Results 41 to 50 of about 8,438 (149)

Constitutive expression and localization of cytochrome P-450 1A1 in rat and human brain: presence of a splice variant form in human brain [PDF]

, 2005
Cytochrome P-450 function as mono-oxygenases and metabolize xenobiotics. CYP1A1, a cytochrome P-450 enzyme, bioactivates polycyclic aromatic hydrocarbons to reactive metabolite(s) that bind to DNA and initiate carcinogenesis.
Chinta, Shankar J., Kommaddi, Reddy P., Ravindranath, Vijayalakshmi, Strobel, Henry W., Turman, Cheri M.   +4 more
core   +1 more source

Clinical assessment of mocravimod as a victim of drug–drug interactions via CYP3A4 metabolism and transporters

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract Mocravimod, a novel immunomodulator targeting sphingosine‐1‐phosphate receptor (S1PR), is being developed as a maintenance treatment for patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation. Preclinical data suggested that cytochrome (CYP) 3A4 is the primary enzyme involved in mocravimod metabolism.
Dymphy R. Huntjens, Stephan Oehen, Elisabeth Kueenburg   +2 more
wiley   +1 more source

Association of The Common CYP1A1*2C Variant (Ile462Val Polymorphism) with Chronic Myeloid Leukemia (CML) in Patients Undergoing Imatinib Therapy

Cell Journal, 2015
Objective: Cytochrome P450 is one of the major drug metabolizing enzyme families and its role in metabolism of cancer drugs cannot be less emphasized. The association between single nucleotide polymorphisms (SNPs) in CYP1A1 and pathogenesis of chronic
Samyuktha Lakkireddy, Sangeetha Aula, Swamy AVN, Atya Kapley, Raghunadha Rao Digumarti, Kaiser Jamil   +5 more
doaj  

Polymorphism of xenobiotic biotransformation enzyme genes and their role in early pregnancy loss

Фундаментальная и клиническая медицина
Considering the progressive decrease in the number of women of fertile age, as well as children and adolescents, the primary medical and social task at the present stage is to preserve the reproductive health and life of women, preserving every desired ...
S. V. Matoshin, S. V. Shramko
doaj   +1 more source

The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) [PDF]

, 2017
The metabolic activation of the heterocyclic food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) by two human cytochrome P450 monooxygenases (P4501A1 and P4501A2) and two human N-acetyltransferases (NAT1 and NAT2) was investigated.
Blum, Martin, D'Orazio, Daniel, Fasshauer, Ingrid, Meyer, Urs A., Probst, Markus R., Wild, Dieter   +5 more
core  

Genetic polymorphism of cytochrome p450 (2C19) enzyme in Iranian Turkman ethnic group [PDF]

, 2013
Objective: Different findings indicate that CYP2C plays a clinical role in determining interindividual and interethnic differences in drug effectiveness. The ethnic differences in the frequency of CYP2C19 mutant alleles continue to be a significant study
Ataby, O.A., Mansourian, A.R., Marjani, A., Samai, N.M., Tabari, R.G.   +4 more
core   +2 more sources

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, Volume 13, Issue 3, 14 January 2026.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan [PDF]

, 2016
A list of SNPs that were not found in heterozygous or homozygous variants.
Aisha N. Iskakova, Akbota M. Aitkulova, Aliya A. Romanova, Elena V. Zholdybayeva, Erlan M. Ramanculov, Nurgul S. Sikhayeva   +5 more
core   +5 more sources

Structural Impact of 4‐Hydroxynonenal Modification on Human Cytochrome CYP4F11

ChemMedChem, Volume 21, Issue 2, January 2026.
Protein lipoxidation by 4‐hydroxynonenal induces conformational and stability changes in human CYP4F11, as revealed by DSC, FTIR, and Raman spectroscopy, with potential consequences for enzymatic function. Posttranslational modifications of human enzymes play a crucial role in disease development. 4‐hydroxynonenal (4‐HNE), a lipid peroxidation product,
Olena Gnatyuk, Oleksii Skorokhod, Alessandro Damin, Mykhailo Chaika, Fateme Naeimaeirouhani, Loris Pica, Anita Tomatis, Aleksandra Smorygo, Taras Voitsitskyi, Gianluca Catucci, Galyna Dovbeshko, Gianfranco Gilardi   +11 more
wiley   +1 more source

Indole‐3‐Acetic Acid Improves Intestinal Inflammation and Intestinal Barrier Dysfunction In Vitro via the AHR/NF‐κB Signaling Pathway

Food Frontiers, Volume 7, Issue 1, January 2026.
In this study, we found that based on the AHR/NF‐κB signaling pathway, IAA has a positive effect on the prevention and treatment of intestinal barrier function and also exhibits immunological activity. ABSTRACT Impairment of intestinal barrier function is intricately linked to intestinal inflammation.
Qiaoyu Sun, Qingqing Zhou, Sitong Ge, Danli Wu, Ping Li, Qing Gu   +5 more
wiley   +1 more source