Results 211 to 220 of about 778,835 (257)
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Pesticide induced changes in the mouse hepatic microsomal cytochrome P‐450‐dependent monooxygenase system and other enzymes

Journal of Environmental Science and Health, Part B, 1981
Livers of mice previously treated with potential inducers were tested for effects on the microsomal cytochrome P-450-dependent monooxygenase system (including its constituent electron transport enzymes) and other enzymes. Microsomes were also examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Karen M. Robacker   +2 more
openaire   +3 more sources

Biomonitoring of pollution: the hepatic cytochrome P-450 enzyme system in the feral mouse Apodemus flavicollis as indicator

Chemosphere, 1994
Abstract The aim of the present study was to find a suitable wild-rodent to be used as terrestrial bioindicator. The wild mice were trapped at three sites around Vienna and at a fourth location in the countryside. Apodemus flavicollis , the yellow-necked mouse, was the most frequently captured mouse at all four sites.
Friedrich Tobil   +4 more
openaire   +2 more sources

Interaction of mineral fibres with lung cytochrome P-450 system: Impairment of drug metabolizing enzyme activities

Chemosphere, 1992
Abstract In the present study, in vitro effects of carcinogenic (chrysotile, crocidolite, amosite) and non-carcinogenic (anthophyllite) varieties of asbestos and three varieties of Indian wollastonite (kemolit A-60, Kemolit-N, Kemolit ASB-3) boTh on phase I and phase Ii drug metabolizing enzymes and microsomal lipid peroxidatin (LPO) in rat lung were
Sikandar G. Khan   +2 more
openaire   +2 more sources

Enzymatic detoxication of DDT to DDD by rat liver: Effects of some inducers and inhibitors of cytochrome P-450 enzyme system

Bulletin of Environmental Contamination and Toxicology, 1987
DDT, in very first step of its detoxication is either transformed to DDD by reductive dechlorination (Walker i969; Hassal 1973) or DDE by dehydrochlorination (Datta 1970). For further detoxication, these metabolites undergo a series of reactions which result in the elimination of DDA in urine (Peterson and Robison 1964; Datta 1970; Gold and Brunk 1982).
S. S. A. Zaidi, B. D. Banerjee
openaire   +3 more sources

Demethylation of tertiary amines by a reconstituted cytochrome P-450 enzyme system: Kinetics of oxygen consumption and hydrogen peroxide formation

Journal of Inorganic Biochemistry, 1989
Initial reaction rates of oxygen consumption and hydrogen peroxide formation in a cytochrome P-450 catalyzed reaction are practically independent of the nature of tertiary amines that were used as substrates. From the kinetic studies and the substrate conversion results that the amount of water formed in a side reaction is determined by the substrate ...
Ruckpaul K   +3 more
openaire   +3 more sources

A Spin Trap Study on Anaerobic Dehalogenation of Halothane by a Reconstituted Liver Microsomal Cytochrome P.450 Enzyme System1

The Journal of Biochemistry, 1982
In the presence of a spin trapping reagent, N-tert-butyl-alpha-phenylnitrone, anaerobic incubation of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) with a reconstituted cytochrome P-450 enzyme system of rabbit liver microsomes exhibited an electron spin resonance spectrum containing signals of a nitroxide radical, and all components of the ...
Masaru Kanashiro   +7 more
openaire   +3 more sources

Regiochemical Variations in Reactions of Methylcubane with tert-Butoxyl Radical, Cytochrome P-450 Enzymes, and a Methane Monooxygenase System

Journal of the American Chemical Society, 1996
Reactions of methylcubane (1) with the tert-butoxyl radical (t-BuO•), with cytochrome P-450 enzymes, and with a methane monooxygenase (MMO) system have been studied.
Stephen J. Lippard   +8 more
openaire   +2 more sources

Brain and other central nervous system tumor statistics, 2021

Ca-A Cancer Journal for Clinicians, 2021
Carol Kruchko   +2 more
exaly  

[Effect of induction of enzymes of the cytochrome p-450 system on the survival of rats after acute hemorrhage].

Patologicheskaia fiziologiia i eksperimental'naia terapiia, 1996
The effect of acute hemorrhage on the functional status of microsomal cytochrome P-450-dependent hepatic monoxygenases and the impact of induction of these monoxygenases on the survival of posthemorrhagic male Wistar rats. Acute blood loss of the rats, which caused 50% deaths led approximately to a double decrease in the hepatic activity of 77 ...
E I, Astashkin   +2 more
openaire   +1 more source

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