Results 91 to 100 of about 778,835 (257)

Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin [PDF]

, 2017
The rate-limiting step in the steroid synthesis pathway is catalyzed by CYP11A1 through three sequential reactions. The first two steps involve hydroxylations at positions 22 and 20, generating 20(R),22(R)-dihydroxycholesterol (20R,22R-DiOHCH), with the ...
Kincaid, James R., Mak, Piotr J., Tuckey, Robert C., Zhu, Qianhong   +3 more
core   +3 more sources

Furin inhibits HSCs activation and ameliorates liver fibrosis by regulating PTEN‐L/PINK1/parkin mediated mitophagy in mouse

FASEB BioAdvances, EarlyView.
Furin interacted with PTEN‐L and activated PINK1/Parkin‐mediated mitophagy in HSCs. Furin inhibited HSC activation and alleviated liver fibrosis by regulating the PTEN‐L/PINK1/Parkin axis. Abstract Hepatic Stellate cells (HSCs) play an important role during liver fibrosis progression; more and more evidence indicates that mitophagy greatly regulates ...
Yan‐Wei Song, Yu‐Hua Zhu, Ming‐Ze Ma   +2 more
wiley   +1 more source

The control of phenotype: connecting enzyme variation to physiology [PDF]

arXiv, 2002
Metabolic control analysis (Kacser & Burns (1973). Symp. Soc. Exp. Biol. 27, 65-104; Heinrich & Rapoport (1974). Eur. J. Biochem. 42, 89-95) was developed for the understanding of multi-enzyme networks. At the core of this approach is the flux summation theorem.
arxiv  

Chromosome‐level genome assembly and population genomic analysis provide insights into the genetic diversity and adaption of Schizopygopsis younghusbandi on the Tibetan Plateau

Integrative Zoology, EarlyView.
We have constructed the chromosome‐scale genome and investigated the evolutionary genomics of Schizopygopsis younghusbandi, a fish species native to the Yarlung Tsangpo River on the Tibetan Plateau. Our study indicated that this species diverged from other Schizothoracine fish approximately 4.2 million years ago, during the Neogene Tibetan uplift ...
Chaowei ZHOU, Yan ZHOU, Luohao XU, Fei LIU, Luo LEI, He GAO, Junting LI, Suxing FU, Yuting DUAN, Yougang TAN, Weihua MAO, Qiming WANG, Rongzhu ZHOU, Shijun XIAO, Chuan LIU, Haiping LIU   +15 more
wiley   +1 more source

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez, Núria Gaja‐Capdevila, Laura Mosqueira‐Martín, Mireia Herrando‐Grabulosa, Laura Rodriguez‐Gomez, Klaudia Gonzalez‐Imaz, Ana C. Calvo, Maialen Sagartzazu‐Aizpurua, Leticia Moreno‐García, Jose Manuel Fuentes, Abraham Acevedo‐Arozena, Jesús María Aizpurua, José Ignacio Miranda, Adolfo López de Munain, Ainara Vallejo‐Illarramendi, Xavier Navarro, Rosario Osta, Francisco Javier Gil‐Bea   +17 more
wiley   +1 more source

The Barrier Properties of Biological Membranes Dictate How Cells Experience Oxidative Stress

Molecular Microbiology, EarlyView.
Molecular oxygen diffuses across membranes with such speed that, despite respiration, the intracellular oxygen concentration does not differ significantly from that outside the cell. In contrast, membranes are important barriers for hydrogen peroxide and especially superoxide, so that intracellular scavenging enzymes can substantially shield cells from
James A. Imlay
wiley   +1 more source

Repeated colonisation of alpine habitats by Arabidopsis arenosa involved parallel adjustments of leaf cuticle traits

New Phytologist, EarlyView.
Summary Cuticle function can be pivotal to plant success in different environments. Yet, the occurrence of intraspecific adjustments in cuticle traits resulting from acclimation or adaptation to different habitats remains poorly understood. Here, we used genetically well‐characterised populations of Arabidopsis arenosa to investigate whether cuticle ...
Clara Bertel, Erwann Arc, Magdalena Bohutínská, Dominik Kaplenig, Julian Maindok, Elisa La Regina, Guillaume Wos, Filip Kolář, Karl Hülber, Werner Kofler, Gilbert Neuner, Ilse Kranner   +11 more
wiley   +1 more source

The role of biotransformation processes in mediating interactions between psychotropic drugs and natural products [PDF]

, 2020
Many patients are not aware that natural products such as fruit juices or plant infusions can cause significant interactions with several drugs, some of which can be dangerous, especially when the medical treatment is for neurological or psychiatric ...
Bacinschi, Nicolae, Chianu, Marin, Mihalachi-Anghel, Maria, Podgurschi, Lilia, Pogonea, Ina, Socea, Bogdan, Ștefănescu, Emil   +6 more
core   +1 more source

Combined enhancement of ascorbic acid, β‐carotene and zeaxanthin in gene‐edited lettuce

Plant Biotechnology Journal, EarlyView.
Summary Lettuce is widely grown and consumed but provides lower nutritional value compared to other leafy greens, particularly in the essential vitamins A and C. To address this, major control points in carotenoid and ascorbic acid (AsA) production were targeted using a viral‐based CRISPR/Cas9 system in the commercial lettuce cultivar ‘Noga’.
Yarin Livneh, Ehud Leor‐Librach, Dor Agmon, Tal Makov‐Bouaniche, Vivekanand Tiwari, Ekaterina Shor, Yelena Yeselson, Tania Masci, Arthur Schaffer, Dana Charuvi, Joseph Hirschberg, Alexander Vainstein   +11 more
wiley   +1 more source

Mother knows worst? Fungal infection enhances corn flavonoid of wogonin to inhibit Conogethes punctiferalis larval growth

Plant Biotechnology Journal, EarlyView.
Schematic representation of Trichoderma asperellum infection affects the flavonoid content in corn and influences the gut microbiota and juvenile hormone pathway of Conogethes punctiferalis larvae leading to growth inhibition. Summary Pathogen infection in host plants can alter the attraction and adaptability of herbivorous insects.
Qian Li, Jiayu Li, Kaining Wu, Yue Tong, Aihuan Zhang, Yanli Du   +5 more
wiley   +1 more source