about 630,553 (340)

Pitavastatin: focus on safety and drug interactions

КардиоСоматика, 2021
Pitavastatin is a drug from the group of HMG-CoA reductase inhibitors, which has good lipid-lowering efficacy and has no significant effect on the risk of diabetes mellitus.
Larisa O. Minushkina, Dmitry A. Zateyshchikov   +1 more
doaj   +1 more source

Bespoke Biomolecular Wires for Transmembrane Electron Transfer: Spontaneous Assembly of a Functionalized Multiheme Electron Conduit

Frontiers in Microbiology, 2021
Shewanella oneidensis exchanges electrons between cellular metabolism and external redox partners in a process that attracts much attention for production of green electricity (microbial fuel cells) and chemicals (microbial electrosynthesis).
Samuel E. H. Piper, Marcus J. Edwards, Jessica H. van Wonderen, Carla Casadevall, Anne Martel, Lars J. C. Jeuken, Erwin Reisner, Thomas A. Clarke, Julea N. Butt   +8 more
doaj   +1 more source

Murburn concept: a paradigm shift in cellular metabolism and physiology

Biomolecular Concepts, 2020
Two decades of evidence-based exploratory pursuits in heme-flavin enzymology led to the formulation of a new biological electron/moiety transfer paradigm, called murburn concept.
Manoj Kelath Murali
doaj   +1 more source

Bax directly induces release of cytochrome c from isolated mitochondria.

Proceedings of the National Academy of Sciences of the United States of America, 1998
Bax is a pro-apoptotic member of the Bcl-2 protein family that resides in the outer mitochondrial membrane. It is controversial whether Bax promotes cell death directly through its putative function as a channel protein versus indirectly by inhibiting ...
J. Jürgensmeier, Z. Xie, Q. Deveraux, L. Ellerby, D. Bredesen, John Calvin Reed   +5 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Iron Corrosion via Direct Metal-Microbe Electron Transfer

mBio, 2019
The concept that anaerobic microorganisms can directly accept electrons from Fe(0) has been controversial because direct metal-microbe electron transfer has previously only been indirectly inferred.
Hai-Yan Tang, Dawn E. Holmes, Toshiyuki Ueki, Paola A. Palacios, Derek R. Lovley   +4 more
doaj   +1 more source

Cytochrome c binding affects the conformation of cytochrome a in cytochrome c oxidase.

Journal of Biological Chemistry, 1992
Second derivative absorption spectroscopy has been used to assess the effects of complex formation between cytochrome c and cytochrome c oxidase on the conformation of the cytochrome a cofactor. When ferrocytochrome c is complexed to the cyanide-inhibited reduced or mixed valence enzyme, the conformation of ferrocytochrome a is affected.
D Sherman, S R Lynch, R A Copeland
openaire   +3 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Widespread Distribution and Functional Specificity of the Copper Importer CcoA: Distinct Cu Uptake Routes for Bacterial Cytochrome c Oxidases

mBio, 2018
Cytochrome c oxidases are members of the heme-copper oxidase superfamily. These enzymes have different subunits, cofactors, and primary electron acceptors, yet they all contain identical heme-copper (CuB) binuclear centers within their catalytic subunits.
Bahia Khalfaoui-Hassani, Hongjiang Wu, Crysten E. Blaby-Haas, Yang Zhang, Federica Sandri, Andreia F. Verissimo, Hans-Georg Koch, Fevzi Daldal   +7 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source