Results 11 to 20 of about 8,438 (149)

MiR-18a-5p Attenuates Oxidative Stress and Inhibits Lipid Accumulation in Alcoholic Fatty Liver by Activating the CYP1A1-PPAR Axis. [PDF]

Immun Inflamm Dis
ABSTRACT Background Lipid deposition in alcoholic fatty liver disease (AFL) represents an early stage in alcoholic liver disease progression and may contribute to carcinogenesis. MicroRNAs (miRNAs) play critical regulatory roles in liver biological processes. Methods In this study, we explored the miR‐18a‐5p/CYP1A1/PPAR axis in AFL using bioinformatics
Zhang X, Li W, Ullah U, Li N, Geng X, Qi J, Chen H, Zhang X, Hu Y, Yang L, Jin S.   +10 more
europepmc   +2 more sources

Meta-Analysis of CYP1A1 MspI and Ile462Val Polymorphisms in Cancer Susceptibility Among Different Ethnic Populations. [PDF]

Environ Mol Mutagen
ABSTRACT The Cytochrome P450 1A1 (CYP1A1) gene plays a crucial role in the production of enzymes involved in the metabolic activation and detoxification of harmful carcinogens, which are essential for genetic susceptibility to cancer. Due to the inconsistent findings obtained from population‐based studies, it is crucial to systematically investigate ...
Yousuf A, Khan NU, Unar A.
europepmc   +2 more sources

Effects of Aerosol Extract From Heated Tobacco Products on Senescence-Associated Gene Expression in Human Lung Fibroblasts. [PDF]

Geriatr Gerontol Int
Repeated exposure to aerosols from heated tobacco products may affect senescence‐associated factors. ABSTRACT Aim Cellular senescence is associated with an increased risk of various diseases. Although heated tobacco products (HTPs) have become widespread substitutes for conventional combustible cigarettes, their role in cellular senescence remains ...
Sato A, Kasahara S, Ishigami A.
europepmc   +2 more sources

Evaluation of Indigo Naturalis Prepared Using a Novel Method: Anti-Inflammatory Activities Against Colonic Cancer Cell Lines. [PDF]

Mediators Inflamm
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), and cancerous transformation of UC is closely associated with chronic inflammation of colonic tissues. Indigo naturalis (IN) prepared using a novel method (NIN) has exhibited beneficial efficacy against inflammatory and cancerous colonic cells.
Xu X, Lin L, Ning W, Zhou X, Ullah A, Huang X, Yang H, Wu X, Diao Y.   +8 more
europepmc   +2 more sources

The Ah receptor: adaptive metabolism, ligand diversity, and the xenokine model [PDF]

, 2020
Author Posting. © American Chemical Society, 2020. This is an open access article published under an ACS AuthorChoice License. The definitive version was published in Chemical Research in Toxicology, 33(4), (2020): 860-879, doi:10.1021/acs.chemrestox ...
Avilla, Mele N., Bradfield, Christopher A., Hahn, Mark E., Malecki, Kristen M. C., Wilson, Rachel H.   +4 more
core   +1 more source

Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.) [PDF]

, 2013
Chicory (Cichorium intybus) has been shown to induce enzymes of pharmacokinetic relevance (cytochrome P450; CYP). The aim of this study was to investigate the effects of selected secondary plant metabolites with a global extract of chicory root, on the ...
Ekstrand, Bo, Klausen, Christina Lindgaard, Rasmussen, Martin Krøyer   +2 more
core   +1 more source

Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2 [PDF]

, 2008
Porcine cytochrome P450 (CYP) 1A2 was purified to electrophoretic homogeneity from the hepatic microsomes of -naphthoflavone-treated male pigs. In a reconstituted system, this enzyme showed a good catalytic activity towards caffeine, acetanilide, and ...
Chirulli, Vera, Gervasi, Pier Giovanni, Longo, Vincenzo, Messina, Andrea   +3 more
core   +1 more source

Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study

BMC Cancer, 2010
Background It is uncertain whether smoking is related to colorectal cancer risk. Cytochrome P-450 CYP1A1, glutathione-S-transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are important enzymes in the metabolism of tobacco carcinogens, and ...
Maekawa Takafumi, Futami Kitaroh, Ikejiri Koji, Okamura Takeshi, Maehara Yoshihiko, Kakeji Yoshihiro, Tanaka Masao, Mibu Ryuichi, Nagano Jun, Toyomura Kengo, Yin Guang, Kono Suminori, Nisa Hoirun, Yasunami Yohichi, Takenaka Kenji, Ichimiya Hitoshi, Terasaka Reiji   +16 more
doaj   +1 more source

Metabolic differences in colon mucosal cells [PDF]

, 1993
The colonic expression of cytochromes P450 from the CYP1A, CYP3A and CYP4B subfamilies has been characterized in rabbit and human tissues using RNA blotting, immunoblotting, immunohistochemistry and hybridization histochemistry. These studies demonstrate
Burgess, W. M., Gonzalez, F. J., McKinnon, R. A., McManus, M. E.   +3 more
core   +1 more source

Modulation of CYP1A1 by PKC Inhibitors and TPA Pre-Treatments in MH1C1 Rat Hepatoma Cells Exposed to 3 -Methylcholanthrene [PDF]

, 2009
Cytochrome P4501A1 (CYP1A1), an enzyme known to metabolize polycyclic aromatic hydrocarbons, is regulated by the aryl hydrocarbon receptor (AhR). The involvement of protein kinase C (PKC) in the regulation of AhR signal transduction pathway, has been ...
Bassi, A., Bassi, A., Catalano, M., Catalano, M., De Pascale, C., De Pascale, C., Domenicotti, C., Domenicotti, C., Ledda, S., Ledda, S., Marengo, B., Marengo, B., Nitti, M., Nitti, M., Penco, S., Penco, S., Sanguineti, R., Sanguineti, R., Scanarotti, C., Scanarotti, C., Siri, M., Siri, M.   +21 more
core   +1 more source