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Cytochrome-C Oxidase Deficiency
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2020 The severity of cytochrome c oxidase deficiency varies widely among affected individuals, even among those in the same family. People who are mildly affected tend to have muscle weakness (myopathy) and poor muscle tone (hypotonia) with no other related ...
M. Brischigliaro, M. Zeviani
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Serial femtosecond crystallography structure of cytochrome c oxidase at room temperature
Scientific Reports, 2017 Cytochrome c oxidase catalyses the reduction of molecular oxygen to water while the energy released in this process is used to pump protons across a biological membrane.
Rebecka Andersson +15 more
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Copper-Induced Enhancement of Glioblastoma Tumorigenicity via Cytochrome C Oxidase [PDF]
AntioxidantsCopper is an essential trace element, yet chronic copper exposure can lead to toxicity in humans, and high levels of copper have been found in the blood or tumors of patients with various forms of cancer and may affect cancer severity and response to ...
Claudia R. Oliva +3 more
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Crystallographic studies of cytochrome c and cytochrome c oxidase. [PDF]
J Biochem, 2022 I started on crystallographic studies of cytochrome c (Cyt.c) in the later 1960s at Institute for Protein Research, Osaka University. The institute successfully built the structural model of ferro-Cyt.c by the multiple heavy atom replacement method in the early 1970s.
Tsukihara T.
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Direct regulation of cytochrome c oxidase by calcium ions. [PDF]
PLoS ONE, 2013 Cytochrome c oxidase from bovine heart binds Ca(2+) reversibly at a specific Cation Binding Site located near the outer face of the mitochondrial membrane.
Tatiana Vygodina +2 more
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Evolution of a biological thermocouple by adaptation of cytochrome c oxidase in a subterrestrial metazoan, Halicephalobus mephisto [PDF]
Communications BiologyIn this study, we report a biological temperature-sensing electrical regulator in the cytochrome c oxidase of the Devil Worm, Halicephalobus mephisto.
Megan N. Guerin +10 more
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Coordination of metal center biogenesis in human cytochrome c oxidase [PDF]
Nature Communications, 2022 Mitochondrial cytochrome c oxidase is a heme aa3-copper oxygen reductase. Here, authors report that metal center-specific metallochaperones form dynamic assemblies to control heme a biosynthesis and coordinate copper transfer to the copper sites.
Eva Nývltová +4 more
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Cytochrome c Oxidase Inhibition by ATP Decreases Mitochondrial ROS Production [PDF]
Cells, 2022 This study addresses the eventual consequence of cytochrome c oxidase (CytOx) inhibition by ATP at high ATP/ADP ratio in isolated rat heart mitochondria. Earlier, it has been demonstrated that the mechanism of allosteric ATP inhibition of CytOx is one of
Rabia Ramzan +6 more
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Coupling in cytochrome c oxidase [PDF]
Proceedings of the National Academy of Sciences, 1977 Cytochrome c oxidase (ferrocytochrome c : oxygen oxidoreductase; EC 1.9.3.1) can be resolved into an electron transfer complex (ETC) and an ionophore transfer complex (ITC). Coupling requires an interaction between the moving electron in the ETC and a moving, positively charged ionophore ...
Ralph J. Kessler +4 more
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Cytochrome c Oxidase Components
Journal of Biological Chemistry, 1963 Shigeo Horie, Martin Morrison
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