Results 81 to 90 of about 308,115 (327)
Zhongguo shiyan zhenduanxue, 2023 细胞色素P450氧化还原酶缺乏症(cytochrome P450 oxidoreductase deficiency, PORD)是先天性肾上腺皮质增生症(congenital adrenal hyperplasia, CAH)中罕见的类型，为细胞色素 P450 氧化还原酶(cytochrome P450 oxidoreductase, POR)基因纯合或杂合变异引起的常染色体隐性遗传病。
李卓 +4 more
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A simple and rapid method to measure cholesterol binding to P450s and other proteins
Journal of Lipid Research, 2005 Cholesterol plays an important role in cellular function and membrane compartmentalization and is involved in the interaction with more than a dozen of different proteins. Using three cholesterol-metabolizing cytochrome P450s (P450s 7A1, 46A1, and 11A1),
Natalia Mast, Irina A. Pikuleva
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In Vivo Evolution of Butane Oxidation by Terminal Alkane Hydroxylases AlkB and CYP153A6 [PDF]
, 2009 Enzymes of the AlkB and CYP153 families catalyze the first step in the catabolism of medium-chain-length alkanes, selective oxidation of the alkane to the 1-alkanol, and enable their host organisms to utilize alkanes as carbon sources.
Arnold, Frances H. +3 more
core +3 more sources
Advanced Science, EarlyView.Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu +10 more
wiley +1 more source
In-silico study of some natural compounds used as antifungal agents against Candida albicans
European Journal of Biological Research, 2020 Fungal diseases are very common these days, so there is a high need to design and develop new antifungal drugs that can counter these diseases. Candida albicans is one of the opportunistic pathogenic yeasts that can cause serious diseases such as ...
Ankita Srivastava, Neelabh -
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Membrane phospholipid augments cytochrome P4501a enzymatic activity by modulating structural conformation during detoxification of xenobiotics. [PDF]
PLoS ONE, 2013 Cytochrome P450 is a superfamily of membrane-bound hemoprotein that gets involved with the degradation of xenobiotics and internal metabolites. Accumulated body of evidence indicates that phospholipids play a crucial role in determining the enzymatic ...
Manik C Ghosh, Arun K Ray
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Forager bees (Apis mellifera) highly express immune and detoxification genes in tissues associated with nectar processing. [PDF]
, 2015 Pollinators, including honey bees, routinely encounter potentially harmful microorganisms and phytochemicals during foraging. However, the mechanisms by which honey bees manage these potential threats are poorly understood.
Johnson, Brian R +2 more
core +1 more source
Advanced Science, EarlyView.This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li +22 more
wiley +1 more source
Sains NaturalThe aim of this study was to evaluate the potential of brassicasterol found in mustard greens as a cytochrome P450 inhibitor using a computational approach.
Okta Suryani, Ade Irma Fahira
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Intronic polymorphisms of cytochromes P450
Human Genomics, 2010 The cytochrome P450 enzymes active in drug metabolism are highly polymorphic. Most allelic variants have been described for enzymes encoded by the cytochrome P450 family 2 (CYP2) gene family, which has 252 different alleles. The intronic polymorphisms in
Ingelman-Sundberg Magnus, Sim Sarah C
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