Results 61 to 70 of about 778,835 (257)

Bifunctional enzyme provides absolute concentration robustness in multisite covalent modification networks [PDF]

arXiv, 2023
Biochemical covalent modification networks exhibit a remarkable suite of steady state and dynamical properties such as multistationarity, oscillations, ultrasensitivity and absolute concentration robustness. This paper focuses on conditions required for a network to have a species with absolute concentration robustness. We find that the robustness in a
arxiv  

Influence of a 2nd Sphere Hydrogen‐Bond Donor on the Reactivity of Non‐heme Fe(II) Complexes in Alkane, Alkene and Aromatic Oxidation with H2O2

Chemistry – A European Journal, EarlyView.
Addition of a 2nd sphere hydrogen bond donor in iron complexes induces the selection of a specific FeIIIOOH species in the presence of H2O2 thanks to the stabilizing H‐bonding interaction with the proximal O. This structural pattern, after OO bond cleavage, enhances the electrophilicity of the resulting high valent oxo species, which improves ...
Amanda Lyn Robinson, Eva Bannerman, Marika Di Berto Mancini, Wesley R. Browne, Régis Guillot, Christian Herrero, Tanya Inceoglu, Hélène Maisonneuve, Frédéric Banse, Jean‐Noël Rebilly   +9 more
wiley   +1 more source

Comparison of Cholesterol Lowering Diets: Apple, Casein Cytochrom P450 protein and Cholesterol 7α Hydroxylase Activities in Hamsters [PDF]

, 2010
Lithogenic diet, casein and apple fiber diets were fed to hamsters for 3-5 weeks. For control group, animals were fed on normal Purina chow without any supplement.
Rakesh Sharma, Rakesh K. Tandon
core   +2 more sources

Exploring Bonding in Bioinorganic Chemistry: Ab Initio Valence Bond Calculations of Iron(II)‐CO and Iron(IV)‐Oxo Units in Cytochrome P450 under Oriented External Electric Fields

Chemistry–Methods, EarlyView.
Ab initio valence bond calculations under oriented electric fields along the bond axis of Fe(II)‐CO and Fe(IV)‐oxo units in cytochrome P450 enzymes highlight their effectiveness in probing complex bonding characteristics and ligand effects in bioinorganic systems.
Enhua Zhang, Hajime Hirao
wiley   +1 more source

Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective [PDF]

, 2019
Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism.
Croubels, Siska, De Clerck, Laura, Deforce, Dieter, Devreese, Mathias, Govaert, Elisabeth, Millecam, Joske, Schelstraete, Wim, Van Bocxlaer, Jan   +7 more
core   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

In Vivo Evolution of Butane Oxidation by Terminal Alkane Hydroxylases AlkB and CYP153A6 [PDF]

, 2009
Enzymes of the AlkB and CYP153 families catalyze the first step in the catabolism of medium-chain-length alkanes, selective oxidation of the alkane to the 1-alkanol, and enable their host organisms to utilize alkanes as carbon sources.
Arnold, Frances H., Chen, Mike M., Koch, Daniel J., van Beilen, Jan B.   +3 more
core   +3 more sources

Structural Characterization, Phenolic Acid Modification, and Antioxidant Activities of Polysaccharide From Mogroside Waste Liquid of Siraitia grosvenorii

Food Frontiers, EarlyView.
ABSTRACT To improve the comprehensive utilization of Siraitia grosvenorii (Swingle) C. Jeffrey, a novel polysaccharide (SGP) was isolated from the mogroside waste liquid of S. grosvenorii. In addition, ferulic acid–SGP (FA‐SGP) and caffeic acid–SGP (CA‐SGP) were prepared by modifying SGP with phenolic acid.
Jiajing Duan, Yufeng Sun, Bo Wang, Qinfei Xie, Yang Ju, Fengzhong Wang, Bei Fan   +6 more
wiley   +1 more source

The evolution and structure of biomedical knowledge on cytochrome P450 [PDF]

arXiv, 2017
Cytochrome P450 are fundamental proteins to the metabolism of drugs and other relevant processes. through a combination of text mining and network analysis of the P450 literature we mapped the emergence and evolution of the biomedical research communities working on this family of proteins.
arxiv  

Redox and Chemical Activities of the Hemes in the Sulfur Oxidation Pathway Enzyme SoxAX [PDF]

, 2012
BACKGROUND: SoxAX enzymes initiate microbial oxidation of reduced inorganic sulfur compounds. Their catalytic mechanism is unknown. RESULTS: Cyanide displaces the CysS(-) ligand to the active site heme following reduction by S(2)O(4)(2-) but not Eu(II ...
Anderson, Appia-Ayme, Astuti, Bamford, Bordo, Cheesman, Cheesman, Dambe, Dhawan, Du, Friedrich, Frigaard, Gadsby, Gliubich, Kappler, Kappler, Kappler, Keen, Kemp, Kilmartin, Male, Marritt, Marritt, McKnight, Mishra, Ogawa, Ostergaard, Perera, Quentmeier, Reijerse, Sauvé, Shaw, Simon, Sono, Vincent, Walker, Weaver, Yoshioka   +37 more
core   +1 more source