Results 61 to 70 of about 139,090 (361)

A mutant of Neurospora crassa deficient in cytochrome c heme lyase activity cannot import cytochrome c into mitochondria [PDF]

, 1988
The nuclear cyt-2-1 mutant of Neurospora crassa is characterized by a gross deficiency of cytochrome c (Bertrand, H., and Collins, R. A. (1978) Mol. Gen. Genet. 166, 1-13).
Drygas, Mariola E., Kwong, Patrick L., Nargang, Frank E., Neupert, Walter, Nicholson, Donald W.   +4 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Expression and Clinical Significance of Cytochrome 1B1 in Bone Sarcomas

Pharmaceuticals
Background/Objectives: Cytochrome 1B1 (CYP1B1) is overexpressed in several cancers, contributing to carcinogenesis, cancer progression, and chemoresistance. Despite its known oncogenic role, its expression in bone sarcomas remains unknown.
Belal Al-zu’bi, Fatemah OFO Alshammari, Randa AlQaisi, Jaber H. Jaradat, Marwan Herzallah, Mohannad Ja’Awin, Anas O. Satari, Yousef M. Al-saraireh, Mohammad Salem Hareedy   +8 more
doaj   +1 more source

QNA-Based Prediction of Sites of Metabolism

Molecules, 2017
Metabolism of xenobiotics (Greek xenos: exogenous substances) plays an essential role in the prediction of biological activity and testing for the subsequent research and development of new drug candidates.
Olga Tarasova, Anastassia Rudik, Alexander Dmitriev, Alexey Lagunin, Dmitry Filimonov, Vladimir Poroikov   +5 more
doaj   +1 more source

Divergent Cytochrome c Maturation System in Kinetoplastid Protists

mBio, 2021
Cytochromes ...
Asma Belbelazi, Rachel Neish, Martin Carr, Jeremy C. Mottram, Michael L. Ginger   +4 more
doaj   +1 more source

Pseudomonas Cytochrome c551 at 2.0 angstrom Resolution: Enlargement of the Cytochrome c Family [PDF]

, 1978
The structure of respiratory cytochrome c551 of Pseudomonas aeruginosa, with 82 amino acids, has been solved by x-ray analysis and refined to a crystallographic R factor of 16.2%.
Almassy, Robert J., Dickerson, Richard E.   +1 more
core  

Active Carboxylic Acid-Terminated Alkanethiol Self-Assembled Monolayers on Gold Bead Electrodes for Immobilization of Cytochromes c [PDF]

, 2002
It is extremely difficult to immobilize cytochrome c (cyt c) on carboxylic acid-terminated alkanethiol self-assembled monolayers (HOOC-SAM) on gold bead electrodes prepared in a hydrogen flame.
Gray, Harry B., Hill, Michael G., Margoliash, Emanuel, Niki, Katsumi, Ohno, Hiroyuki, Tanimura, Ryutaro   +5 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Deciphering Molecular Factors That Affect Electron Transfer at the Cell Surface of Electroactive Bacteria: The Case of OmcA from Shewanella oneidensis MR-1

Microorganisms, 2022
Multiheme cytochromes play a central role in extracellular electron transfer, a process that allows microorganisms to sustain their metabolism with external electron acceptors or donors.
Ricardo O. Louro, Giovanni Rusconi, Bruno M. Fonseca, Catarina M. Paquete   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source