Results 11 to 20 of about 778,835 (257)
Enzyme Mimic Displaying Oscillatory Behavior. Oscillating Reduction of Manganese(III) Porphyrin in a Membrane-Bound Cytochrome P-450 Model System [PDF]
Journal of the American Chemical Society, 1995 Contains fulltext : 10134.pdf (Publisher’s version ) (Open Access)
Albertus P. H. J. Schenning +5 more
openalex +5 more sources
Hydroxyl radical-mediated, cytochrome P-450-dependent metabolic activation of benzene in microsomes and reconstituted enzyme systems from rabbit liver. [PDF]
Journal of Biological Chemistry, 1983 The mechanism of benzene oxygenation in liver microsomes and in reconstituted enzyme systems from rabbit liver was investigated. It was found that the NADPH-dependent transformation of benzene to water-soluble metabolites and to phenol catalyzed by cytochrome P-450 LM2 in membrane vesicles was inhibited by catalase, horseradish peroxidase, superoxide ...
Inger Johansson +1 more
openalex +3 more sources
Kinetic studies of the N-demethylation of ethylmorphine by a cytochrome P-450-dependent enzyme system in human liver microsomes [PDF]
Biochemical Journal, 1971 S S Thorgeirsson, D. S. Davies
openalex +4 more sources
The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis
Angewandte Chemie International Edition, Volume 62, Issue 3, January 16, 2023., 2023 The cytochrome P450 enzyme AbyV catalyses a key epoxidation in the final stages of the biosynthesis of the spirotetronate antibiotic abyssomicin C. Combining structural and computational data with a 13C labelling strategy was found to be a powerful approach to interrogate the biotransformation and determine the precise function of the enzyme.
Andrew J. Devine +13 more
wiley +1 more source
Chemistry – A European Journal, Volume 28, Issue 67, December 1, 2022., 2022 Structural and biochemical data demonstrate that 4‐phenylbenzoic acid binds within the active site of the cytochrome P450 monooxygenase CYP199A4, but no oxidation occurs. Protein engineering and molecular dynamic simulations establish that aromatic oxidation is enabled by a subtle shift of the substrate relative to the heme, thus improving our ...
Tom Coleman +9 more
wiley +1 more source
Functional activity of peptide ion channels in tethered bilayer lipid membranes: Review
Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022 Abstract Ion transport across biomembranes plays a major role in living cells. This fundamental function is normally carried out by molecules with both a hydrophobic and a hydrophilic side (amphiphilic molecules), which aggregate within the membrane forming a hydrophilic pore (the ion channel) permitting the selective translocation of permeant ions ...
Rolando Guidelli, Lucia Becucci
wiley +1 more source
Food Science &Nutrition, Volume 11, Issue 1, Page 261-273, January 2023., 2023 Five obtained peptides exhibited high radical scavenging activities in the following order: F5 > F3 > F1 > F2 > F4.; F5 has the highest activities for DPPH‐IC50 was 21.75 μg/mL, hydroxyl‐IC50 was 18.75 μg/mL, and Superoxide‐IC50 was 11.00 μg/mL and the reducing power was 2.54 OD700.; F5 had the highest antioxidant activity and not only prevented the ...
Hui Huang +9 more
wiley +1 more source
International Journal of Cancer, Volume 152, Issue 5, Page 879-912, 1 March 2023., 2023 Abstract Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature.
Haleigh Cavalier +2 more
wiley +1 more source