Results 161 to 170 of about 13,151,257 (336)

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

First Complete Cytochrome B Sequences and Molecular Taxonomy of Bat Species from Sri Lanka. [PDF]

Animals (Basel), 2022
Perera T, Schwarz F, Muzeniek T, Siriwardana S, Becker-Ziaja B, Perera IC, Handunnetti S, Weerasena J, Premawansa G, Premawansa S, Nitsche A, Yapa W, Kohl C.   +12 more
europepmc   +1 more source

Effects of Eleutheroside B and Eleutheroside E on activity of cytochrome P450 in rat liver microsomes [PDF]

, 2014
Sixun Guo, Yan Liu, Zhiping Lin, Sheng Tai, Shuo Yin, Gaofeng Liu   +5 more
openalex   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Taxonomy of Mitochondrial Cytochrome B Proteins of the Same Amino Acid Sequence Length. [PDF]

ScientificWorldJournal, 2021
Zamyatnin AA, Belozerskaya TA, Zamyatnin AA.   +2 more
europepmc   +1 more source

Recessive congenital methaemoglobinaemia: functional characterization of the novel D239G mutation in the NADH‐binding lobe of cytochrome b₅ reductase [PDF]

, 2005
Melanie J. Percy, Louis J. Crowley, Christopher Davis, Mary Frances McMullin, G. Savage, Joanne Hughes, Corrina McMahon, R J Quinn, Owen Smith, Michael Barber, Terence R.J. Lappin   +10 more
openalex   +1 more source

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

Analysis of mitochondrial DNA cytochrome-b (CYB) and ATPase-6 gene mutations in COVID-19 patients. [PDF]

J Med Virol, 2022
Dirican E, Savrun ŞT, Aydın İE, Gülbay G, Karaman Ü.   +4 more
europepmc   +1 more source

Study of Genetic Marker of Cuscuses (Marsupialia: Phalangeridae) from Maluku and Papua Based on Cytochrome b Gene Sequences [PDF]

, 2016
Rony Marsyal Kunda, Niken Satuti Nur Handayani, Hery Wijayanto, Rini Widayanti   +3 more
openalex   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source