Susceptibility to endometrial cancer: influence of allelism at p53, glutathione S-transferase (GSTM1 and GSTT1) and cytochrome P-450 (CYP1A1) loci [PDF]
British Journal of Cancer, 1997 A case-control study was designed to identify associations between polymorphisms at p53, cytochrome P-450 (CYP1A1) and glutathione-S-transferases and endometrial cancer susceptibility. Among all polymorphisms analysed, an insertional variant in p53 (P53PIN3) and two polymorphisms in the 3'-end and exon 7 of CYP1A1 showed significant association with ...
M, Esteller +4 more
openaire +4 more sources
A Modeling Investigation of the CYP1A Drug Interactions of Riluzole [PDF]
Clinical and Translational ScienceCytochrome‐P‐450 (CYP)1A2 has been considered the major enzyme metabolizing riluzole since its approval. However, the inhibitor that was used in the original experiments, α‐naphthoflavone, is also a potent inhibitor of CYP1A1.
Paul Malik +4 more
doaj +2 more sources
Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-Ultraviolet A (PUVA) sensitivity [PDF]
, 2013 Background: There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochemotherapy, used to treat skin diseases including psoriasis.
Deeni, Yusuf Y. +4 more
core +15 more sources
Zanco Journal of Pure and Applied Sciences, 2023 Acute Myeloid Leukemia (AML) and Chronic Myeloid Leukemia (CML) are life-threatening hematological neoplasms characterized by an uncontrolled proliferation of myeloid progenitors.
Sumaya Basit Abdullah +1 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2021 Aflatoxins (AFs) are metabolised in two main phases in the liver. Cytochrome p450 enzyme (CYP) 1A1 and CYP2A6 are expressed through AhR, CAR and PXR nuclear receptors in phase-1 biotransformation of AFs.
Mehmet Burak Ates, Mustafa Ortatatli
doaj +1 more source
Italian Journal of Animal Science, 2022 The effects of lycopene on liver damage in Aflatoxin B1 (AFB1)-challenged broilers were investigated. A total of 240 Arbour Acres Broilers in five groups were fed basal diet (control), basal diet with 100 μg/kg AFB1 (AFB1), AFB1 diet with 100, 200, and ...
Xiaoli Wan +8 more
doaj +1 more source
RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity. [PDF]
PLoS ONE, 2011 The aryl hydrocarbon receptor (AhR) is a transcription factor activated by several environmental pollutants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and involved in carcinogenesis and various physiological processes, including immune response
David Gilot +6 more
doaj +1 more source
Expression of Aryl Hydrocarbon Receptor (AhR) and Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt) in Adult Rabbits Known to be Non‐Responsive to Cytochrome P ‐450 1A1 (CYP1A1) Inducers [PDF]
European Journal of Biochemistry, 1996 Induction of aryl hydrocarbon hydroxylase by aryl hydrocarbons occurs only in neonatal rabbits and not in adult rabbits [Kahl, G. F., Friederich, D. E., Bigelow, S. W., Okey, A. B. & Nebert, D. W. (1980) Dev. Pharmacol. Ther 1, 137–162], In the present study, we isolated cDNA clones encoding aryl hydrocarbon receptor (AhR) and aryl hydrocarbon ...
Y, Takahashi +4 more
openaire +2 more sources
Role of the aryl hydrocarbon receptor in Sugen 5416-induced experimental pulmonary hypertension [PDF]
, 2018 Rationale: Rats dosed with the vascular endothelial growth factor (VEGF) inhibitor Sugen 5416 (Su), placed in hypoxia then restored to normoxia has become a widely used model of pulmonary arterial hypertension (PAH).
Dean, Afshan +6 more
core +1 more source
Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. [PDF]
, 2008 The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification.
Finn, Robert +3 more
core +2 more sources