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Inhalation of Butanols: Changes in the Cytochrome P-450 Enzyme System
1985After inhalation of different butanol isomers for 3 days (2000 ppm) and 5 days (500 ppm), liver and kidney parameters of the microsomal cytochrome P-450 enzyme system were increased. sec-Butanol caused the highest increase in cytochrome P-450 concentration with a 47% rise in the kidneys (500 ppm for 5 days) and 33% in the liver (2000 ppm for 3 days). A
Kjell Aarstad +2 more
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Enzyme, 1982
The rate of oxidative demethylation of ethylmorphine by preparations of microsomes from livers of male rats decreased following whole-body gamma-irradiation, reaching a minimum of 50% of the control value on the 5th or 6th day. The value of apparent Vmax changed markedly after irradiation when the Km value was unaltered. At the same time, the amount of
Zajac Jm, Bernard P
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The rate of oxidative demethylation of ethylmorphine by preparations of microsomes from livers of male rats decreased following whole-body gamma-irradiation, reaching a minimum of 50% of the control value on the 5th or 6th day. The value of apparent Vmax changed markedly after irradiation when the Km value was unaltered. At the same time, the amount of
Zajac Jm, Bernard P
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Enzyme induction in the cytochrome P-450 system
Pharmacology & Therapeutics, 1990Article de synthese traitant de l'induction enzymatique du cytochrome P450 du rat. Extension a une etude interspecifique.
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Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1987
N,N-Dimethylaniline when added to reaction mixtures provokes deviation from Michaelis-Menten law of the interaction kinetics of NADPH-cytochrome c(P-450) reductase (NADPH:ferrihaemoprotein oxidoreductase, EC 1.6.2.4) with highly purified phenobarbital-induced rabbit liver microsomal cytochrome P-450 (P-450LM2).
Peter Hlavica, Ines Golly, Jutta Wolf
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N,N-Dimethylaniline when added to reaction mixtures provokes deviation from Michaelis-Menten law of the interaction kinetics of NADPH-cytochrome c(P-450) reductase (NADPH:ferrihaemoprotein oxidoreductase, EC 1.6.2.4) with highly purified phenobarbital-induced rabbit liver microsomal cytochrome P-450 (P-450LM2).
Peter Hlavica, Ines Golly, Jutta Wolf
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NADPH reduction of cytochrome P-450 at different integrational levels of the enzyme system
1979The complex monooxygenatic enzyme exhibits different functional behaviour at different integrational levels, thus indicating distinct organizational states. The aerobic NADPH reduction of microsomes, solubilized and reconstituted systems follows a biphasic kinetics, the two phases are attributed to associated state (cluster) and random cytochrome P-450
J, Blanck +5 more
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Analytica Chimica Acta, 1991
Abstract A number of staining techniques on Western blots were compared with respect to sensitivity, background staining and practical applicability. After electrophoresis of a rat microsomal preparation, followed by blotting and incubation of a primary antibody against a purified cytochrome P-450 fraction, enzyme-labelled second antibodies were used
Erna J.M. Reinerink +3 more
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Abstract A number of staining techniques on Western blots were compared with respect to sensitivity, background staining and practical applicability. After electrophoresis of a rat microsomal preparation, followed by blotting and incubation of a primary antibody against a purified cytochrome P-450 fraction, enzyme-labelled second antibodies were used
Erna J.M. Reinerink +3 more
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The Journal of Biochemistry, 1985
The cell-free extract of a cytochrome P-450-producing fungus, Fusarium oxysporum, was found to catalyze the hydroxylation of fatty acids. Three product isomers were formed from a single fatty acid. The products from lauric acid were identified by mass-spectrometry as 9-, 10-, and 11-hydroxydodecanoic acids, and those from palmitic acid as 13-, 14-, and
Teruhiko Beppu +2 more
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The cell-free extract of a cytochrome P-450-producing fungus, Fusarium oxysporum, was found to catalyze the hydroxylation of fatty acids. Three product isomers were formed from a single fatty acid. The products from lauric acid were identified by mass-spectrometry as 9-, 10-, and 11-hydroxydodecanoic acids, and those from palmitic acid as 13-, 14-, and
Teruhiko Beppu +2 more
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Digestive Diseases and Sciences, 1991
Interactions with the hepatic cytochrome P-450 microsomal enzyme system, as evidenced by statistically significant changes in pharmacokinetic parameters, have been described with some H2-receptor antagonists. Omeprazole is the first of a new class of antisecretory agents inhibiting gastric secretion by blocking hydrogen potassium ATPase.
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Interactions with the hepatic cytochrome P-450 microsomal enzyme system, as evidenced by statistically significant changes in pharmacokinetic parameters, have been described with some H2-receptor antagonists. Omeprazole is the first of a new class of antisecretory agents inhibiting gastric secretion by blocking hydrogen potassium ATPase.
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