Results 101 to 110 of about 2,436,389 (378)

Irisin protects cardiomyocytes against hypoxia/reoxygenation injury via attenuating AMPK mediated endoplasmic reticulum stress

Scientific Reports, 2022
Endoplasmic reticulum (ER) stress plays a central role in myocardial ischemia/reperfusion (I/R) injury. Irisin has been reported to have protective properties in ischemia disease.
Rongchuan Yue, Mingming Lv, Meide Lan, Zaiyong Zheng, Xin Tan, Xuemei Zhao, Yulong Zhang, Jun Pu, Lei Xu, Houxiang Hu   +9 more
doaj   +1 more source

Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV [PDF]

, 2019
The proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense debate, since altering it leads to cell aging and other related pathologies.
Díaz Moreno, Irene, Díaz Quintana, Antonio Jesús, Guerra Castellano, Alejandra, Pérez Mejías, Gonzalo, Rosa Acosta, Miguel Ángel de la   +4 more
core   +1 more source

The Conserved Mitochondrial Twin Cx9C Protein Cmc2 Is a Cmc1 Homologue Essential for Cytochrome c Oxidase Biogenesis*

Journal of Biological Chemistry, 2010
Mitochondrial copper metabolism and delivery to cytochrome c oxidase and mitochondrially localized CuZn-superoxide dismutase (Sod1) requires a growing number of intermembrane space proteins containing a twin Cx9C motif.
D. Horn, Wen Zhou, E. Trevisson, H. Al-Ali, T. Harris, L. Salviati, A. Barrientos   +6 more
semanticscholar   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Nori- and Sea Spaghetti- but not Wakame-restructured pork decrease the hypercholesterolemic and liver proapototic short-term effects of high-dietary cholesterol consumption

Nutrición Hospitalaria, 2013
Restructured pork (RP) enriched in Seaweeds are potential functional foods. The antiapoptotic and hypocholesterolemic effects of consuming cholesterol enriched diets containing Wakame-RP (CW), Nori-RP (CN) and Sea Spaghetti (CS) were tested in a 1-wk ...
Adriana R. Schultz Moreira, Juana Benedi, Sara Bastida, Isabel Sánchez-Reus, Francisco J. Sánchez-Muniz   +4 more
doaj   +1 more source

Oriented immobilization and electron transfer to the cytochrome c oxidase

, 2011
Direct electron transfer to cytochrome c oxidase (CcO) is investigated as a function of packing density of the surface layer. This is varied by the surface concentration of chelator molecules when the enzyme is immobilized on the electrode using the his ...
C. Nowak, D. Schach, J. Gebert, Marc Grosserueschkamp, R. Gennis, S. Ferguson-Miller, W. Knoll, D. Walz, R. Naumann   +8 more
semanticscholar   +1 more source

Gentamicin‐Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections

Advanced Healthcare Materials, EarlyView.
A bone substitute with gentamicin physically precipitated onto the surface of carbonate apatite exhibits prompt drug release, high bactericidal activity, and osteogenic capacity. Efficient antibacterial activity mitigates early postoperative neutrophil accumulation, the status of which may serve as a potential parameter for evaluating the antibacterial
Linghao Xiao, Gabriela Laranjeira Abe, Jun‐Ichi Sasaki, Haruaki Kitagawa, Ririko Tsuboi, Tomoki Kohno, Satoshi Imazato   +6 more
wiley   +1 more source

Molecular study of globally threatened turtle species (families Trionychidae and Geoemydidae) of Uttarakhand and their relationship with other Indian populations: A wildlife forensic and conservation genetic approach

Forensic Science International: Reports, 2019
A DNA reference library was generated, and a phylogenetic assessment of 11 turtle species (in nine genera and two families) from Uttarakhand was carried out.
Ankita Rajpoot, Archana Bahuguna, Ved Prakash Kumar   +2 more
doaj   +1 more source

Mapping the Cytochrome C Folding Landscape [PDF]

, 2003
The solution to the riddle of how a protein folds is encoded in the conformational energy landscape for the constituent polypeptide. Employing fluorescence energy transfer kinetics, we have mapped the S.
Lyubovitsky, Julia Gennadievna
core   +1 more source

Assignment of the CO-sensitive carboxyl group in mitochondrial forms of cytochrome c oxidase using yeast mutants

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012
Point mutations of E243D and I67N were introduced into subunit I of a 6histidine-tagged (6H-WT) form of yeast Saccharomyces cerevisiae mitochondrial cytochrome c oxidase. The two mutants (6H-E243D(I) and 6H-I67N(I)) were purified and showed ≈50 and 10% of the 6H-WT turnover number. Light-induced CO photolysis FTIR difference spectra of the 6H-WT showed
Maréchal, A, Meunier, B, Rich, PR
openaire   +3 more sources