Results 191 to 200 of about 468,875 (312)

Zinc Overload in Microvessels Contributes to Blood-Brain Barrier Disruption by Activating the JAK2 Pathway After Cerebral Ischemia/Reperfusion. [PDF]

CNS Neurosci Ther
Guo Z, Shi W, Chen X, Yuan S, Ji X, Qi Z.   +5 more
europepmc   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Cytochrome P450 gene family: cross-pathway functional conservation, novel catalytic reactions, and synthetic biology-driven applications in plant secondary metabolism. [PDF]

Front Plant Sci
Chen L, Zhao Y, He S, Lei J, Li H, Liu Z, Zhang L, Yang L, Deng K, Wan R, Xu D.   +10 more
europepmc   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery. [PDF]

Proc Natl Acad Sci U S A
Davey SD, Forde-Thomas JE, Hulme BJ, Lees K, Costain AH, Evans M, Rinaldi G, Frame L, Stojanovski L, Simeons FRC, Tavendale A, MacLeod AK, Pichon R, Lee YH, Polak O, Chalmers IW, Dankwa B, Odhiambo BK, Guimaraes VH, Hegarty M, Swain MT, Aubrey W, Caldwell N, MacDonald AS, Gilbert IH, Baragaña B, Read KD, Hoffmann KF.   +27 more
europepmc   +1 more source

Biosynthesis and assembly of mitochondrial proteins [PDF]

, 1983
A Scarpa, A Tzagoloff, AP Autor, AS Lewin, B Hennig, BC Pressman, C Côte, C Zwizinski, D Lloyd, DD Sabatini, DI Meyer, DI Meyer, DL Stigall, E Schmelzer, G Blobel, G Hallermayer, G Kreibich, G Macino, G Palade, G Schatz, G Schatz, GC Shore, H Freitag, H Freitag, H Korb, H Weiss, HW Heldt, J Subik, JG Conboy, JG Conboy, K Mihara, K Mihara, K Yamauchi, K Yamauchi, LAM Hensgens, M Klingenberg, M Mori, M Mori, M Schleyer, M Teintze, M-L Maccecchini, M-L Maccecchini, MA Harmey, N Nabi, N Nabi, N Nelson, N-H Chua, N-H Chua, P Böhni, P Sonderegger, P Sonderegger, P Walter, P Walter, P Walter, P Walter, PC Heinrich, PC Mcada, R Michel, R Sakakibara, R Zimmermann, R Zimmermann, R Zimmermann, R Zimmermann, RC Jackson, RN Dubois, S Matsuura, S Miura, SM Gasser, SN Graven, T Morita, W Neupert, W Sebald, W Wickner, Y Okada, Y Raymond, Y Raymond   +75 more
core   +1 more source

Hepatotoxicity of Nonesterified Fatty Acids to Dairy Cows: Pathophysiological Mechanisms and Prospective Solutions

Animal Research and One Health, EarlyView.
Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao, Yuan Tian, Dan Li, Lei Tian, Hang Yu, Ziling Liu, Xin Gao, Yanqiong Wen, Fachun Wan, Zuo Wang, Weijun Shen, Xinwei Li, Lei Liu   +12 more
wiley   +1 more source

Comparison of cytochrome P450 activity and mRNA expression in canine vs. human hepatocytes after acetaminophen, diclofenac, or valproic acid exposure. [PDF]

J Vet Sci
Kang JR, Lee J, Suh HN.
europepmc   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source