Results 41 to 50 of about 10,403 (155)

Review of QSAR Models and Software Tools for predicting Biokinetic Properties [PDF]

, 2010
In the assessment of industrial chemicals, cosmetic ingredients, and active substances in pesticides and biocides, metabolites and degradates are rarely tested for their toxicologcal effects in mammals.
MOSTRAG-SZLICHTYNG A., WORTH Andrew
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In Vitro Assessment of Drug‐Induced Liver Injury Using Three‐Dimensional Cultured HepaSH Cells Derived From Chimeric Mouse Model With Humanized Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Drug‐induced liver injury (DILI) is a serious adverse event and a common cause of postmarketing drug withdrawal. Despite nonclinical assessments of DILI risk, which are predominantly conducted in experimental animals, DILI remains a frequent adverse event, highlighting the need to improve nonclinical assessments.
Xingming Liu, Yuichiro Higuchi, Yuta Sakamoto, Shota Yanagida, Shotaro Uehara, Hiroshi Suemizu, Yasunari Kanda, Hiroyuki Kawagishi   +7 more
wiley   +1 more source

Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study). [PDF]

, 2017
It is well known that the standard doses of a given drug may not have equivalent effects in all patients. To date, the management of depression remains mainly empirical and often poorly evaluated.
Bellivier, F., Besson, M., Calvas, F., Chevret, S., Courtet, P., Cracowski, J.L., Daali, Y., Davani, S., Desmeules, J., Desmidt, T., Doumy, O., Déglon, J., El-Hage, W., Galtier, F., Haesebaert, F., Haffen, E., Heron, K., Holtzmann, J., Le Corvoisier, P., Leboyer, M., Llorca, P.M., Lloret-Linares, C., Molière, F., Montange, D., Morange, S., Nieto, I., Richieri, R.M., Vignaud, P., Yon, L., Yrondi, A.   +29 more
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Evaluation of the Pharmacokinetics, Disposition, and Metabolism of Miricorilant, a Novel Glucocorticoid Receptor Modulator for the Treatment of Metabolic Dysfunction‐Associated Steatohepatitis in Nonclinical and Clinical Studies

The Journal of Clinical Pharmacology, EarlyView.
Abstract Miricorilant is a novel selective glucocorticoid receptor (GR) modulator with mixed agonist/antagonist effects at the GR and modest antagonism at the mineralocorticoid receptor that is being developed for the treatment of metabolic dysfunction‐associated steatohepatitis.
Hazel J. Hunt, Kirsteen M. Donaldson, Jeevan R. Kunta, Joseph M. Custodio   +3 more
wiley   +1 more source

Pharmacovigilance‐Based Identification and Mechanistic Exploration of Periodontitis‐Related Drugs

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Background Periodontitis is a common chronic inflammatory disease. However, drug‐related risks and underlying molecular mechanisms remain underexplored from large real‐world data. Methods We first mined the US Food and Drug Administration Adverse Event Reporting System (FAERS) database to identify drugs disproportionately associated with ...
Wuda Huoshen, Junkai Xiong, Xunmi Ma, Heng Wang, Panyu Cheng, Xinyu Chen, Ge Shuai, Yi Chen, Xinyue Zhang, Chen Sun, Chunhui Li, Rui Shi   +11 more
wiley   +1 more source

Pharmacogenetics of Selective Serotonin Reuptake Inhibitors and Associated Adverse Drug Reactions [PDF]

, 2009
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90075/1/phco.29.7.822 ...
Ellingrod, Vicki L., Thomas, Kelan L. H.
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Serotonin (5‐Hydroxytryptamine): Metabolism, Signaling, Biological Functions, Diseases, and Emerging Therapeutic Opportunities

MedComm, Volume 6, Issue 9, September 2025.
This article reviews the roles of 5‐HT metabolism, 5‐HT receptors, and their related signaling pathways in normal physiology and various diseases, and explores their potential value in disease treatment, providing a reference basis for research and clinical treatment in related fields. ABSTRACT Serotonin (5‐hydroxytryptamine; 5‐HT) is an evolutionarily
Yuxin Zhang, Nan Wang, Louqian Zhang, Yan Zhuang, Qilei Xin, Xiaosong Gu, Chunping Jiang, Junhua Wu   +7 more
wiley   +1 more source

