Results 151 to 160 of about 541,087 (354)

COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase

open access: yesCell Reports, 2019
Summary: In eukaryotes, cellular respiration is driven by mitochondrial cytochrome c oxidase (CcO), an enzyme complex that requires copper cofactors for its catalytic activity.
Shivatheja Soma   +12 more
doaj  

Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase

open access: yesGenome Biology, 2012
Orthology is a central tenet of comparative genomics and ortholog identification is instrumental to protein function prediction. Major advances have been made to determine orthology relations among a set of homologous proteins.
R. Szklarczyk   +10 more
semanticscholar   +1 more source

Cuproplasia and cuproptosis, two sides of the coin

open access: yesCancer Communications, EarlyView.
Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory ...
Kaizhong Lu   +4 more
wiley   +1 more source

Evaluation of the Pharmacokinetic Drug Interaction of Capmatinib With Itraconazole and Rifampicin and Potential Impact on Renal Transporters in Healthy Subjects

open access: yesThe Journal of Clinical Pharmacology, Volume 63, Issue 2, Page 228-238, February 2023., 2023
Abstract Capmatinib is a highly specific, potent, and selective mesenchymal–epithelial transition factor inhibitor predominantly eliminated by cytochrome P450 (CYP) 3A4 and aldehyde oxidase. Here, we investigated the effects of a strong CYP3A inhibitor (itraconazole) and a strong CYP3A inducer (rifampicin) on single‐dose pharmacokinetics of capmatinib.
Xiaoming Cui   +6 more
wiley   +1 more source

Molecular Identification of Fish Larvae from East Plawangan of Segara Anakan, Cilacap, Central Java, Indonesia

open access: yesBiosaintifika: Journal of Biology & Biology Education, 2017
Correct identification of fish larvae from East Plawangan is very difficult to be done due to undefined of their morphology, while correct name is an important information for management of that area as spawning and nersery ground.
Agus Nuryanto   +2 more
doaj   +1 more source

Understanding the behavioural difference of PPCA among its homologs in C7 family towards recognition of DXCA [PDF]

open access: yesarXiv, 2015
Among all the proteins of Periplasmic C type cytochrome A (PPCA) family obtained from cytochrome C7 found in Geobacter sulfurreducens, PPCA protein can interact with Deoxycholate (DXCA), while its other homologs do not, as observed from the crystal structures.
arxiv  

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

open access: yesCancer Communications, EarlyView.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan   +13 more
wiley   +1 more source

Identification of Hypoderma actaeon (Diptera: Oestridae) in red deer (Cervus elaphus) from northern Spain: Microscopy study and molecular analysis

open access: yesMicroscopy Research and Technique, Volume 86, Issue 1, Page 3-11, January 2023., 2023
Third‐instar Hypoderma actaeon. Abstract Hypoderma spp. larvae were observed subcutaneously in the dorsal and lumbar regions of red deer (Cervus elaphus) hunted in the province of León (northwestern Spain) causing a myiasis. They were removed and initially classified by their size, shape, color, and location under the skin into the three larval stages ...
Sara González   +4 more
wiley   +1 more source

Carbon Nanotubes as Intracellular Protein Transporters: Generality and Biological Functionality [PDF]

open access: yesarXiv, 2005
Various proteins adsorb spontaneously on the sidewalls of acid-oxidized single-walled carbon nanotubes. This simple non-specific binding scheme can be used to afford non-covalent protein-nanotube conjugates. The proteins are found to be readily transported inside various mammalian cells with nanotubes acting as the transporter via the endocytosis ...
arxiv  

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