Enzyme Mimic Displaying Oscillatory Behavior. Oscillating Reduction of Manganese(III) Porphyrin in a Membrane-Bound Cytochrome P-450 Model System [PDF]
Contains fulltext : 10134.pdf (Publisher’s version ) (Open Access)
Albertus P. H. J. Schenning+5 more
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Hydroxyl radical-mediated, cytochrome P-450-dependent metabolic activation of benzene in microsomes and reconstituted enzyme systems from rabbit liver. [PDF]
The mechanism of benzene oxygenation in liver microsomes and in reconstituted enzyme systems from rabbit liver was investigated. It was found that the NADPH-dependent transformation of benzene to water-soluble metabolites and to phenol catalyzed by cytochrome P-450 LM2 in membrane vesicles was inhibited by catalase, horseradish peroxidase, superoxide ...
Inger Johansson+1 more
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Flavonoids and Furanocoumarins Involved in Drug Interactions [PDF]
Drug interactions can have significant consequences for public health, especially given the growing importance of readily available dietary supplements.
Sabine Berteina-Raboin
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Kinetic studies of the N-demethylation of ethylmorphine by a cytochrome P-450-dependent enzyme system in human liver microsomes [PDF]
S S Thorgeirsson, D. S. Davies
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Fatal poisoning case involving drug interaction due to the inhibition of cytochrome P450 [PDF]
Introduction. Cytochrome P450 (CYP) enzymes are responsible for the metabolism of various drugs and chemicals. The forensic pathologist should consider not only pharmacodynamic interactions by multiple drugs but also the pharmacokinetic drug interactions
Kinoshita Hiroshi+6 more
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CHANGE IN INTESTINAL FLORA AND ITS ASSOCIATION WITH LIVER CYP2E1 IN MICE WITH LIVER INJURY INDUCED BY HIGH-INTENSITY ATORVASTATIN [PDF]
Objective To investigate the change in intestinal flora and its association with liver CYP2E1 in mice with li-ver injury caused by high-intensity atorvastatin (ATO).
SONG Bingxue, SONG Yuqing, LIU Xin, YU Haichu, XIN Hui, LIANG Hui
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A child with Kawasaki disease and genetic warfarin sensitivity from CYP2C9 and VKORC1 gene variants [PDF]
Kawasaki disease (KD) is a common febrile disease in East Asia. Because KD with coronary artery aneurysm (CAA) may predispose to thrombosis, children with KD-associated CAA may need anticoagulation in addition to aspirin.
Myeongseob Lee, Lucy Youngmin Eun
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The Blind Spot of Pharmacology: A Scoping Review of Drug Metabolism in Prematurely Born Children
The limit for possible survival after extremely preterm birth has steadily improved and consequently, more premature neonates with increasingly lower gestational age at birth now require care. This specialized care often include intensive pharmacological
Mette Louise Mørk+3 more
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Paclitaxel is a prescribed anticancer drug used to treat various cancers. It is a substrate of cytochrome P-450 (CYP-450) enzymes. Despite its efficacy, paclitaxel has severe side effects.
Alinafe Magret Kapelemera+13 more
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