Results 31 to 40 of about 308,115 (327)

Immunolocalization of steroidogenic enzymes in the vaginal mucous of Galea spixii during the estrous cycle. [PDF]

, 2017
BackgroundThe synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthesis, both of which must complex ...
Assis Neto, Antônio Chaves de, Conley, Alan James, de Oliveira, Moacir Franco, Dos Santos, Amilton Cesar, Oliveira, Gleidson Benevides, Viana, Diego Carvalho   +5 more
core   +1 more source

Liver cytochrome P450-hydroxylation system of tumor-bearing rats under the influence of ?-3 polyunsaturated fatty acids and vitamin D(3)

The Ukrainian Biochemical Journal, 2018
The study was performed to investigate the effects of the separate and combined action of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and vitamin D3 on the activity of the components of the oxygenase and reductase chains of the monooxygenase system ...
I. O. Shymanskyi, O. V. Ketsa, M. M. Marchenko, М. М. Veliky   +3 more
doaj   +1 more source

Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris

mBio, 2020
Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown what mechanisms
Jeffrey M. Rybak, José F. Muñoz, Katherine S. Barker, Josie E. Parker, Brooke D. Esquivel, Elizabeth L. Berkow, Shawn R. Lockhart, Lalitha Gade, Glen E. Palmer, Theodore C. White, Steve L. Kelly, Christina A. Cuomo, P. David Rogers   +12 more
doaj   +1 more source

Regulation of 3β-Hydroxysteroid Dehydrogenase/∆5-∆4 Isomerase: A Review [PDF]

, 2013
This review focuses on the expression and regulation of 3β-hydroxysteroi ddehydrogenase/Δ5-Δ4 isomerase (3β-HSD), with emphasis on the porcine version. 3β-HSD is often associated with steroidogenesis, but its function in the metabolism of both steroids ...
Abbaszade, Banner, Belanger, Beltowski, Benton, Berchtold, Bo Ekstrand, Brunius, Catalfo, Chapman, Chedrese, Chen, Chen, Cherradi, Clark, Coniglio, Conley, Conley, Conley, Cooke, Couet, Coulter, Cue, Davis, De Launoit, Doran, Doran, Dorgan, Dupont, Fink-Gremmels, Furster, Furster, Galarreta, Galia Zamaratskaia, Garrett, Garrett, Gingras, Gingras, Gromadzka-Ostrowska, Haider, Hassan, Havelock, Headon, Hierlihy, Hild-Petito, Hoog, Hu, Joernvall, Kallberg, Kaynard, Keeney, Keeney, Kershaw, Kiessling, Kostic, Kozlowska, Kumar, Labelle-Dumais, Labrie, LaVoie, Leers-Sucheta, Li, Liang, Lorence, Majdic, Martin, Martin Rasmussen, Mason, Mason, Matsunaga, Mcallister, Meadus, Mizrachi, Mode, Mullany, Nakajin, Nakamura, Naville, Nicolau-Solano, Papacleovoulou, Park, Payne, Payne, Payne, Pelletier, Penning, Picon, Rasmussen, Rasmussen, Rasmussen, Rasmussen, Saez, Samuels, Sasano, Sauer, Shapiro, Siiteri, Simard, Simard, Sirianni, Sordoillet, Stayrook, Sun, Suzuki, Takikawa, Takikawa, Tang, The, Tomankova, Tremblay, Val, Von Teichman, Walstra, Wang, Waxman, Waxman, Wong, Yuan, Zamaratskaia, Zamaratskaia, Zhao, Zinedine   +121 more
core   +2 more sources

Cytochrome P450 enzymes [PDF]

dmdi, 2012
No abstract available.
openaire   +2 more sources

Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame. [PDF]

, 2016
The endoplasmic reticulum (ER)-anchored hepatic cytochromes P450 (P450s) are enzymes that metabolize endo- and xenobiotics i.e. drugs, carcinogens, toxins, natural and chemical products.
Correia, Maria Almira, Kim, Sung-Mi, Liu, Yi, Nabavi, Noushin, Wang, YongQiang   +4 more
core   +1 more source

Cytochrome P450-Activated Prodrugs [PDF]

Future Medicinal Chemistry, 2013
A prodrug is a compound that has negligible, or lower, activity against a specified pharmacological target than one of its major metabolites. Prodrugs can be used to improve drug delivery or pharmacokinetics, to decrease toxicity, or to target the drug to specific cells or tissues.
openaire   +4 more sources

The catalytic function of cytochrome P450 is entwined with its membrane-bound nature [version 1; referees: 4 approved]

F1000Research, 2017
Cytochrome P450, a family of monooxygenase enzymes, is organized as a catalytic metabolon, which requires enzymatic partners as well as environmental factors that tune its complex dynamic.
Carlo Barnaba, Katherine Gentry, Nirupama Sumangala, Ayyalusamy Ramamoorthy   +3 more
doaj   +1 more source

Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. [PDF]

, 2008
The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification.
Finn, Robert, Henderson, Colin, Scott, Claire, Wolf, Roland   +3 more
core   +4 more sources

Strategies to inhibit steroid cytochrome P450 enzymes to benefit human health: development of steroid ligands for P450s 17A1, 19A1, and 8B1 to treat cancer and obesity. [PDF]

RSC Med Chem
Ho TM, Yoshimoto FK.
europepmc   +3 more sources