Effect of CYP1A1 gene polymorphism and psychological distress on seminal analysis parameters [PDF]
, 2016 BACKGROUND: Psychological factor alters fertility hormones and contributes to male infertility. Anxiety and depression are common manifestations of psychological distress.
Aditi Singh +6 more
core +1 more source
Current trends in drug metabolism and pharmacokinetics. [PDF]
, 2019 Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion (ADME) processes of a drug. Understanding PK properties is essential for drug development and precision medication.
Abduljalil +332 more
core +1 more source
Association of warfarin dose with genes involved in its action and metabolism [PDF]
, 2007 We report an extensive study of variability in genes encoding proteins that are believed to be involved in the action and biotransformation of warfarin.
Mia Wadelius +73 more
core +1 more source
Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency [PDF]
, 2017 Previous work has demonstrated that the function of extrahepatic cytochrome P450 CYP1A1 is dependent on the availability of heme. CYP1A1 is involved in the activation of polyaromatic hydrocarbons.
Hoffmann, Francine +3 more
core
Steroid biotransformations in biphasic systems with Yarrowia lipolytica expressing human liver cytochrome P450 genes [PDF]
, 2012 BACKGROUND: Yarrowia lipolytica efficiently metabolizes and assimilates hydrophobic compounds such as n-alkanes and fatty acids. Efficient substrate uptake is enabled by naturally secreted emulsifiers and a modified cell surface hydrophobicity and ...
Braun, Andreas +5 more
core +2 more sources
Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene: protective effect of S-adenosylmethionine [PDF]
, 2001 Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the synthesis of S-adenosylmethionine (AdoMet), the most important biological methyl donor. Liver MAT I/III is the product of the MAT1A gene.
Avila, M.A. (Matías Antonio) +6 more
core
Development of q-PCR approaches to assess water quality: Effects of cadmium on gene expression of the diatom Eolimna minima [PDF]
, 2012 This study was undertaken to develop molecular tools to assess water quality using diatoms as the biological model. Molecular approaches were designed following the development of a rapid and easy RNA extraction method suited to diatoms and the ...
DAFFE, Guillemine +7 more
core +4 more sources
Association of (Ile462Val in genetic polymorphisms CYP1A1) and uterine leiomyoma risk in women in Charmahal va Bakhtiari, I.R. Iran [PDF]
, 2012 زمینه و هدف: لیومیوم رحمی شایعترین تومور خوش خیم عضلات صاف رحم میباشد و تقریباً در ٢٥ تا ٣٠ زنان بالای ٣٠ سال رخ میدهد. رشد و پیشرفت لیومیوم وابسته به استروژن بود و نقش ژن سیتوکروم 450P- کلاس 1A1 (CYP1A1) در متابولیسم استروژن بررسی شده است.
Ashoori, Saeede. +6 more
core
The aryl hydrocarbon receptor and retinoid receptors cross-talk at the CYP1A1 promoter in vitro [PDF]
The epithelium of the small intestine plays an important role in detoxification processes due to the presence of various xenobiotic-metabolizing enzymes from phase I and II, as well as transport proteins of the ATP-binding cassette superfamily.
Braeuning, Albert +3 more
core +1 more source
Cellular and Viral Determinants for Hepatitis C Virus Replication
, 2011 The recent discovery of an HCV isolate which replicates in cell culture has opened up opportunities to study the full viral life cycle in vitro. This genotype 2a isolate (JFH-1) and its derivatives are the only ones known to replicate efficiently in cell
Baillie, Andrew James +1 more
core +1 more source