Results 81 to 90 of about 778,835 (257)
Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame. [PDF]
, 2016 The endoplasmic reticulum (ER)-anchored hepatic cytochromes P450 (P450s) are enzymes that metabolize endo- and xenobiotics i.e. drugs, carcinogens, toxins, natural and chemical products.
Correia, Maria Almira +4 more
core +1 more source
Comparative Proteomics of Salinity Stress Responses in Fish and Aquatic Invertebrates
PROTEOMICS, EarlyView.ABSTRACT Fluctuating salinity is symptomatic of climate change challenging aquatic species. The melting of polar ice, rising sea levels, coastal surface and groundwater salinization, and increased evaporation in arid habitats alter salinity worldwide. Moreover, the frequency and intensity of extreme weather events such as rainstorms and floods increase,
Maxime Leprêtre +3 more
wiley +1 more source
Structures, Functions, and Mechanisms of Filament Forming Enzymes: A Renaissance of Enzyme Filamentation [PDF]
arXiv, 2019 Filament formation by non-cytoskeletal enzymes has been known for decades, yet only relatively recently has its wide-spread role in enzyme regulation and biology come to be appreciated. This comprehensive review summarizes what is known for each enzyme confirmed to form filamentous structures in vitro, and for the many that are known only to form large
arxiv
Comparison of different approaches to single-molecule imaging of enhanced enzyme diffusion [PDF]
arXiv, 2020 Enzymes have been shown to diffuse faster in the presence of their reactants. Recently, we revealed new insights into this process of enhanced diffusion using single-particle tracking (SPT) with total internal reflection fluorescence (TIRF) microscopy.
arxiv
The Role of Insulin and Growth Hormone in the Regulation of Hepatic Steroid Metabolism [PDF]
, 1989 The hepatic monooxygenase system catalyses the oxidative metabolism of both endogenous steroids and xenobiotics, and consists of three main components : cytochrome P-450, NADPH cytochrome P-450 reductase and lipid (reviewed by Skett 1987).
Gulati, Poonam
core
Phytotherapy Research, EarlyView.This study suggests that maslinic acid treatment protected intestinal mucosa and ameliorated gut inflammation, accompanied with significantly reduced inflammatory cytokines and Th cell infiltration and subset differentiation. In vitro, maslinic acid suppressed Th cell proliferation and differentiation, regulated cell cycle distribution, and decreased ...
Dan Li +8 more
wiley +1 more source
Molecular biomarkers and toxic consequences of impact by organic pollution in aquatic organisms [PDF]
, 1994 Organic contaminants are readily bioaccumulated by aquatic organisms. Exposure to and toxic effects of contaminants can be measured in terms of the biochemical responses of the organisms (i.e. molecular biomarkers).
Förlin, L. +2 more
core
Small, EarlyView.This study showcases a novel artificial intelligence (AI)‐driven design strategy for constructing highly specific and orally‐active fluorogenic substrates for imaging CYP3A4 in complex biological systems, while NFa emerged as a practical and reliable tool for sensing and imaging of CYP3A4 activity thus facilitating CYP3A4‐associated fundamental ...
Feng Zhang +13 more
wiley +1 more source
Modulation of Drug Metabolism by Food Restiction [PDF]
, 1985 The effects of the level and duration of feed restriction on the in vitro activities of hepatic drug metabolizing enzyme system were examined in male weanling Sprague Dawley rats fed ad libitum or feed restricted at 15%, 30% and 45% for a period of one ...
Su, Paul Kupen
core +1 more source
The Chemical Record, EarlyView.This review aims to comprehensively address recent degradation techniques (physical, chemical and biological) of halogenated waste polymers with a prime focus on thermal degradation techniques. Exploiting various metal oxides during co‐pyrolysis is deemed a viable solution for recycling halogenated polymeric waste.
Mohamed Shafi Kuttiyathil +2 more
wiley +1 more source