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The Cytochrome P450 Homepage [PDF]
Human Genomics, 2009 The Cytochrome P450 Homepage is a universal resource for nomenclature and sequence information on cytochrome P450 (CYP) genes. The site has been in continuous operation since February 1995.
Nelson David R
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Fungal cytochrome P450 database [PDF]
BMC Genomics, 2008 Background Cytochrome P450 enzymes play critical roles in fungal biology and ecology. To support studies on the roles and evolution of cytochrome P450 enzymes in fungi based on rapidly accumulating genome sequences from diverse fungal species, an ...
Ahn Kyohun +7 more
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Cytochrome P450 humanised mice [PDF]
Human Genomics, 2004 Humans are exposed to countless foreign compounds, typically referred to as xenobiotics. These can include clinically used drugs, environmental pollutants, food additives, pesticides, herbicides and even natural plant compounds.
Gonzalez Frank J
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Intronic polymorphisms of cytochromes P450 [PDF]
Human Genomics, 2010 The cytochrome P450 enzymes active in drug metabolism are highly polymorphic. Most allelic variants have been described for enzymes encoded by the cytochrome P450 family 2 (CYP2) gene family, which has 252 different alleles. The intronic polymorphisms in
Ingelman-Sundberg Magnus, Sim Sarah C
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Cytochrome P450 monooxygenase genes in the wild silkworm, Bombyx mandarina [PDF]
PeerJ, 2021 Wild (Bombyx mandarina) and domestic silkworms (B. mori) are good models for investigating insect domestication, as 5000 years of artificial breeding and selection have resulted in significant differences between B. mandarina and B. mori.
Linrong Wan +8 more
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Pharmaceutics, 2023 (1) Background: Human keratinocytes and murine skin express various cytochrome P450 enzymes. These include cytochrome P450 3A4, which may participate in the metabolism of cytochrome P450 3A4 substrate drugs.
Jiun-Wen Guo +4 more
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The Arabidopsis Book, 2011 There are 244 cytochrome P450 genes (and 28 pseudogenes) in the Arabidopsis genome. P450s thus form one of the largest gene families in plants. Contrary to what was initially thought, this family diversification results in very limited functional redundancy and seems to mirror the complexity of plant metabolism.
Bak, Søren +6 more
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The Arabidopsis Book, 2002 There are 272 cytochrome P450 genes (including 26 pseudogenes) in the Arabidopsis genome. P450s thus form one of the largest families of proteins in higher plants. This explosion of the P450 family is thought to have occurred via gene duplication and conversion, and to result from the need of sessile plants to adapt to a harsh environment and to ...
Danièle, Werck-Reichhart +2 more
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Communications Biology, 2021 Mukherjee, Nandekar and Wade investigate the structural arrangement of the complex between membrane-bound cytochrome P450 1A1 and NADPH-cytochrome P450 reductase.
Goutam Mukherjee +2 more
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Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis
Biomolecules, 2023 This study reports on the synthesis and evaluation of novel compounds replacing the nitrogen-containing heterocyclic ring on the chemical backbone structure of cytochrome P450 17α-hydroxylase/12,20-lyase (CYP17A1) inhibitors with a phenyl bearing a ...
Tomasz M. Wróbel +16 more
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