Results 11 to 20 of about 35,768 (229)

Enzyme Mimic Displaying Oscillatory Behavior. Oscillating Reduction of Manganese(III) Porphyrin in a Membrane-Bound Cytochrome P-450 Model System [PDF]

open access: greenJournal of the American Chemical Society, 1995
Contains fulltext : 10134.pdf (Publisher’s version ) (Open Access)
Albertus P. H. J. Schenning   +5 more
openalex   +5 more sources

Hydroxyl radical-mediated, cytochrome P-450-dependent metabolic activation of benzene in microsomes and reconstituted enzyme systems from rabbit liver. [PDF]

open access: hybridJournal of Biological Chemistry, 1983
The mechanism of benzene oxygenation in liver microsomes and in reconstituted enzyme systems from rabbit liver was investigated. It was found that the NADPH-dependent transformation of benzene to water-soluble metabolites and to phenol catalyzed by cytochrome P-450 LM2 in membrane vesicles was inhibited by catalase, horseradish peroxidase, superoxide ...
Inger Johansson   +1 more
openalex   +3 more sources

Flavonoids and Furanocoumarins Involved in Drug Interactions [PDF]

open access: yesMolecules
Drug interactions can have significant consequences for public health, especially given the growing importance of readily available dietary supplements.
Sabine Berteina-Raboin
doaj   +2 more sources

Fatal poisoning case involving drug interaction due to the inhibition of cytochrome P450 [PDF]

open access: yesVojnosanitetski Pregled, 2021
Introduction. Cytochrome P450 (CYP) enzymes are responsible for the metabolism of various drugs and chemicals. The forensic pathologist should consider not only pharmacodynamic interactions by multiple drugs but also the pharmacokinetic drug interactions
Kinoshita Hiroshi   +6 more
doaj   +1 more source

CHANGE IN INTESTINAL FLORA AND ITS ASSOCIATION WITH LIVER CYP2E1 IN MICE WITH LIVER INJURY INDUCED BY HIGH-INTENSITY ATORVASTATIN [PDF]

open access: yes精准医学杂志, 2023
Objective To investigate the change in intestinal flora and its association with liver CYP2E1 in mice with li-ver injury caused by high-intensity atorvastatin (ATO).
SONG Bingxue, SONG Yuqing, LIU Xin, YU Haichu, XIN Hui, LIANG Hui
doaj   +1 more source

A child with Kawasaki disease and genetic warfarin sensitivity from CYP2C9 and VKORC1 gene variants [PDF]

open access: yesPediatric Emergency Medicine Journal, 2020
Kawasaki disease (KD) is a common febrile disease in East Asia. Because KD with coronary artery aneurysm (CAA) may predispose to thrombosis, children with KD-associated CAA may need anticoagulation in addition to aspirin.
Myeongseob Lee, Lucy Youngmin Eun
doaj   +1 more source

The Blind Spot of Pharmacology: A Scoping Review of Drug Metabolism in Prematurely Born Children

open access: yesFrontiers in Pharmacology, 2022
The limit for possible survival after extremely preterm birth has steadily improved and consequently, more premature neonates with increasingly lower gestational age at birth now require care. This specialized care often include intensive pharmacological
Mette Louise Mørk   +3 more
doaj   +1 more source

Pharmacokinetic Herb-Drug Interactions of Xiang-Sha-Liu-Jun-Zi-Tang and Paclitaxel in Male Sprague Dawley Rats and Its Influence on Enzyme Kinetics in Human Liver Microsomes

open access: yesFrontiers in Pharmacology, 2022
Paclitaxel is a prescribed anticancer drug used to treat various cancers. It is a substrate of cytochrome P-450 (CYP-450) enzymes. Despite its efficacy, paclitaxel has severe side effects.
Alinafe Magret Kapelemera   +13 more
doaj   +1 more source

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