Results 31 to 40 of about 127,252 (263)

Liver cytochrome P450-hydroxylation system of tumor-bearing rats under the influence of ?-3 polyunsaturated fatty acids and vitamin D(3)

open access: yesThe Ukrainian Biochemical Journal, 2018
The study was performed to investigate the effects of the separate and combined action of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and vitamin D3 on the activity of the components of the oxygenase and reductase chains of the monooxygenase system ...
I. O. Shymanskyi   +3 more
doaj   +1 more source

Evolution favors protein mutational robustness in sufficiently large populations [PDF]

open access: yesBMC Biology 5:29 (2007), 2007
BACKGROUND: An important question is whether evolution favors properties such as mutational robustness or evolvability that do not directly benefit any individual, but can influence the course of future evolution. Functionally similar proteins can differ substantially in their robustness to mutations and capacity to evolve new functions, but it has ...
arxiv   +1 more source

Neutral genetic drift can aid functional protein evolution [PDF]

open access: yesBiology Direct 2:17 (2007), 2007
BACKGROUND: Many of the mutations accumulated by naturally evolving proteins are neutral in the sense that they do not significantly alter a protein's ability to perform its primary biological function. However, new protein functions evolve when selection begins to favor other, "promiscuous" functions that are incidental to a protein's biological role.
arxiv   +1 more source

The catalytic function of cytochrome P450 is entwined with its membrane-bound nature [version 1; referees: 4 approved]

open access: yesF1000Research, 2017
Cytochrome P450, a family of monooxygenase enzymes, is organized as a catalytic metabolon, which requires enzymatic partners as well as environmental factors that tune its complex dynamic.
Carlo Barnaba   +3 more
doaj   +1 more source

The Role of procollagen type 1 amino-terminal propertied (P1NP) Cytochrome P450 (CYPs) and Osteoprotegerin (OPG) as Potential Bone function markers in Prostate Cancer Bone Metastasis

open access: yesRomanian Journal of Laboratory Medicine, 2023
Background: Procollagen type I amino-terminal propeptide (PINP) is often present during osteoblast development and could be a biomarker of early bone development. Osteoprotegerin (OPG) may protect tumor cells from apoptosis.
Yousif Pshtiwan A.   +1 more
doaj   +1 more source

Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells

open access: yesScientific Reports, 2018
The COS-7 (CV-1 in Origin with SV40 genes) cells are known as non-steroidogenic cells because they are derived from kidney cells and the kidney is defined as a non-steroidogenic organ.
Mitsuki Nozaki   +9 more
doaj   +1 more source

HETEROLOGOUS EXPRESSION OF RECOMBINANT MOUSE CYTOCHROME P450 2E1 IN ESCHERICHIA COLI

open access: yesMìkrobìologìâ ì Bìotehnologìâ, 2012
Aim. The cloning of the mouse cytochrome P450 2E1 cDNA and obtaining of expression of cloned cDNA in E. coli. Methods. Polymerase chain reaction, cloning techniques, electrophoresis, Western blot. Results.
В. Н. Заец   +4 more
doaj   +1 more source

Remediation of bentazone contaminated water by Trametes versicolor: characterization, identification of transformation products, and implementation in a trickle-bed reactor under non-sterile conditions [PDF]

open access: yes, 2020
Bentazone, an herbicide widely applied in rice and cereal crops, is widespread in the aquatic environment. This study evaluated the capacity of Trametes versicolor to remove bentazone from water. The fungus was able to completely remove bentazone after three days at Erlenmeyer-scale incubation.
arxiv   +1 more source

Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin

open access: yesMolecules, 2010
We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)]
Svetlana Trivic   +4 more
doaj   +1 more source

The interplay between tubulins and P450 cytochromes during Plasmodium berghei invasion of Anopheles gambiae midgut. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: Plasmodium infection increases the oxidative stress inside the mosquito, leading to a significant alteration on transcription of Anopheles gambiae detoxification genes.
Rute C Félix, Henrique Silveira
doaj   +1 more source

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