Results 91 to 100 of about 19,855,151 (220)

New insights into the cytochrome c biogenesis in Rhodobacter capsulatus

, 2001
C-type cytochromes are electron carrier proteins that contain a covalently bound heme prosthetic group. The post-translational processes that bring about heme binding to the cytochrome polypeptide are collectively referred to as cytochrome c biogenesis ...
Deshmukh, Meenal
core  

Morphofunctional and Biochemical Approaches for Studying Mitochondrial Changes during Myoblasts Differentiation

Journal of Aging Research, 2011
This study describes mitochondrial behaviour during the C2C12 myoblast differentiation program and proposes a proteomic approach to mitochondria integrated with classical morphofunctional and biochemical analyses.
Elena Barbieri, Michela Battistelli, Lucia Casadei, Luciana Vallorani, Giovanni Piccoli, Michele Guescini, Anna Maria Gioacchini, Emanuela Polidori, Sabrina Zeppa, Paola Ceccaroli, Laura Stocchi, Vilberto Stocchi, Elisabetta Falcieri   +12 more
doaj   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

MR-1S Interacts with PET100 and PET117 in Module-Based Assembly of Human Cytochrome c Oxidase

Cell Reports, 2017
The biogenesis of human cytochrome c oxidase (COX) is an intricate process in which three mitochondrial DNA (mtDNA)-encoded core subunits are assembled in a coordinated way with at least 11 nucleus-encoded subunits.
Sara Vidoni, Michael E. Harbour, Sergio Guerrero-Castillo, Alba Signes, Shujing Ding, Ian M. Fearnley, Robert W. Taylor, Valeria Tiranti, Susanne Arnold, Erika Fernandez-Vizarra, Massimo Zeviani   +10 more
doaj   +1 more source

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

iNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang, Rongyu Guo, Xiaojun Feng, Liqin Tang   +3 more
wiley   +1 more source

Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis

EMBO Molecular Medicine, 2018
The mTOR inhibitor rapamycin ameliorates the clinical and biochemical phenotype of mouse, worm, and cellular models of mitochondrial disease, via an unclear mechanism.
Gabriele Civiletto, Sukru Anil Dogan, Raffaele Cerutti, Gigliola Fagiolari, Maurizio Moggio, Costanza Lamperti, Cristiane Benincá, Carlo Viscomi, Massimo Zeviani   +8 more
doaj   +1 more source

Photosynthetic electron transfer and c-type cytochrome biogenesis in the bacterium Rhodobacter capsulatus

, 1994
The bacterium Rhodobacter capsulatus is able to grow photosynthetically (Ps$\sp+$) in the absence of the soluble electron carrier cytochrome (cyt) $c\sb2$ (Daldal et al. 1986 PNAS USA. 83, 2012-2016).
Jenney, Francis Edward
core  

Mss51 and Ssc1 Facilitate Translational Regulation of Cytochrome c Oxidase Biogenesis

, 2010
The intricate biogenesis of multimeric organellar enzymes of dual genetic origin entails several levels of regulation. In Saccharomyces cerevisiae , mitochondrial cytochrome c oxidase (COX) assembly is regulated translationally.
Horn, Darryl, Barrientos, Antoni, Fontanesi, Flavia, Soto, Iliana C   +3 more
core   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

Cytochrome c oxidase biogenesis in a patient with a mutation in COX10 gene

Annals of Neurology, 2004
AbstractWe report a cytochrome c oxidase (COX)–deficient patient, clinically affected with Leigh‐like disease, with a homozygous mutation in the COX10 start codon. Two‐dimensional gel electrophoresis showed a decrease of fully assembled COX without the accumulation of partially assembled COX subcomplexes.
Coenen, M.J.H., Heuvel, L.P.W.J. van den, Ugalde, C., Brinke, M. ten, Nijtmans, L.G.J., Trijbels, J.M.F., Beblo, S., Maier, E.M., Muntau, A.C., Smeitink, J.A.M.   +9 more
openaire   +3 more sources