Results 211 to 220 of about 104,306 (283)

Exploring the roles of cytochrome P450 enzymes and their inhibitors in cancers and non-neoplastic human diseases. [PDF]

Arch Pharm Res
Lee H, Kwon YJ, Chun YJ.
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Transcription factors of the Nuclear Factor I (NFI) family control hepatocyte differentiation and cytochrome P450 activity in human liver.

Pharmacol Res
Klein K, Burk O, Tremmel R, Buettner FA, Kaestle L, Schroth W, Muerdter TE, Eccles D, Schmidt AC, Nieß H, Zanger UM, Schwab M, Lauschke VM.   +12 more
europepmc   +1 more source

A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11. [PDF]

Biochem J
Davydov DR, Ponraj K, Davydova N, Singh DK, Prasad B.   +4 more
europepmc   +1 more source

A synthesis of 1β-hydroxytestosterone, a metabolite of xenobiotic human cytochrome P450 enzymes, beginning with a borylation of boldione.

Org Biomol Chem
Elizondo AI, McCarty KD, Arman HD, Guengerich FP, Yoshimoto FK.   +4 more
europepmc   +1 more source

Enzyme induction in the cytochrome P-450 system

Pharmacology & Therapeutics, 1990
Article de synthese traitant de l'induction enzymatique du cytochrome P450 du rat. Extension a une etude interspecifique.
Allan B. Okey
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Influence of N,N-dimethylaniline on the association of phenobarbital-induced cytochrome P-450 and NADPH-cytochrome c(P-450) reductase in a reconstituted rabbit liver microsomal enzyme system

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1987
N,N-Dimethylaniline when added to reaction mixtures provokes deviation from Michaelis-Menten law of the interaction kinetics of NADPH-cytochrome c(P-450) reductase (NADPH:ferrihaemoprotein oxidoreductase, EC 1.6.2.4) with highly purified phenobarbital-induced rabbit liver microsomal cytochrome P-450 (P-450LM2).
Peter Hlavica, Ines Golly, Jutta Wolf
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Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole

Digestive Diseases and Sciences, 1991
Interactions with the hepatic cytochrome P-450 microsomal enzyme system, as evidenced by statistically significant changes in pharmacokinetic parameters, have been described with some H2-receptor antagonists. Omeprazole is the first of a new class of antisecretory agents inhibiting gastric secretion by blocking hydrogen potassium ATPase.
Thomas J. Humphries
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CHARACTERIZATION OF A RECONSTITUTED CYTOCHROME P-450 ENZYME SYSTEM MEDIATING TERTIARY AMINE N-OXIDATION

, 1980
Publisher Summary This chapter focuses on characterization of a reconstituted cytochrome P-450 enzyme system mediating tertiary amine N-oxidation. Evidence is presented for the ability of a reconstituted system containing highly purified cytochrome P-448, NADPH-cytochrome c reductase, and lipid factor to mediate N-oxidation of N,N-dimethylaniline. In
Peter Hlavica, S. Hülsmann
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Pesticide induced changes in the mouse hepatic microsomal cytochrome P‐450‐dependent monooxygenase system and other enzymes

Journal of Environmental Science and Health, Part B, 1981
Livers of mice previously treated with potential inducers were tested for effects on the microsomal cytochrome P-450-dependent monooxygenase system (including its constituent electron transport enzymes) and other enzymes. Microsomes were also examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Karen M. Robacker, Arun P. Kulkarni, Ernest Hodgson   +2 more
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Interaction of mineral fibres with lung cytochrome P-450 system: Impairment of drug metabolizing enzyme activities

Chemosphere, 1992
Abstract In the present study, in vitro effects of carcinogenic (chrysotile, crocidolite, amosite) and non-carcinogenic (anthophyllite) varieties of asbestos and three varieties of Indian wollastonite (kemolit A-60, Kemolit-N, Kemolit ASB-3) boTh on phase I and phase Ii drug metabolizing enzymes and microsomal lipid peroxidatin (LPO) in rat lung were
Sikandar G. Khan, Shahid Ali, Q. Rahman
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