Results 91 to 100 of about 35,768 (229)

Pharmacokinetics and Safety Evaluation of a New Generic Sitafloxacin: A Phase I Bioequivalence Study in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, Volume 14, Issue 8, Page 592-597, August 2025.
Abstract Sitafloxacin is a new antibiotic drug belonging to the fourth generation quinolone antibiotics. The aim of this study was to evaluate the pharmacokinetics (PK), safety profiles, and bioequivalence of test and reference 50‐mg sitafloxacin tablets under fasting and fed conditions.
Yongfang Lei, Pan Luo, Yuzhu Chen, Liuliang Xue, Donglin Zhang, Xingxing Qi, Yinian Fang, Hengyi Yu, Zheng He, Qin Zuo, Chang Liu, Dong Liu, Xinhua Ren, Qian Chen   +13 more
wiley   +1 more source

Effect of Mild to Moderate Hepatic Impairment on Valemetostat Pharmacokinetics: An Open‐Label, Phase I Study

Clinical Pharmacology in Drug Development, Volume 14, Issue 8, Page 631-641, August 2025.
Abstract Valemetostat tosylate (valemetostat) is a dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1, approved in Japan for the treatment of relapsed/refractory peripheral T‐cell lymphoma and adult T‐cell leukemia/lymphoma. This Phase I, open‐label study evaluated the pharmacokinetics and safety of a single 50‐mg oral dose of valemetostat in
Masaya Tachibana, Thuy Vu Craveiro, Thomas C. Marbury, Samuel Oberstein, George J. Atiee, Ben Tao, Takako Shimizu, Yvonne Lau, Malaz A. Abutarif   +8 more
wiley   +1 more source

Prevalence of Actionable Pharmacogenetic Genotype Frequencies, Cautionary Medication Use, and Polypharmacy in Community‐Dwelling Older Adults

Clinical Pharmacology &Therapeutics, Volume 118, Issue 2, Page 337-342, August 2025.
Older adults (65 years and over) frequently manage complex medication regimens and are vulnerable to adverse drug reactions and treatment inefficacies, some of which could be preventable with pharmacogenetics (PGx)‐guided prescribing. This study examined the prevalence of actionable PGx genotypes (i.e., those linked to a guideline that recommends a ...
Chad A. Bousman, Ankita Narang, Ziad Al Bkhetan, Robyn L. Woods, Suzanne G. Orchard, Alice J. Owen, Michelle A. Fravel, Julia Gilmartin‐Thomas, Joanne Ryan, Peter D. Fransquet, Rory Wolfe, Chenglong Yu, John J. McNeil, Paul Lacaze, Michael E. Ernst   +14 more
wiley   +1 more source

Screening of Theaflavins That Inhibit Proliferation of Nasopharyngeal Carcinoma Cells Through Metabolomics Approaches

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
This study investigated the effects of theaflavin‐3,3′‐digallate (TF3) markedly suppresses the proliferation, migration, invasion of nasopharyngeal carcinoma cells while promoting apoptosis in a dose‐dependent manner. Metabolomic profiling identified 584 altered metabolites, revealing key disruptions in ABC transporter activity and amino acid ...
Chunpeng Wan, Xiaomeng Hu, Puxiang Yang, Mingxi Li, Muhammad Farrukh Nisar, Zihao Zhou, Yudi Gan, Yi Cai, Zhonghua Liu   +8 more
wiley   +1 more source

Torreya grandis Seed Polyphenols Protect RAW264.7 Macrophages by Inhibiting Oxidative Stress and Inflammation

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Torreya grandis seed polyphenols (TGSP), primarily containing gallic acid and epicatechin, exhibit selective free radical scavenging activity. TGSP pretreatment effectively inhibits LPS‐induced inflammatory responses by reducing TNF‐α, NO, and IL‐6 production. TGSP also alleviates H2O2‐induced oxidative stress by enhancing antioxidant enzyme activities
Ran Liu, Baogang Zhou, Kundian Che, Wei Gao, Haoyuan Luo, Jialin Yang, Zhanjun Chen, Wenzhong Hu   +7 more
wiley   +1 more source

Dietary Carvacrol Attenuates Cyclophosphamide‐Induced Neurotoxicity: Implications for Food‐Derived Neuroprotection and Molecular Mechanisms

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Carvacrol, a compound found in herbs like oregano and thyme, shows promise in protecting against cyclophosphamide‐induced neurotoxicity in rats by reducing oxidative stress, inflammation, and cell death, and by preserving cognitive function. ABSTRACT Carvacrol (CRV) is a phenolic monoterpene abundant in culinary herbs such as oregano and thyme and is ...
Hamit Emre Kızıl
wiley   +1 more source

Phytochemical Profiling, Antioxidant Capacity, and the Antidiabetic Potential of Atriplex halimus Extracts: UHPLC–MS/MS Analysis, In Vitro Enzyme Inhibition Assays, and Molecular Docking Studies

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Atriplex halimus extracts exhibited significant antidiabetic activity, notably inhibiting α‐amylase and hemoglobin glycation. UHPLC‐MS/MS analysis identified 21 phytochemicals, with trans‐cinnamic acid being the most abundant. Molecular docking revealed catechin and epigallocatechin as key bioactive compounds with strong binding affinities, surpassing ...
Mohammed Roubi, Nour Elhouda Daoudi, Mohammed Dalli, Salah‐eddine Azizi, Youness Mahdi, Ramzi A. Mothana, Hanan M. Al‐Yousef, Mohammed F. Hawwal, Fahd Kandsi, Raffaele Conte, Nadia Gseyra   +10 more
wiley   +1 more source

Studies on the rate-limiting enzyme component in the microsomal monooxygenase system. Incorporation of purified NADPH-cytochrome c reductase and cytochrome P-450 into rat liver microsomes.

, 1978
Gerald T. Miwa, S.B. West, Albert Lu
openalex   +1 more source

Allergenicity, Genotoxicity and Subchronic Toxicity Assessment of IgG Binding Protein LT Produced From Aspergillus oryzae

Journal of Applied Toxicology, Volume 45, Issue 8, Page 1614-1636, August 2025.
ABSTRACT Gastrointestinal health is one of the fastest growing areas in the food and beverage industry, as its importance to overall health and well‐being is becoming increasingly recognized. Immunoglobulins play a key role in protecting the gastrointestinal tract, and nonbovine sources of immunoglobulins (including camel milk, which has a long history
Kirt R. Phipps, Sachin Patel, Kevin Scaife, Toby Holmes, Alica Šoltésová, Sandra Wingaard Thrane, Louise Kristine Vigsnæs, Nigel Baldwin, Christel Jørgensen   +8 more
wiley   +1 more source

1,8‐Cineole Protects Against Liver Toxicity Induced by Aroclor‐1254 in a Rat Model

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 8, August 2025.
This study aimed to determine the protective role of 1,8‐cineol in Aroclor‐1254 induced liver toxicity in a rat model. 1,8‐cineol may be a protective agent due to its anti‐apoptotic effect, reduction of oxidative damage, anti‐inflammatory efficacy, and amelioration of histopathological changes in liver toxicity. ABSTRACT This study aimed to demonstrate
Hadiqa Arshad, Muhammed Fatih Doğan, Münevver Nazlıcan Zengin, Özlem Özmen, Osman Çiftçi   +4 more
wiley   +1 more source