Results 21 to 30 of about 191,272 (307)

Excellent outcomes of 2G-TKI therapy after imatinib failure in chronic phase CML patients [PDF]

, 2018
open25noSecond-generation tyrosine kinase inhibitors (2G-TKIs) dasatinib and nilotinib produced historical rates of about 50% complete cytogenetic response (CCyR) and about 40% major molecular response (MMR) in chronic myeloid leukaemia (CML) patients ...

core   +1 more source

Molecular cytogenetic mapping of Cucumis sativus and C. melo using highly repetitive DNA sequences [PDF]

, 2010
Chromosomes often serve as one of the most important molecular aspects of studying the evolution of species. Indeed, most of the crucial mutations that led to differentiation of species during the evolution have occurred at the chromosomal level ...
Bang, J.W., Choi, D., Hur, Y., Jong, J.H.S.G.M., de, Koo, D.H., Nam, Y.W.   +5 more
core   +3 more sources

16p11.2 microdeletion syndrome: a case report

Journal of Medical Case Reports, 2018
Background The recurrent ∼ 600 kb 16p11.2 microdeletion is among the most commonly known genetic etiologies of autism spectrum disorder, overweightness, and related neurodevelopmental disorders.
D. Dell’Edera, C. Dilucca, A. Allegretti, F. Simone, M. G. Lupo, C. Liccese, R. Davanzo   +6 more
doaj   +1 more source

Array comparative genomic hybridization and flow cytometry analysis of spontaneous abortions and mors in utero samples [PDF]

, 2009
Background: It is estimated that 10-15% of all clinically recognised pregnancies result in a spontaneous abortion or miscarriage. Previous studies have indicated that in up to 50% of first trimester miscarriages, chromosomal abnormalities can be ...
Björn Menten, Katrien Swerts, Barbara Delle Chiaie, Sandra Janssens, Karen Buysse, Jan Philippé, Frank Speleman, T Hassold, V Jobanputra, M Goddijn, KA Bell, B Lomax, J Menasha, DL Bruno, D Diego-Alvarez, D Diego-Alvarez, DN Azmanov, M Daniely, B Fritz, Y Hu, A Kallioniemi, AC Tabet, J Berezowsky, B Menten, D Pinkel, S Solinas-Toldo, B Menten, K Benirschke, M Benkhalifa, M Nagaishi, AJ Schaeffer   +30 more
core   +1 more source

MOLECULAR CYTOGENETIC CHARACTERIZATION OF DER(7)T(1;7) IN MYELODYSPLASTIC SYNDROME: CLINICAL IMPLICATIONS

Hematology, Transfusion and Cell Therapy
Introduction: Myelodysplastic syndrome (MDS) represents a heterogeneous group of hematologic malignancies characterized by ineffective hematopoiesis, resulting in cytopenias and a high risk of progression to acute myeloid leukemia (AML). Approximately 50%
GF Lima, BF Silva, IC Gonçalves, L Otero, MM Rocha, VL Lovatel, TS Fernandez   +6 more
doaj   +1 more source

Chromosomal aberrations in pregnancy and fetal loss: Insight on the effect of consanguinity, review of 1625 cases

Molecular Genetics & Genomic Medicine, 2019
Background Pregnancy loss affects 10%–15% of pregnancies and is caused by several factors, maternal and fetal. Most common cause is chromosomal aneuploidy and has traditionally been detected by karyotyping product of conception and/or fetal tissue.
Kimia Najafi, Soheila Gholami, Azadeh Moshtagh, Masood Bazrgar, Neda Sadatian, Golemaryam Abbasi, Parvin Rostami, Soheila Khalili, Mojgan Babanejad, Bahareh Nourmohammadi, Negin Faramarzi Garous, Hossein Najmabadi, Roxana Kariminejad   +12 more
doaj   +1 more source

Painting of human chromosomes with probes generated from hybrid cell lines by PCR with Alu and L1 primers [PDF]

, 1990
Specific amplification of human sequences of up to several kb length has recently been accomplished in man-hamster and man-mouse somatic hybrid cell DNA by IRS-PCR (interspersed repetitive sequence — polymerase chain reaction).
Cremer, Thomas, Lengauer, Christoph, Riethman, Harold C.   +2 more
core   +1 more source

ASSOCIATION BETWEEN EZH2 EXPRESSION PATTERN WITH KARYOTYPE AND EVOLUTION FROM MYELODYSPLASTIC NEOPLASM TO ACUTE MYELOID LEUKEMIA

Hematology, Transfusion and Cell Therapy
Introduction: Myelodysplastic Neoplasm (MDS) is a heterogeneous group of clonal hematopoietic stem cell diseases. MDS is characterized by the presence of bone marrow (BM) dysplasias, peripheral blood cytopenias and is frequently associated with ...
IC Gonçalves, GF Lima, BF Silva, VL Lovatel, TS Fernandez   +4 more
doaj   +1 more source

Genetic and epigenetic factors: Role in male infertility

Indian Journal of Urology, 2011
Genetic factors contribute upto 15%-30% cases of male infertility. Formation of spermatozoa occurs in a sequential manner with mitotic, meiotic, and postmeiotic differentiation phases each of which is controlled by an intricate genetic program.
M B Shamsi, K Kumar, R Dada
doaj   +1 more source

A karyomorphological comparison of seven species of Achillea L. from Kurdistan of Iran

Caryologia, 2023
We conducted the present study on seven important medicinal species of Achillea (in a total of 28 populations) in their natural habitats. The results indicated that the populations had a base number (x= 9) and the diploid, tetraploid, and hexaploidy ...
Fatemeh Nezhadi, Farzad Fayaz, Ezzat Karami, Hooshmand Safari, Abdol Rahman Rahimi   +4 more
doaj   +1 more source