Results 51 to 60 of about 10,403 (155)

Population Genetic-Based Pharmacokinetic Modeling of Methadone and its Relationship with the QTc Interval in Opioid-Dependent Patients. [PDF]

, 2016
Methadone is a μ-opioid agonist widely used for the treatment of pain, and for detoxification or maintenance treatment in opioid addiction. It has been shown to exhibit large pharmacokinetic variability and concentration-QTc relationships.
Eap, C.B., Guidi, M.
core   +1 more source

Phytochemical Profiling, Antioxidant Capacity, and the Antidiabetic Potential of Atriplex halimus Extracts: UHPLC–MS/MS Analysis, In Vitro Enzyme Inhibition Assays, and Molecular Docking Studies

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Atriplex halimus extracts exhibited significant antidiabetic activity, notably inhibiting α‐amylase and hemoglobin glycation. UHPLC‐MS/MS analysis identified 21 phytochemicals, with trans‐cinnamic acid being the most abundant. Molecular docking revealed catechin and epigallocatechin as key bioactive compounds with strong binding affinities, surpassing ...
Mohammed Roubi, Nour Elhouda Daoudi, Mohammed Dalli, Salah‐eddine Azizi, Youness Mahdi, Ramzi A. Mothana, Hanan M. Al‐Yousef, Mohammed F. Hawwal, Fahd Kandsi, Raffaele Conte, Nadia Gseyra   +10 more
wiley   +1 more source

Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil

Drug Design, Development and Therapy, 2020
Marion Ortner,1 Marion Stange,1 Heike Schneider,1 Charlotte Schröder,2 Katharina Buerger,3 Claudia Müller,3 Felix Müller-Sarnowski,1 Janine Diehl-Schmid,1 Hans Förstl,1 Timo Grimmer1 ,* Werner Steimer2, * 1Department of Psychiatry and
Ortner M, Stange M, Schneider H, Schröder C, Buerger K, Müller C, Müller-Sarnowski F, Diehl-Schmid J, Förstl H, Grimmer T, Steimer W   +10 more
doaj  

Polymorphic drug metabolising enzymes:Assessment of activities by phenotyping and genotyping in clinical pharmacology [PDF]

, 2001
Drug effects (pharmacodynamics) are determined by drug concentration at target site and the affinity of the drug for a target. Pharmacogenetics describes inherited differences in drug metabolising enzyme activities and differences in drug transporters ...
Tamminga, Willem Jan
core   +2 more sources

Eletriptan in the management of acute migraine. An update on the evidence for efficacy, safety, and consistent response [PDF]

, 2016
Migraine is a multifactorial, neurological and disabling disorder, also characterized by several autonomic symptoms. Triptans, selective serotonin 5-HT1B/1D agonists, are the first-line treatment option for moderate-to-severe headache attacks.
Capi, Matilde, Curto, Martina, De Andrés, Fernando, Gentile, Giovanna, Lionetto, Luana, Martelletti, Paolo, Negro, Andrea   +6 more
core   +1 more source

Drug Exposure in Chronic Kidney Disease: It Is Not Just About the Glomerular Filtration Rate

Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT Chronic kidney disease (CKD) affects over 10% of the world's population and is associated with high morbidity and mortality rates. The management of CKD is complex; CKD alters drug pharmacokinetics and pharmacodynamics and further complicates therapeutic strategies regimens.
Sophie Liabeuf, Jessica Berdougo‐Tritz, Lucie Augey, Aïcha Mbarek, Michel Jadoul, Gilbert Deray, Ziad A. Massy   +6 more
wiley   +1 more source

Economic Impact of the Application of a Precision Medicine Model (5SPM) on Psychotic Patients

Pharmacogenomics and Personalized Medicine, 2021
Lorena Carrascal-Laso,1 Manuel Ángel Franco-Martín,1 Elena Marcos-Vadillo,2 Ignacio Ramos-Gallego,3 Belén García-Berrocal,2 Eduardo Mayor-Toranzo,1 Santiago Sánchez-Iglesias,4 Carolina Lorenzo,4 Alfonso Sevillano-Jiménez,1 Almudena Sánchez-Martín,5 María
Carrascal-Laso L, Franco-Martín M, Marcos-Vadillo E, Ramos-Gallego I, García-Berrocal B, Mayor-Toranzo E, Sánchez-Iglesias S, Lorenzo C, Sevillano-Jiménez A, Sánchez-Martín A, García-Salgado MJ, Isidoro-García M   +11 more
doaj  

Pharmacogenetics and individualizing drug treatment during pregnancy [PDF]

, 2014
Pharmacogenetics as a tool to aid clinicians implement individualized pharmacotherapy is utilized in some areas of medicine. Pharmacogenetics in pregnancy is still a developing field.
Haas, David M.
core   +1 more source

Expert Consensus on the Clinical Application of PI3K/AKT/mTOR Inhibitors in the Treatment of Breast Cancer (2025 Edition)

Cancer Innovation, Volume 4, Issue 3, June 2025.
ABSTRACT Background The phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) plays a critical role in breast cancer pathogenesis and progression, and is closely linked with resistance to endocrine therapy in advanced breast cancer.
The Breast Cancer Expert Committee of the National Quality Control Center for Cancer, The Expert Committee on Cancer Prevention and Treatment of the Health China Research Center, The Society of Clinical Research on Oncology Medications of the China Anti‐Cancer Association, The Society of Onco‐Pathology of the China Anti‐Cancer Association   +3 more
wiley   +1 more source

A study of associations of polymorphic variants of cytochrome P-450 system genes and multi-drug resistance gene with the development of druginduced hyperprolactinemia in patients with schizophrenia [PDF]

, 2017
The detection of clinical and biological associations in different alleles and genotypes allows to create the fundament for development methods, which help to identify risk of side-effects in patients with schizophrenia, who received long-term ...
Воронина, Е. Н., Пожидаев, И. В.   +1 more
core