Results 11 to 20 of about 365,101 (261)
Structural Insights into Mechanisms Underlying Mitochondrial and Bacterial Cytochrome c Synthases [PDF]
BiomoleculesMitochondrial holocytochrome c synthase (HCCS) is an essential protein in assembling cytochrome c (cyt c) of the electron transport system. HCCS binds heme and covalently attaches the two vinyls of heme to two cysteine thiols of the cyt c CXXCH motif ...
Pema L. Childs +6 more
doaj +2 more sources
Cytochrome c Negatively Regulates NLRP3 Inflammasomes. [PDF]
PLoS ONE, 2016 The release of cytochrome c from the inner mitochondrial membrane, where it is anchored by caridolipin, triggers the formation of the Apaf-1 apoptosome. Cardiolipin also interacts with NLRP3 recruiting NLRP3 to mitochondria and facilitating inflammasome ...
Chong-Shan Shi, John H Kehrl
doaj +1 more source
Interspecies Variation in the Functional Consequences of Mutation of Cytochrome c. [PDF]
PLoS ONE, 2015 The naturally occurring human cytochrome c variant (G41S) is associated with a mild autosomal dominant thrombocytopenia (Thrombocytopenia Cargeeg) caused by dysregulation of platelet production.
Tracy M Josephs +4 more
doaj +1 more source
New insight into the mechanism of mitochondrial cytochrome c function. [PDF]
PLoS ONE, 2017 We investigate functional role of the P76GTKMIFA83 fragment of the primary structure of cytochrome c. Based on the data obtained by the analysis of informational structure (ANIS), we propose a model of functioning of cytochrome c. According to this model,
Rita V Chertkova +9 more
doaj +1 more source
Lysine-PEGylated Cytochrome C with Enhanced Shelf-Life Stability
Biosensors, 2022 Cytochrome c (Cyt-c), a small mitochondrial electron transport heme protein, has been employed in bioelectrochemical and therapeutic applications. However, its potential as both a biosensor and anticancer drug is significantly impaired due to poor long ...
João H. P. M. Santos +6 more
doaj +1 more source
Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase
Cells, 2021 Cytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears of particular importance, since it evolved early during evolution and is still ...
Rabia Ramzan +2 more
doaj +1 more source
In-silico assessment of protein-protein electron transfer. a case study: cytochrome c peroxidase--cytochrome c. [PDF]
PLoS Computational Biology, 2013 The fast development of software and hardware is notably helping in closing the gap between macroscopic and microscopic data. Using a novel theoretical strategy combining molecular dynamics simulations, conformational clustering, ab-initio quantum ...
Frank H Wallrapp +2 more
doaj +1 more source
Crystallographic studies of cytochrome c and cytochrome c oxidase [PDF]
The Journal of Biochemistry, 2021 I started on crystallographic studies of cytochrome c (Cyt.c) in the later 1960s at Institute for Protein Research, Osaka University. The institute successfully built the structural model of ferro-Cyt.c by the multiple heavy atom replacement method in the early 1970s.
openaire +2 more sources
Mitochondrial Encephalopathy and Cytochrome C
Pediatric Neurology Briefs, 1997 Benefits from treatment of mitochondrial encephalomyopathy (MEM) with cytochrome C (6.25 mg) and vitamins Bl (25 mg) and B2 (12.5 mg), in daily injections, are reported from Osaka University Medical School and other centers in Japan.
J Gordon Millichap
doaj +1 more source
Electron transfer interactome of cytochrome C.
PLoS Computational Biology, 2012 Lying at the heart of many vital cellular processes such as photosynthesis and respiration, biological electron transfer (ET) is mediated by transient interactions among proteins that recognize multiple binding partners.
Alexander N Volkov, Nico A J van Nuland
doaj +1 more source