Results 51 to 60 of about 10,662 (153)

Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil

Drug Design, Development and Therapy, 2020
Marion Ortner,1 Marion Stange,1 Heike Schneider,1 Charlotte Schröder,2 Katharina Buerger,3 Claudia Müller,3 Felix Müller-Sarnowski,1 Janine Diehl-Schmid,1 Hans Förstl,1 Timo Grimmer1 ,* Werner Steimer2, * 1Department of Psychiatry and
Ortner M, Stange M, Schneider H, Schröder C, Buerger K, Müller C, Müller-Sarnowski F, Diehl-Schmid J, Förstl H, Grimmer T, Steimer W   +10 more
doaj  

Current trends in drug metabolism and pharmacokinetics. [PDF]

, 2019
Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion (ADME) processes of a drug. Understanding PK properties is essential for drug development and precision medication.
Abduljalil, Aghazadeh-Habashi, Aigrain, Aitman, Al Za'abi, Alegre, Alnaqeeb, Aspromonte, Babiskin, Baert, Bakke, Barnett, Bhattacharyya, Cang, Cannady, Cao, Cao, Capecchi, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Cheng, Cheng, Crawford, Currie, De Lange, Dean, Deng, Di Paolo, Dietrich, Diliberto, Dluzen, Dowling, Dragin, Dreisbach, Duan, Edeogu, Edginton, El-Arabey, El-Kadi, EMA, Eum, Falany, Fang, FDA, Feng, Feng, Feng, Ferri, Fleming, Foti, Fox, Freedman, Frye, Fukami, Gaj, Gan, Gao, Gao, Gao, Gao, Gao, Ge, Genovese, Gingell, Gingell, Gong, Graham, Gufford, Guo, Guo, Guo, Guévin, Han, Harrison, Hartz, Hasegawa, He, He, He, He, He, Ho, Ho, Hou, Hsu, Hsueh, Hu, Hu, Hu, Huo, Hwang, Ito, Jacob, Jeong, Jeong, Jia, Jian, Jiang, Jiang, Jiang, Jiang, Jilek, Jilek, Johnson, Jorga, Jung, Kaivosaari, Kalthoff, Kaminsky, Kannan, Karibe, Kesisoglou, Kim, Kim, Knights, Kong, Kota, Kumar, Kurokawa, Lai, Lan, Lanchote, Lee, Lehouritis, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Liang, Lin, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Lopes-Rodrigues, Lu, Lu, Lu, Löfgren, Mano, Marchitti, Margolskee, Martin, Matsson, Mattick, Mazerska, Mei, Mencia, Meng, Min, Mitra, Miyajima, Müller, Nair, Nakano, Nakano, Nakano, Nebert, Nguyen, Niederalt, Nieto Montesinos, Niu, Notenboom, Nozaki, Ohtsuki, Ono, Oostendorp, Pan, Pan, Papageorgiou, Papageorgiou, Park, Pea, Pedersen, Pelkonen, Pellegrino, Pettersson Bergstrand, Qi, Qin, Qiu, Qiu, Raaska, Rives, Riviere, Roberts, Robey, Rocha, Rose, Routy, Rowland, Ruwali, Saini, Satoh, Savage, Scheer, Scheer, Schlender, Schmitt, Schneider, Seitz, Showande, Shu, Shu, Shu, Shugarts, Siu, Song, Staudinger, Strong, Suarez-Sharp, Suh, Suiko, Sukkummee, Sun, Sun, Sutliff, Takeda, Tan, Tan, Tao, Tatsumi, Teorell, Tsai, Tsang, Tsuchiya, Tsume, Tu, Ulldemolins, van Waterschoot, von Richter, Vugmeyster, Vuppugalla, Wagner, Wagner, Wagner, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wassenaar, Watanabe, Wei, Wijayakumara, Wilkinson, Wong, Wu, Xia, Xie, Xie, Xu, Xu, Xu, Xu, Xu, Xue, Yamagata, Yamaguchi, Yan, Yang, Yang, Yang, Ye, Yellepeddi, Yi, Yi, Yigitaslan, Yim, Yin, Yoshida, Yoshida, Yoshimi, Yu, Yu, Yu, Yu, Yu, Yu, Yu, Zakeri-Milani, Zanger, Zeng, Zeng, Zhai, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhao, Zhao, Zhou, Zhou, Zhou, Zhou, Zhou, Zhu, Zhu, Zhu, Zhuang, Zimmermann   +332 more
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Pharmacovigilance‐Based Identification and Mechanistic Exploration of Periodontitis‐Related Drugs

Journal of Clinical Periodontology, Volume 53, Issue 1, Page 117-126, January 2026.
ABSTRACT Background Periodontitis is a common chronic inflammatory disease. However, drug‐related risks and underlying molecular mechanisms remain underexplored from large real‐world data. Methods We first mined the US Food and Drug Administration Adverse Event Reporting System (FAERS) database to identify drugs disproportionately associated with ...
Wuda Huoshen, Junkai Xiong, Xunmi Ma, Heng Wang, Panyu Cheng, Xinyu Chen, Ge Shuai, Yi Chen, Xinyue Zhang, Chen Sun, Chunhui Li, Rui Shi   +11 more
wiley   +1 more source

Economic Impact of the Application of a Precision Medicine Model (5SPM) on Psychotic Patients

