Results 51 to 60 of about 8,438 (149)

Pharmacovigilance‐Based Identification and Mechanistic Exploration of Periodontitis‐Related Drugs

Journal of Clinical Periodontology, Volume 53, Issue 1, Page 117-126, January 2026.
ABSTRACT Background Periodontitis is a common chronic inflammatory disease. However, drug‐related risks and underlying molecular mechanisms remain underexplored from large real‐world data. Methods We first mined the US Food and Drug Administration Adverse Event Reporting System (FAERS) database to identify drugs disproportionately associated with ...
Wuda Huoshen, Junkai Xiong, Xunmi Ma, Heng Wang, Panyu Cheng, Xinyu Chen, Ge Shuai, Yi Chen, Xinyue Zhang, Chen Sun, Chunhui Li, Rui Shi   +11 more
wiley   +1 more source

Biomonitoring of the genotoxic potential (micronucleus assay) and detoxifying activity (EROD induction) in the River Dadou (France), using the amphibian Xenopus laevis [PDF]

, 2004
Within the framework of a general survey of the water quality of the river Dadou (Tarn, France), different physicochemical parameters were measured and an inventory of the fish population was made along the water course, around the Rassisse dam.With the ...
Gauthier, Laury, Marty, Josette, Mouchet, Florence, Tardy, Emmanuelle   +3 more
core   +2 more sources

Effect of Tumour Necrosis Factor-Alpha on Estrogen Metabolic Pathways in Breast Cancer Cells

Journal of Cancer, 2012
Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that has been linked to breast cancer development. Estrogen metabolic pathway is also involved in breast carcinogenesis and DNA adducts formation.
Marwa Kamel, Samia Shouman, Mahmoud El-Merzebany, Gokhan Kilic, Timothy Veenstra, Muhammad Saeed, Mohamed Wagih, Concepcion Diaz-Arrastia, Deepa Patel, Salama Salama
doaj  

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice [PDF]

, 2015
The tumour suppressor p53 is one of the most important cancer genes. Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the
Albrecht Seidel, Annette M. Krais, David H. Phillips, Ewoud N. Speksnijder, Frederik-J. van Schooten, Heinz H. Schmeiser, Joost P. M. Melis, Klaus Kopka, Marie Stiborova, Michaela Moserova, Mirjam Luijten, Radek Indra, Roger W. Godschalk, Volker M. Arlt   +13 more
core   +3 more sources

The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes

International Journal of Cancer, Volume 157, Issue 8, Page 1600-1612, 15 October 2025.
What's New? The rarity of acute lymphoblastic leukaemia and lack of available environmental data have made the role of environmental factors in genetic subtypes challenging to investigate. Here, the authors performed a CpG‐level analysis to investigate DNA methylation as an intermediate mechanism between environmental risk exposures and acute ...
Jessica R. Saville, Lisa J. Russell, Kay Padget, Akram Ghantous, Jessica Nordlund, Jill A. McKay   +5 more
wiley   +1 more source

The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 4, October 2025.
ABSTRACT Cytochrome P450 3A4 (CYP3A4) is one of the most important members of the cytochrome P450 subfamily, which is involved in the catalytic process of many drug activation or deactivation. Meanwhile, it is also a risk factor for drug‐induced toxic reactions.
Fang Wang, Xiwei Gu, Haiying Hong, Qianqian Xia, Yuxin Zhang, Ying Song, Baoxin Li, Pan Fan   +7 more
wiley   +1 more source

The AhR Is a Critical Regulator of the Pulmonary Response to Cannabis Smoke

The FASEB Journal, Volume 39, Issue 18, 30 September 2025.
AhR activation coordinates the pulmonary response to cannabis smoke. Inhalation of cannabis smoke disrupts epithelial integrity and promotes inflammation. AhR is activated by cannabis smoke and regulates cytoskeletal structure, detoxification, antioxidant, and immune pathways.
Emily T. Wilson, Roham Gorgani, Nicole S. Heimbach, Alexandra Bartolomucci, Thupten Tsering, Julia V. Burnier, David H. Eidelman, Carolyn J. Baglole   +7 more
wiley   +1 more source

Reciprocal Modulation of Hepatic Cytochrome P450 Gene Expressions with Streptozotocin Induced Diabetes and Resveratrol [PDF]

, 2011
Cytochrome P450s are very large and diverse superfamily of hemoproteins found in all domains of life and diverse array of compounds can influence the relative concentrations and/or activities of P450s.
Sadi, Gökhan, Sadi, Özlem
core  

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, Volume 12, Issue 36, September 25, 2025.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source