Results 31 to 40 of about 541,087 (354)

Oxygen Activation and Energy Conservation by Cytochrome c Oxidase

Chemical Reviews, 2018
This review focuses on the type A cytochrome c oxidases (CcO), which are found in all mitochondria and also in several aerobic bacteria. CcO catalyzes the respiratory reduction of dioxygen (O2) to water by an intriguing mechanism, the details of which ...
M. Wikström, K. Krab, Vivek Sharma
semanticscholar   +1 more source

Mechanical ventilation preserves diaphragm mitochondrial function in a rat sepsis model

Intensive Care Medicine Experimental, 2021
Background To describe the effect of mechanical ventilation on diaphragm mitochondrial oxygen consumption, ATP production, reactive oxygen species (ROS) generation, and cytochrome c oxidase activity and content, and their relationship to diaphragm ...
P. Eyenga, D. Roussel, B. Rey, P. Ndille, L. Teulier, F. Eyenga, C. Romestaing, J. Morel, V. Gueguen-Chaignon, S-S. Sheu   +9 more
doaj   +1 more source

The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants

International Journal of Molecular Sciences, 2018
Mitochondrial respiration is an energy producing process that involves the coordinated action of several protein complexes embedded in the inner membrane to finally produce ATP.
Natanael Mansilla, S. Racca, D. E. Gras, D. Gonzalez, E. Welchen   +4 more
semanticscholar   +1 more source

Kinetics of proton pumping in cytochrome c oxidase [PDF]

J. Chem. Phys. 130, 235105 (2009), 2008
We propose a simple model of cytochrome c oxidase, including four redox centers and four protonable sites, to study the time evolution of electrostatically coupled electron and proton transfers initiated by the injection of a single electron into the enzyme.
arxiv   +1 more source

New insight into the mechanism of mitochondrial cytochrome c function. [PDF]

PLoS ONE, 2017
We investigate functional role of the P76GTKMIFA83 fragment of the primary structure of cytochrome c. Based on the data obtained by the analysis of informational structure (ANIS), we propose a model of functioning of cytochrome c. According to this model,
Rita V Chertkova, Nadezda A Brazhe, Tatiana V Bryantseva, Alexey N Nekrasov, Dmitry A Dolgikh, Alexander I Yusipovich, Olga Sosnovtseva, Georgy V Maksimov, Andrei B Rubin, Mikhail P Kirpichnikov   +9 more
doaj   +1 more source

Portosystemic hepatic encephalopathy model shows reversal learning impairment and dysfunction of neural activity in the prefrontal cortex and regions involved in motivated behavior [PDF]

Journal of Clinical Neuroscience (2011)18(5):690-4, 2011
Hepatic encephalopathy is a neurological complication that affects attention and memory. Experimental animal models have been used to study hepatic Encephalopathy, the most frequent being the portacaval shunt. In order to determine learning impairment and brain functional alterations in this model, we assessed reversal learning and neural metabolic ...
arxiv   +1 more source

From Jöbsis to the present day: a review of clinical near-infrared spectroscopy measurements of cerebral cytochrome-c-oxidase

Journal of Biomedical Optics, 2016
. Near-infrared spectroscopy (NIRS) measurements of cytochrome-c-oxidase (CCO) have the potential to yield crucial information about cerebral metabolism at the patient bedside.
Gemma Bale, C. Elwell, I. Tachtsidis
semanticscholar   +1 more source

Thermodynamic Volume Cycles for Electron Transfer in the Cytochrome c Oxidase and for the Binding of Cytochrome c to Cytochrome c Oxidase [PDF]

Biophysical Journal, 1998
Dilatometry is a sensitive technique for measuring volume changes occurring during a chemical reaction. We applied it to the reduction-oxidation cycle of cytochrome c oxidase, and to the binding of cytochrome c to the oxidase. We measured the volume changes that occur during the interconversion of oxidase intermediates.
Gaston Hui Bon Hoa, Isabelle Rajotte, Peter C. Kahn, Mary Judith Kornblatt, Jack A. Kornblatt   +4 more
openaire   +3 more sources

How germline genes promote malignancy in cancer cells

BioEssays, Volume 45, Issue 1, January 2023., 2023
We hypothesize that activation of a “germline program” promotes oncogenesis. Expression of otherwise germline specific genes may result in pseudomeiotic activity, thereby promoting oncogenesis through genomic instability. Other processes that are differentially regulated in the germline, such as migration and epigenetic – and metabolic plasticity, may ...
Jan Willem Bruggeman, Jan Koster, Ans M. M. van Pelt, Dave Speijer, Geert Hamer   +4 more
wiley   +1 more source

Amyloid-β peptide binds to cytochrome C oxidase subunit 1.

PLoS ONE, 2012
Extracellular and intraneuronal accumulation of amyloid-beta aggregates has been demonstrated to be involved in the pathogenesis of Alzheimer's disease (AD).
Luis Fernando Hernandez-Zimbron, Jose Luna-Muñoz, Raul Mena, Ricardo Vazquez-Ramirez, Carlos Kubli-Garfias, David H Cribbs, Karen Manoutcharian, Goar Gevorkian   +7 more
doaj   +1 more source