Pharmacogenomics and Personalized Medicine, 2021
Lorena Carrascal-Laso,1 Manuel Ángel Franco-Martín,1 Elena Marcos-Vadillo,2 Ignacio Ramos-Gallego,3 Belén García-Berrocal,2 Eduardo Mayor-Toranzo,1 Santiago Sánchez-Iglesias,4 Carolina Lorenzo,4 Alfonso Sevillano-Jiménez,1 Almudena Sánchez-Martín,5 María
Carrascal-Laso L, Franco-Martín M, Marcos-Vadillo E, Ramos-Gallego I, García-Berrocal B, Mayor-Toranzo E, Sánchez-Iglesias S, Lorenzo C, Sevillano-Jiménez A, Sánchez-Martín A, García-Salgado MJ, Isidoro-García M   +11 more
doaj  

Population Genetic-Based Pharmacokinetic Modeling of Methadone and its Relationship with the QTc Interval in Opioid-Dependent Patients. [PDF]

, 2016
Methadone is a μ-opioid agonist widely used for the treatment of pain, and for detoxification or maintenance treatment in opioid addiction. It has been shown to exhibit large pharmacokinetic variability and concentration-QTc relationships.
Eap, C.B., Guidi, M.
core   +1 more source

In Vitro Assessment of Drug‐Induced Liver Injury Using Three‐Dimensional Cultured HepaSH Cells Derived From Chimeric Mouse Model With Humanized Liver

Journal of Applied Toxicology, Volume 45, Issue 12, Page 2641-2653, December 2025.
ABSTRACT Drug‐induced liver injury (DILI) is a serious adverse event and a common cause of postmarketing drug withdrawal. Despite nonclinical assessments of DILI risk, which are predominantly conducted in experimental animals, DILI remains a frequent adverse event, highlighting the need to improve nonclinical assessments.
Xingming Liu, Yuichiro Higuchi, Yuta Sakamoto, Shota Yanagida, Shotaro Uehara, Hiroshi Suemizu, Yasunari Kanda, Hiroyuki Kawagishi   +7 more
wiley   +1 more source

Pharmacokinetic and pharmacodynamic characteristics of aripiprazole

Psychiatry and Clinical Psychopharmacology, 2021
Efforts have continued to introduce new antipsychotics with different mechanisms of action following the clinical use of typical antipsychotics for the last fifty years. Among all atypical antipsychotics, aripiprazole has attracted attention since it is
Haldun Soygür
doaj  

CYP2D6 genotype and adjuvant tamoxifen:meta-analysis of heterogeneous study populations [PDF]

, 2014
The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated
Altman, R. B., Altman, Russ B., Ambrosone, C. B., Ambrosone, Christine A., Ambrosone, Christine B., Ames, M. M., Beckmann, M. W., Beckmann, Matthias W., Boländer, Julia, Brauch, H., Brauch, Hiltrud, Choi, J. Y., Choi, Ji Yeob, Dieudonné, A. S., Dieudonné, Anne Sophie, Eichelbaum, M., Eichelbaum, Michel, Fasching, P. A., Fasching, Peter A., Ferraldeschi, R., Ferraldeschi, Roberta, Fischer-Bosch, Margarete, Flockhart, D. A., Flockhart, David A., Fritz, Peter, Goetz, M. P., Goetz, Matthew P., Gong, L., Gong, Li, H, Elad Ziv, Hamann, U., Hamann, Ute, Haschke-Becher, E., Haschke-Becher, Elisabeth, Hebert, J. M., Hebert, Joan M., Howell, Anthony, Ingle, J. N., Ingle, James N., Jordan, L. B., Jordan, Lee B., Jordan, V. C., Kiyotani, K., Kiyotani, Kazuma, Klein, T. E., Klein, Teri E., Koelbl, Heinz, Krippl, P., Lambrechts, D., Lambrechts, Diether, Langsenlehner, U., Latif, A., Latif, Ayse, Lee, M. T M, Lorizio, W., Lorizio, Wendy, Mushiroda, T., Mushiroda, Taisei, Nakamura, Y., Neven, P., Neven, Patrick, Newman, W. G., Newman, William G., Nguyen, A. T., Nguyen, Anne T., Park, B. W., Park, Byeong Woo, Province, M. A., Province, Michael A., Purdie, C. A., Purdie, Colin A., Quinlan, P., Quinlan, Philip, Renner, W., Schmidt, M., Schmidt, Marcus, Schroth, W., Schroth, Werner, Schwab, M., Schwab, Matthias, Shin, J. G., Shin, Jae Gook, Simon, Wolfgang, Stingl, J. C., Stingl, Julia C., Strick, Reiner, Suman, V. J., Suman, Vera J., Thompson, A. M., Thompson, Alastair M., Ulmer, Hans Ulrich, Wegman, P., Wegman, Pia, Weinshilboum, R. M., Weinshilboum, Richard M., Whaley, R., Whaley, Ryan, Wingren, S., Wingren, Sten, Winter, S., Winter, Stefan, Wu, A. H B, Wu, Alan H B, Zembutsu, H., Zembutsu, Hitoshi, Zirpoli, G., Ziv, E., Ziv, Elad   +107 more
core   +3 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Pharmacological aspects of neonatal antidepressant withdrawal [PDF]

, 2008
Depression is common in reproductive age women, and continued pharmacologic treatment of depression during pregnancy may be necessary to prevent relapse, which could be harmful for both the fetus and the mother. Although data on drug safety are imperfect
Brouwers, Jacobus R. B. J., de Jong-van den Berg, Lolkje T. W., Jansman, Frank G. A., Smit, Jan-Pieter, ter Horst, Peter G. J., van Lingen, Richard A.   +5 more
core   +2 more sources