Clinical applications of pharmacogenomics [PDF]

, 2017
Indexación: Scopus.Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution ...
Cayún, J.P., Escalante, P., Gallegos, B., Lares-Asseff, I., Meneses, F., Miranda, C., Quiñones, L., Roco, Á., Varela, N., Zaruma-Torres, F.   +9 more
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Discovery of a Phenylalanine‐Derived Natural Compound as a Potential Dual Inhibitor of MDM2 and MDMX

ChemMedChem, Volume 20, Issue 16, August 16, 2025.
P5, a novel phenylalanine‐derived compound isolated from Micromonospora sp. MS‐62, exhibits dual inhibition of MDM2 and MDMX. Molecular docking and SPR confirm its nanomolar affinity and sustained binding kinetics. In silico profiling reveals high GI absorption, BBB permeability, and drug‐likeness, highlighting its potential as a lead for p53‐targeted ...
Ja Young Cho, Sanghwa Park, Taejung Kim, Junghye Eom, Jung‐Rae Rho, Hyoung‐Woo Bai   +5 more
wiley   +1 more source

CYP2D6 genotype and adjuvant tamoxifen:meta-analysis of heterogeneous study populations [PDF]

, 2014
The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated
Altman, R. B., Altman, Russ B., Ambrosone, C. B., Ambrosone, Christine A., Ambrosone, Christine B., Ames, M. M., Beckmann, M. W., Beckmann, Matthias W., Boländer, Julia, Brauch, H., Brauch, Hiltrud, Choi, J. Y., Choi, Ji Yeob, Dieudonné, A. S., Dieudonné, Anne Sophie, Eichelbaum, M., Eichelbaum, Michel, Fasching, P. A., Fasching, Peter A., Ferraldeschi, R., Ferraldeschi, Roberta, Fischer-Bosch, Margarete, Flockhart, D. A., Flockhart, David A., Fritz, Peter, Goetz, M. P., Goetz, Matthew P., Gong, L., Gong, Li, H, Elad Ziv, Hamann, U., Hamann, Ute, Haschke-Becher, E., Haschke-Becher, Elisabeth, Hebert, J. M., Hebert, Joan M., Howell, Anthony, Ingle, J. N., Ingle, James N., Jordan, L. B., Jordan, Lee B., Jordan, V. C., Kiyotani, K., Kiyotani, Kazuma, Klein, T. E., Klein, Teri E., Koelbl, Heinz, Krippl, P., Lambrechts, D., Lambrechts, Diether, Langsenlehner, U., Latif, A., Latif, Ayse, Lee, M. T M, Lorizio, W., Lorizio, Wendy, Mushiroda, T., Mushiroda, Taisei, Nakamura, Y., Neven, P., Neven, Patrick, Newman, W. G., Newman, William G., Nguyen, A. T., Nguyen, Anne T., Park, B. W., Park, Byeong Woo, Province, M. A., Province, Michael A., Purdie, C. A., Purdie, Colin A., Quinlan, P., Quinlan, Philip, Renner, W., Schmidt, M., Schmidt, Marcus, Schroth, W., Schroth, Werner, Schwab, M., Schwab, Matthias, Shin, J. G., Shin, Jae Gook, Simon, Wolfgang, Stingl, J. C., Stingl, Julia C., Strick, Reiner, Suman, V. J., Suman, Vera J., Thompson, A. M., Thompson, Alastair M., Ulmer, Hans Ulrich, Wegman, P., Wegman, Pia, Weinshilboum, R. M., Weinshilboum, Richard M., Whaley, R., Whaley, Ryan, Wingren, S., Wingren, Sten, Winter, S., Winter, Stefan, Wu, A. H B, Wu, Alan H B, Zembutsu, H., Zembutsu, Hitoshi, Zirpoli, G., Ziv, E., Ziv, Elad   +107 more
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