Results 1 to 10 of about 243,821 (350)
Copper-Induced Enhancement of Glioblastoma Tumorigenicity via Cytochrome C Oxidase [PDF]
AntioxidantsCopper is an essential trace element, yet chronic copper exposure can lead to toxicity in humans, and high levels of copper have been found in the blood or tumors of patients with various forms of cancer and may affect cancer severity and response to ...
Claudia R. Oliva +3 more
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Evolution of a biological thermocouple by adaptation of cytochrome c oxidase in a subterrestrial metazoan, Halicephalobus mephisto [PDF]
Communications BiologyIn this study, we report a biological temperature-sensing electrical regulator in the cytochrome c oxidase of the Devil Worm, Halicephalobus mephisto.
Megan N. Guerin +10 more
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Coordination of metal center biogenesis in human cytochrome c oxidase [PDF]
Nature Communications, 2022 Mitochondrial cytochrome c oxidase is a heme aa3-copper oxygen reductase. Here, authors report that metal center-specific metallochaperones form dynamic assemblies to control heme a biosynthesis and coordinate copper transfer to the copper sites.
Eva Nývltová +4 more
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Coupling in cytochrome c oxidase [PDF]
Proceedings of the National Academy of Sciences, 1977 Cytochrome c oxidase (ferrocytochrome c : oxygen oxidoreductase; EC 1.9.3.1) can be resolved into an electron transfer complex (ETC) and an ionophore transfer complex (ITC). Coupling requires an interaction between the moving electron in the ETC and a moving, positively charged ionophore ...
Ralph J. Kessler +4 more
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Cytochrome c Oxidase Components
Journal of Biological Chemistry, 1963 Shigeo Horie, Martin Morrison
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Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase
Cells, 2021 Cytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears of particular importance, since it evolved early during evolution and is still ...
Rabia Ramzan +2 more
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Cytochrome c oxidase deficiency
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2021 Cytochrome c oxidase (COX) deficiency is characterized by a high degree of genetic and phenotypic heterogeneity, partly reflecting the extreme structural complexity, multiple post-translational modification, variable, tissue-specific composition, and the high number of and intricate connections among the assembly factors of this enzyme.
Brischigliaro M., Zeviani M.
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Nature Communications, 2021 Cytochrome c oxidase is a fundamental enzyme of life and its mechanism is not fully understood yet. Here, the authors present four cryo-EM structures of different intermediate states, which suggest an alternative cytochrome c oxidase reaction cycle.
F. Kolbe +5 more
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Cytochrome c Oxidase Deficiency [PDF]
Pediatric Research, 1990 Cytochrome c oxidase (COX) is a complex enzyme composed of 13 subunits, three of which are encoded by the mitochondrial DNA (mtDNA). The other 10 subunits are encoded by the nuclear DNA, synthesized in the cytoplasm, and transported into the mitochondria.
Dlmauro S. +9 more
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Rcf1 Modulates Cytochrome c Oxidase Activity Especially Under Energy-Demanding Conditions
Frontiers in Physiology, 2020 The mitochondrial respiratory chain is assembled into supercomplexes. Previously, two respiratory supercomplex-associated proteins, Rcf1 and Rcf2, were identified in Saccharomyces cerevisiae, which were initially suggested to mediate supercomplex ...
Hannah Dawitz +5 more
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